3.4.22.69: SARS coronavirus main proteinase

0.0071

(2E)-1-[3-(2-hydroperoxy-3-methylbut-3-en-1-yl)-2-hydroxy-4-methoxyphenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.005

(2E)-N-[2-[4-(dimethylamino)butyl]phenyl]-3-phenylprop-2-enamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.44

(2S)-2-(8[(1R,3S,4aR,8aS)-1-[[butyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C, mutant enzyme R188I

0.78

(2S)-2-([(1R,3R,4aR,8aS)-1-8[butyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C, mutant enzyme R188I

0.26

(2S)-2-([[(1S,3R,4aR,8aS)-1-[[butyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C, mutant enzyme R188I

0.095

(2S)-2-([[(1S,3S,4aR,8aS)-1[butyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methylamino)-3-(1H-imidazol-4-yl)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C, mutant enzyme R188I

0.42

(2S)-2-([[(1S,4aR,8aS)-1-[[benzyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C, mutant enzyme R188I

0.1

(2S)-2-([[(1S,4aR,8aS)-1-[[butyl(methyl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C, mutant enzyme R188I

0.175

(2S)-2-([[(3R,4aS,8aR)-2-(4-bromobenzoyl)decahydroisoquinolin-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C

0.057

(2S)-2-([[(3R,4aS,8aR)-2-(4-fluorophenyl)decahydroisoquinolin-3-yl]methyl]amino)-3-(1H-imidazol-5-yl)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.7, 37°C

0.24

(2S)-2-([[(3R,4aS,8aR)-2-([1,1'-biphenyl]-4-carbonyl)decahydroisoquinolin-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C

0.041

(2S)-2-([[(3S,4aR,8aS)-2-(4-bromobenzoyl)decahydroisoquinolin-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C

0.063

(2S)-2-([[(3S,4aR,8aS)-2-(4-bromobenzoyl)decahydroisoquinolin-3-yl]methyl]amino)-3-(1H-imidazol-5-yl)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.7, 37°C

0.057

(2S)-2-([[(3S,4aR,8aS)-2-(4-fluorobenzoyl)decahydroisoquinolin-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C

0.108

(2S)-2-([[(3S,4aR,8aS)-2-(biphenyl-4-ylcarbonyl)decahydroisoquinolin-3-yl]methyl]amino)-3-(1H-imidazol-5-yl)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.7, 37°C

0.135

(2S)-2-([[(3S,4aR,8aS)-2-([1,1'-biphenyl]-2-carbonyl)decahydroisoquinolin-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C

0.135

(2S)-2-([[(3S,4aR,8aS)-2-([1,1'-biphenyl]-3-carbonyl)decahydroisoquinolin-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C

0.108

(2S)-2-([[(3S,4aR,8aS)-2-([1,1'-biphenyl]-4-carbonyl)decahydroisoquinolin-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C

0.068

(2S)-2-([[(3S,4aR,8aS)-2-benzoyldecahydroisoquinolin-3-yl]methyl]amino)-3-(1H-imidazol-4-yl)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C

0.42

(2S)-3-(1H-imidazol-4-yl)-2-([[(1S,4aR,8aS)-1-[[methyl(prop-2-en-1-yl)amino]methyl]octahydro-1H-2-benzopyran-3-yl]methyl]amino)propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C, mutant enzyme R188I

0.0362

(4E)-1,7-bis(3,4-dihydroxyphenyl)hept-4-en-3-one

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.00066

(5S,8S,11S,E)-methyl 8-isobutyl-5-isopropyl-3,6,9-trioxo-11-(((S)-2-oxopyrrolidin-3-yl)methyl)-1-phenyl-2-oxa-4,7,10-triazatetradec-12-en-14-oate

Severe acute respiratory syndrome-related coronavirus

enzyme mutant R188I, pH and temperature not specified in the publication

0.065

(R)-N-(E)-3',4',5'-trimethoxy-3-phenylprop-2-enoicserine(benzoyl)cyclohexylamide

Severe acute respiratory syndrome-related coronavirus

pH 4.0, temperature not specified in the publication

752992

0.03

(R)-N-cinnamoyl serine(benzoyl)cyclohexylamide

Severe acute respiratory syndrome-related coronavirus

pH 4.0, temperature not specified in the publication

752992

0.0006

(S)-2-((2S,3R)-2-((S)-2-acetamido-3-methylbutanamido)-3-(benzyloxy)butanamido)-4-methyl-N-((S)-4-(5-nitro-1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)pentanamide

Severe acute respiratory syndrome-related coronavirus

0.215

(S)-2-[([(3R,4aS,8aR)-2-[3-(phenylamino)-propan-1-carbonyl]decahydroisoquinolin-3-yl]methyl)amino]-3-(1H-imidazol-4-yl)-propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C

753022

0.276

(S)-2-[([(3S,4aR,8aS)-2-[3-(phenylamino)-propan-1-carbonyl]decahydroisoquinolin-3-yl]methyl)amino]-3-(1H-imidazol-4-yl)-propanal

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C

753022

0.000065

(S)-N-((S)-1-(((S)-1-(1H-imidazol-4-yl)-3-oxopropan-2-yl)amino)-3-cyclohexyl-1-oxopropan-2-yl)-2-((S)-2-((S)-2-acetamido-3-hydroxypropanamido)propanamido)-3-methylbutanamide

Severe acute respiratory syndrome-related coronavirus

enzyme mutant R188I, pH and temperature not specified in the publication

0.014

(S)-N-((S)-1-(benzo[d]thiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-(2-((2-methoxyphenyl)amino)acetamido)-4-methylpentanamide

Severe acute respiratory syndrome-related coronavirus

enzyme mutant R188I, pH and temperature not specified in the publication

0.01

(S)-N-((S)-1-(benzo[d]thiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-(2-((3-methoxyphenyl)amino)acetamido)-4-methylpentanamide

Severe acute respiratory syndrome-related coronavirus

enzyme mutant R188I, pH and temperature not specified in the publication

0.043

(S)-N-((S)-1-(benzo[d]thiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-(2-(4-methoxyphenyl)acetamido)-4-methylpentanamide

Severe acute respiratory syndrome-related coronavirus

enzyme mutant R188I, pH and temperature not specified in the publication

0.0017

(S)-N-((S)-1-(benzo[d]thiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-4-methyl-2-((S)-3-methyl-2-(2-phenoxyacetamido)butanamido)pentanamide

Severe acute respiratory syndrome-related coronavirus

enzyme mutant R188I, pH and temperature not specified in the publication

0.024

(S)-N-((S)-1-(benzo[d]thiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-4-methyl-2-(2-phenoxyacetamido)pentanamide

Severe acute respiratory syndrome-related coronavirus

enzyme mutant R188I, pH and temperature not specified in the publication

0.025

1,1'-sulfonylbis(4-nitrobenzene)

Severe acute respiratory syndrome-related coronavirus

0.0037 - 0.0069

1,2,3,4,6-pentagalloylglucose

0.043

1,6-di(propan-2-yl)-N-(4-[[4-(prop-2-en-1-yl)-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl]methyl]-1,3-thiazol-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

Severe acute respiratory syndrome-related coronavirus

mutant R188I, pH not specified in the publication, temperature not specified in the publication

752992

0.00095

1-(1-benzothiophen-2-ylmethyl)-5-iodo-1H-indole-2,3-dione

Severe acute respiratory syndrome-related coronavirus

0.00037

1-(2-naphthylmethyl)-2,3-dioxoindoline-5-carboxamide

Severe acute respiratory syndrome-related coronavirus

0.00037

1-(2-naphthylmethyl)isatin-5-carboxamide

Severe acute respiratory syndrome-related coronavirus

709130

0.0081

1-butyl-N-[4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzyl]-1H-benzimidazol-2-amine

Severe acute respiratory syndrome-related coronavirus

0.0002

1-[(1H-indol-5-ylcarbonyl)oxy]-1H-benzotriazole

Severe acute respiratory syndrome-related coronavirus

0.012

1-[(4-chlorophenyl)sulfonyl]-2-nitro-4-(trifluoromethyl)benzene

Severe acute respiratory syndrome-related coronavirus

0.06279

1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-4-[2-methyl-4-(2-methylpropoxy)benzoyl]-1,5-dihydro-2H-pyrrol-2-one

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.018

2',5'-dimethyl-3-(methylthio)-4'-nitro-5-(2-thienyl)-2'H-1,3'-bipyrazole-4-carbonitrile

Severe acute respiratory syndrome-related coronavirus

0.0003

2,4-dichloro-5-methylphenyl 2,6-dinitro-4-(trifluoromethyl)phenyl sulfone

Severe acute respiratory syndrome-related coronavirus

0.000051

2-(1H-benzotriazol-1-yl)-N-(biphenyl-4-yl)-N-(thiophen-3-ylmethyl)acetamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0253

2-(1H-benzotriazol-1-yl)-N-[2-(tert-butylamino)-2-oxo-1-(thiophen-3-yl)ethyl]-N-[4-[(methylsulfonyl)amino]phenyl]acetamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.063 - 0.148

2-(1H-benzotriazol-1-yl)-N-[4-(1H-imidazol-4-yl)phenyl]-N-[(thiophen-3-yl)methyl]acetamide

0.106 - 0.109

2-(1H-benzotriazol-1-yl)-N-[4-(1H-pyrazol-4-yl)phenyl]-N-[(thiophen-3-yl)methyl]acetamide

0.0015

2-(1H-benzotriazol-1-yl)-N-[4-(benzylamino)phenyl]-N-(thiophen-3-ylmethyl)acetamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0021

2-(1H-benzotriazol-1-yl)-N-[4-(methylamino)phenyl]-N-(thiophen-3-ylmethyl)acetamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.00097

2-(1H-benzotriazol-1-yl)-N-[4-(pyridin-3-yl)phenyl]-N-(thiophen-3-ylmethyl)acetamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.93 - 0.95

2-(1H-benzotriazol-1-yl)-N-[4-(pyridin-3-yl)phenyl]-N-[(thiophen-3-yl)methyl]acetamide

0.002

2-(1H-benzotriazol-1-yl)-N-[4-(pyridin-4-yl)phenyl]-N-(thiophen-3-ylmethyl)acetamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.657 - 0.746

2-(1H-benzo[d][1,2,3]triazol-1-yl)-N-(3-chlorobenzyl)-N-[4-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]acetamide

0.032

2-(3',4'-dihydroxyphenyl)-5,7-dihydroxy-3-beta-D-arabinosyl-4H-chromen-4-one

Severe acute respiratory syndrome-related coronavirus

0.043

2-(3',4'-dihydroxyphenyl)-5,7-dihydroxy-3-beta-D-galactosyl-4H-chromen-4-one

Severe acute respiratory syndrome-related coronavirus

0.049

2-(3',4'-dihydroxyphenyl)-5,7-dihydroxy-3-beta-D-glucosyl-4H-chromen-4-one

Severe acute respiratory syndrome-related coronavirus

0.024

2-(3',4'-dihydroxyphenyl)-5,7-dihydroxy-3-beta-L-fucosyl-4H-chromen-4-one

Severe acute respiratory syndrome-related coronavirus

0.061

2-(3',4'-dihydroxyphenyl)-5-hydroxy-3,7-di(beta-D-galactosyl)-4H-chromen-4-one

Severe acute respiratory syndrome-related coronavirus

0.04

2-(4,5-dihydro-1,3-thiazol-2-yl)-1-(1,3-thiazol-2-yl)ethanone

Severe acute respiratory syndrome-related coronavirus

0.0043

2-(4-aminophenyl)-6-methyl-1H-benzimidazole-7-sulfonic acid

Severe acute respiratory syndrome-related coronavirus

0.075

2-(5-bromopyridin-3-yl)-1-(2-(4-chlorophenyl)oxazol-5-yl)ethanone

Severe acute respiratory syndrome-related coronavirus

0.057

2-(5-bromopyridin-3-yl)-1-(5-(4-chlorophenyl)furan-2-yl)-2,2-difluoroethanone

Severe acute respiratory syndrome-related coronavirus

0.028

2-(5-bromopyridin-3-yl)-1-(5-(4-chlorophenyl)furan-2-yl)-2-fluoroethanone

Severe acute respiratory syndrome-related coronavirus

0.013

2-(5-bromopyridin-3-yl)-1-(5-(4-chlorophenyl)furan-2-yl)ethanone

Severe acute respiratory syndrome-related coronavirus

0.013

2-(5-bromopyridin-3-yl)-1-[5-(4-chlorophenyl)furan-2-yl]ethanone

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.197 - 0.208

2-(benzotriazol-1-yl)-N-[(3-chlorophenyl)methyl]-N-[2-methoxy-4-(1H-pyrazol-4-yl)phenyl]acetamide

0.206 - 0.328

2-(benzotriazol-1-yl)-N-[(3-chlorophenyl)methyl]-N-[3-methoxy-4-(1H-pyrazol-4-yl)phenyl]acetamide

0.25 - 0.39

2-(benzotriazol-1-yl)-N-[(3-chlorophenyl)methyl]-N-[4-(3-pyridyl)phenyl]acetamide

0.171 - 0.214

2-(benzotriazol-1-yl)-N-[(3-chlorophenyl)methyl]-N-[5-(1H-pyrazol-4-yl)-2-pyridyl]acetamide

0.333 - 0.336

2-(benzotriazol-1-yl)-N-[(3-chlorophenyl)methyl]-N-[6-(1H-pyrazol-4-yl)-3-pyridyl]acetamide

0.00017

2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-N-(3-chlorophenethyl)-2-(pyridin-3-yl)acetamide

Severe acute respiratory syndrome coronavirus 2

pH 7.3, 25°C

0.00024

2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-N-(3-methoxyphenethyl)-2-(pyridin-3-yl)acetamide

Severe acute respiratory syndrome coronavirus 2

pH 7.3, 25°C

0.00052

2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-N-(3-phenylpropyl)-2-(pyridin-3-yl)acetamide

Severe acute respiratory syndrome coronavirus 2

pH 7.3, 25°C

0.00028

2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-N-(4-methoxyphenethyl)-2-(pyridin-3-yl)acetamide

Severe acute respiratory syndrome coronavirus 2

pH 7.3, 25°C

0.00042

2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-N-cyclohexyl-2-(pyridin-3-yl)acetamide

Severe acute respiratory syndrome coronavirus 2

pH 7.3, 25°C

0.0098

2-acetyl-3-(3-iodophenyl)-7-methoxy-3,3a,4,5-tetrahydro-2H-benzo[g]indazole

Severe acute respiratory syndrome-related coronavirus

0.007

2-benzyl-2H-isoindole-4,7-dione

Severe acute respiratory syndrome-related coronavirus

0.0103

2-methylpropyl [4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl]carbamate

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0025

2-phenylethyl 2-methyl-4-(2-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

Severe acute respiratory syndrome-related coronavirus

0.016

2-[(2-acetylphenyl)sulfonyl]benzoic acid

Severe acute respiratory syndrome-related coronavirus

0.0182

2-[(2-cyclohexylquinazolin-4-yl)sulfanyl]-N-(furan-2-ylmethyl)acetamide

Severe acute respiratory syndrome-related coronavirus

691218

0.000516

2-[(4-chlorophenyl)disulfanyl]-1,3,4-oxadiazole

Severe acute respiratory syndrome-related coronavirus

pH 7.3, 37°C

753488

0.000684

2-[(4-chlorophenyl)disulfanyl]pyrimidine

Severe acute respiratory syndrome-related coronavirus

pH 7.3, 37°C

753488

0.015

2-[(4-chlorophenyl)sulfonyl]-5-nitropyridine 1-oxide

Severe acute respiratory syndrome-related coronavirus

0.0106

2-[(4-nitrobenzyl)sulfanyl]-4-(3-nitrophenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

Severe acute respiratory syndrome-related coronavirus

0.0353

2-[(4-nitrobenzyl)sulfanyl]-6-oxo-4-phenyl-1,6-dihydropyrimidine-5-carbonitrile

Severe acute respiratory syndrome-related coronavirus

0.0361

2-[3-[(2Z)-3-(2H-1,3-benzodioxol-5-yl)prop-2-enoyl]-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-1-yl]acetamide

Severe acute respiratory syndrome coronavirus 2

pH 7.3, temperature not specified in the publication

764635

0.0085

2-[4-(chloroacetyl)-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]-N-(3-chlorophenyl)acetamide

Severe acute respiratory syndrome coronavirus 2

pH 7.3, temperature not specified in the publication

764635

0.03317

3,4',5,7,8-pentahydroxyflavone

Severe acute respiratory syndrome-related coronavirus

pH 6.5, 37°C

754293

0.007

3,4-dichloro-5-[2-(5-chloro-3-methyl-1-benzothien-2-yl)-2-oxoethyl]furan-2(5H)-one

Severe acute respiratory syndrome-related coronavirus

0.0025

3,4-dichloro-5-[2-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-oxoethyl]furan-2(5H)-one

Severe acute respiratory syndrome-related coronavirus

679408

0.0025

3-(4-bromophenyl)-5-(4-chlorophenyl)-1-(3,4-dichlorophenyl)-4-(1H-imidazol-1-yl)-4,5-dihydro-1H-pyrazole

Severe acute respiratory syndrome-related coronavirus

0.05

3-(N-L-gamma-Glu-L-Ala)-1,1,1-trifluoropropan-2-one

Severe acute respiratory syndrome-related coronavirus

0.0172

3-benzyl-1-[(6,7-dimethyl-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)methyl]-1-[2-(2-methylphenyl)ethyl]urea

Severe acute respiratory syndrome-related coronavirus

enzyme mutant R188I, pH and temperature not specified in the publication

0.0172

3-benzyl-1-[(6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-1-[2-(2-methylphenyl)ethyl]urea

Severe acute respiratory syndrome-related coronavirus

691218

0.016

3-[(2-furylmethyl)amino]-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-2-benzothiophene-1-carbonitrile

Severe acute respiratory syndrome-related coronavirus

0.01

3-[1-(4-benzyloxyphenyl)-1H-tetrazol-5-ylthio]-4-hydroxyquinolin-2-(1H)one

Severe acute respiratory syndrome-related coronavirus

in 10 mM HEPES at pH 7.5, temperature not specified in the publication

0.002

3-[1-(4-benzyloxyphenyl)-1H-tetrazol-5-ylthio]-4-methoxyquinolin-2-(1H)one

Severe acute respiratory syndrome-related coronavirus

in 10 mM HEPES at pH 7.5, temperature not specified in the publication

0.0125

3-[1-(4-ethoxyphenyl)-1H-tetrazol-5-ylthio]-4-hydroxyquinolin-2-(1H)one

Severe acute respiratory syndrome-related coronavirus

in 10 mM HEPES at pH 7.5, temperature not specified in the publication

0.015

3-[N-(N-benzyloxycarbonyl-L-Leu)]-4-phenyl-1,1,1-trifluorobutan-2-one

Severe acute respiratory syndrome-related coronavirus

0.02

3-[N-(N-benzyloxycarbonyl-L-Phe)]-4-phenyl-1,1,1-trifluorobutan-2-one

Severe acute respiratory syndrome-related coronavirus

0.04

3-[N-(N-tert-butoxycarbonyl)-L-Leu]-1,1,1-trifluorobutan-2-one

Severe acute respiratory syndrome-related coronavirus

0.01

3-[N-[N-benzyloxycarbonyl-L-Ala-L-Val-L-Leu]]-4-phenyl-1,1,1-trifluorobutan-2-one

Severe acute respiratory syndrome-related coronavirus

0.05

3-[N-[N-decanoyl-L-Leu]]-4-phenyl-1,1,1-trifluorobutan-2-one

Severe acute respiratory syndrome-related coronavirus

0.04

3-[N-[N-tert-butoxycarbonyl-L-gamma-Glu(OtBu)-L-Ala]]-1,1,1-trifluoropropan-2-one

Severe acute respiratory syndrome-related coronavirus

0.013

4,6-dimethyl-2-[(4-methylphenyl)sulfonyl]-5-nitronicotinonitrile

Severe acute respiratory syndrome-related coronavirus

0.013

4,6-dimethyl-5-nitro-2-(phenylsulfonyl)nicotinonitrile

Severe acute respiratory syndrome-related coronavirus

0.0006

4-((S)-2-((2S,3S)-2-((S)-2-acetamido-3-methylbutanamido)-3-(benzyloxy)butanamido)-4-methylpentanamido)-N,N-dimethyl-6-(5-nitro-1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl)-5-oxohexanamide

Severe acute respiratory syndrome-related coronavirus

enzyme mutant R188I, pH and temperature not specified in the publication

0.0061

4-(4-chlorophenyl)-2-[(4-nitrobenzyl)sulfanyl]-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

0.0169

4-(4-chlorophenyl)-6-oxo-2-[(2-phenylethyl)sulfanyl]-1,6-dihydropyrimidine-5-carbonitrile

Severe acute respiratory syndrome-related coronavirus

0.0263

4-(4-methoxyphenyl)-2-[(4-nitrobenzyl)sulfanyl]-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

Severe acute respiratory syndrome-related coronavirus

0.0203

4-(4-methoxyphenyl)-6-oxo-2-[(2-phenylethyl)sulfanyl]-1,6-dihydropyrimidine-5-carbonitrile

Severe acute respiratory syndrome-related coronavirus

0.018

4-(5-chloro-2-thienyl)-2-[(2-thienylsulfonyl)methyl]-1,3-thiazole

Severe acute respiratory syndrome-related coronavirus

0.05835

4-([[4-cyclohexyl-5-(naphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]methyl)-1,3-thiazol-2-amine

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0125

4-benzyloxy-3-[1-(4-benzyloxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one

Severe acute respiratory syndrome-related coronavirus

in 10 mM HEPES at pH 7.5, temperature not specified in the publication

0.0125

4-benzyloxy-3-[1-(4-ethoxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one

Severe acute respiratory syndrome-related coronavirus

in 10 mM HEPES at pH 7.5, temperature not specified in the publication

0.0125

4-benzyloxy-3-[1-(4-methoxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one

Severe acute respiratory syndrome-related coronavirus

in 10 mM HEPES at pH 7.5, temperature not specified in the publication

0.0125

4-hydroxy-3-[1-(4-hydroxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one

Severe acute respiratory syndrome-related coronavirus

in 10 mM HEPES at pH 7.5, temperature not specified in the publication

0.0125

4-hydroxy-3-[1-(4-methoxyphenyl)-1H-tetrazol-5-ylthio]quinolin-2-(1H)one

Severe acute respiratory syndrome-related coronavirus

in 10 mM HEPES at pH 7.5, temperature not specified in the publication

0.0072

4-methoxy-6-[([1,3]thiazolo[5,4-b]pyridin-2-ylsulfinyl)methyl]-2H-pyran-2-one

Severe acute respiratory syndrome-related coronavirus

0.1014

4-[(2,4-dimethyl-1,3-thiazol-5-yl)carbonyl]-3-hydroxy-1-[3-(morpholin-4-yl)propyl]-5-(3-nitrophenyl)-1,5-dihydro-2H-pyrrol-2-one

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.016

4-[(3,5-dibromo-4-hydroxyphenyl)sulfonyl]benzoic acid

Severe acute respiratory syndrome-related coronavirus

0.0033

4-[(E)-[(2-methoxyphenyl)imino]methyl]-2-phenyl-1,3-oxazol-5-yl acetate

Severe acute respiratory syndrome-related coronavirus

0.0068

4-[(Z)-[1-(4-fluorophenyl)-5-oxo-3-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene]methyl]benzoic acid

Severe acute respiratory syndrome-related coronavirus

enzyme mutant R188I, pH and temperature not specified in the publication

0.0125

5,7-dichloro-4-hydroxy-3-[1-(4-methoxy-phenyl)-1H-tetrazol-5-ylsulfanyl]-1H-quinolin-2-one

Severe acute respiratory syndrome-related coronavirus

in 10 mM HEPES at pH 7.5, temperature not specified in the publication

0.01 - 0.0106

5,7-dichloro-4-hydroxy-3-[[1-(4-hydroxyphenyl)-1H-tetrazol-5-yl]sulfanyl]quinolin-2(1H)-one

0.03778

5,7-dihydroxy 4',6-dimethoxyflavone 7-rutinoside

Severe acute respiratory syndrome-related coronavirus

pH 6.5, 37°C

754293

0.005

5-(1,3-dimethyl-1H-pyrazol-5-yl)-N-(3-methyl-4-nitroisoxazol-5-yl)thiophene-2-carboxamide

Severe acute respiratory syndrome-related coronavirus

0.00104

5-(4-methylpiperidine-1-sulfonyl)-1-phenyl-1H-indole-2,3-dione

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.00118

5-(4-methylpiperidine-1-sulfonyl)-1H-indole-2,3-dione

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0191

5-bromo-2-[(2Z)-2-[5-cyano-1-(3-hydroxypropyl)-4-methyl-2,6-dioxo-1,6-dihydropyridin-3(2H)-ylidene]hydrazinyl]benzoic acid

Severe acute respiratory syndrome coronavirus 2

pH 7.3, temperature not specified in the publication

764635

0.0005

5-bromopyridin-3-yl thiophene-2-carboxylate

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.00014

5-chloropyridin-3-yl (3S)-2-acetyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Severe acute respiratory syndrome-related coronavirus

0.00108

5-chloropyridin-3-yl 1-acetyl-1H-indole-4-carboxylate

Severe acute respiratory syndrome-related coronavirus

0.0004

5-chloropyridin-3-yl 1-acetyl-1H-indole-5-carboxylate

Severe acute respiratory syndrome-related coronavirus

0.000124

5-chloropyridin-3-yl 1-naphthoate

Severe acute respiratory syndrome-related coronavirus

0.000089

5-chloropyridin-3-yl 1-[(3-nitrophenyl)sulfonyl]-1H-indole-5-carboxylate

Severe acute respiratory syndrome-related coronavirus

0.00037

5-chloropyridin-3-yl 1-[(4-methylphenyl)sulfonyl]-1H-indole-5-carboxylate

Severe acute respiratory syndrome-related coronavirus

0.00003

5-chloropyridin-3-yl 1H-indole-4-carboxylate

0.00031

5-chloropyridin-3-yl 1H-indole-5-carboxylate

Severe acute respiratory syndrome-related coronavirus

0.00023

5-chloropyridin-3-yl 1H-indole-6-carboxylate

Severe acute respiratory syndrome-related coronavirus

0.00008

5-chloropyridin-3-yl 1H-indole-7-carboxylate

Severe acute respiratory syndrome-related coronavirus

0.000333

5-chloropyridin-3-yl 2-nitrobenzoate

Severe acute respiratory syndrome-related coronavirus

0.000108

5-chloropyridin-3-yl 2-oxo-2H-chromene-3-carboxylate

Severe acute respiratory syndrome-related coronavirus

0.000648

5-chloropyridin-3-yl 3-nitrobenzoate

Severe acute respiratory syndrome-related coronavirus

0.000434

5-chloropyridin-3-yl 4-chlorobenzoate

Severe acute respiratory syndrome-related coronavirus

0.000208

5-chloropyridin-3-yl 5-(2-nitrophenyl)-2-furoate

Severe acute respiratory syndrome-related coronavirus

0.0005

5-chloropyridin-3-yl 5-(3-nitrophenyl)-2-furoate

Severe acute respiratory syndrome-related coronavirus

0.000122

5-chloropyridin-3-yl 5-(4-chloro-2-nitrophenyl)-2-furoate

Severe acute respiratory syndrome-related coronavirus

0.000063

5-chloropyridin-3-yl 5-(4-chlorophenyl)-2-furoate

Severe acute respiratory syndrome-related coronavirus

0.00006

5-chloropyridin-3-yl 5-(4-nitrophenyl)-2-furoate

Severe acute respiratory syndrome-related coronavirus

0.000164

5-chloropyridin-3-yl isonicotinate

Severe acute respiratory syndrome-related coronavirus

0.000697

5-chloropyridin-3-yl nicotinate

Severe acute respiratory syndrome-related coronavirus

0.0005

5-chloropyridin-3-yl thiophene-2-carboxylate

Severe acute respiratory syndrome-related coronavirus

0.006

5-[(4-chlorophenyl)sulfonyl]pyrimidine-2,4-diamine

Severe acute respiratory syndrome-related coronavirus

0.155

acetyl-Ala-Val-Leu-NHCH(CH2CH2CON(CH3)2)-CHO

Severe acute respiratory syndrome-related coronavirus

0.037

acetyl-Ser-Ala-Val-Leu-NHCH(CH2CH2CON(CH3)2)-CHO

Severe acute respiratory syndrome-related coronavirus

0.026

acetyl-Thr-Ser-Ala-Val-Leu-NHCH(CH2CH2CON(CH3)2)-CHO

Severe acute respiratory syndrome-related coronavirus

acetyl-Val-Leu-NHCH(CH2CH2CON(CH3)2)-CHO

Severe acute respiratory syndrome-related coronavirus

0.03745

apigenin-7-O-rhamnoglucoside

Severe acute respiratory syndrome-related coronavirus

pH 6.5, 37°C

754293

0.0022

benzyl ((S)-1-(((S)-1-(((S)-1-(benzo[d]thiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Severe acute respiratory syndrome-related coronavirus

enzyme mutant R188I, pH and temperature not specified in the publication

0.021

benzyl ((S)-1-(((S)-1-(benzo[d]thiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate

Severe acute respiratory syndrome-related coronavirus

enzyme mutant R188I, pH and temperature not specified in the publication

0.01

betulinic acid

Severe acute respiratory syndrome-related coronavirus

681313

0.0026

bis[1,3]thiazolo[4,5-b:5',4'-e]pyridine-2,6-diamine

Severe acute respiratory syndrome-related coronavirus

0.01

Bz-Ala-Val-Leu-Phe-trifluromethyl ketone

Severe acute respiratory syndrome-related coronavirus

enzyme mutant R188I, pH and temperature not specified in the publication

0.0103

celastrol

Severe acute respiratory syndrome-related coronavirus

0.323

cinanserin

Severe acute respiratory syndrome-related coronavirus

0.0119 - 0.04

curcumin

3 entries

0.016

diethyl (2E,2'E)-3,3'-[sulfonylbis(benzene-4,1-diylimino)]bis(2-cyanoprop-2-enoate)

Severe acute respiratory syndrome-related coronavirus

0.0217

dihydrocelastrol

Severe acute respiratory syndrome-related coronavirus

0.0118

ellagic acid

Severe acute respiratory syndrome coronavirus 2

pH 7.3, 25°C

0.0139

epigallocatechin gallate

Severe acute respiratory syndrome coronavirus 2

pH 7.3, 25°C

0.046

esculetin-4-carboxylic acid ethyl ester

Severe acute respiratory syndrome-related coronavirus

678512

0.87

ethyl (2E,4S)-4-[[(2R,5S)-2-benzyl-6-methyl-5-[[(5-methylisoxazol-3-yl)carbonyl]amino]-4-oxoheptanoyl]amino]-5-[(3S)-3-methyl-2-oxopyrrolidin-3-yl]pent-2-enoate

Severe acute respiratory syndrome-related coronavirus

0.08

ethyl (2E,4S)-4-[[(2R,5S)-5-[(N-tert-butyl-L-seryl)amino]-6-methyl-2-(3-methylbut-2-en-1-yl)-4-oxoheptanoyl]amino]-5-[(3S)-3-methyl-2-oxopyrrolidin-3-yl]pent-2-enoate

Severe acute respiratory syndrome-related coronavirus

0.8

ethyl (2E,4S)-4-[[(2R,5S)-6-methyl-2-(3-methylbut-2-en-1-yl)-5-[[(5-methylisoxazol-3-yl)carbonyl]amino]-4-oxoheptanoyl]amino]-5-[(3S)-3-methyl-2-oxopyrrolidin-3-yl]pent-2-enoate

Severe acute respiratory syndrome-related coronavirus

0.00193 - 0.00374

GC376

0.0026

iguesterin

Severe acute respiratory syndrome-related coronavirus

0.007

methyl 4-hydroxy-6-(trifluoromethyl)furo[2,3-b]pyridine-2-carboxylate

Severe acute respiratory syndrome-related coronavirus

0.02

ML300

0.00022

N-(1-benzylpiperidin-4-yl)-2-(N-(4-(tert-butyl)phenyl)vinylsulfonamido)-2-(pyridin-3-yl)acetamide

Severe acute respiratory syndrome coronavirus 2

pH 7.3, 25°C

0.02

N-(2,2'-bithien-5-ylmethyl)-1,3-dimethyl-4-nitro-1H-pyrazol-5-amine

Severe acute respiratory syndrome-related coronavirus

0.0197

N-(2-allylthiophenyl)cinnamide

Severe acute respiratory syndrome-related coronavirus

0.206

N-(2-benzylthiophenyl)cinnamide

Severe acute respiratory syndrome-related coronavirus

0.0135

N-(2-carbomethoxyethylthiophenyl)cinnamide

Severe acute respiratory syndrome-related coronavirus

0.00006

N-(2-chloro-4-nitrophenyl)-Nalpha-[[4-(dimethylamino)phenyl]carbonyl]phenylalaninamide

Severe acute respiratory syndrome-related coronavirus

0.00106

N-(2-cinnamoylthiophenyl)cinnamide

Severe acute respiratory syndrome-related coronavirus

0.062

N-(2-[2-[(2S)-1-cyclohexyl-3-oxopropan-2-yl]hydrazinyl]-4-methylpentanoyl)valyl-N-(1-hydroxy-3,4-dioxopentan-2-yl)alaninamide

Severe acute respiratory syndrome-related coronavirus

in 10 mM Tris-HCl buffer, pH 7.5, containing 7 mM dithiothreitol, at 37°C

N-(2-[2-[(2S)-3,3-dimethyl-1-oxobutan-2-yl]hydrazinyl]-4-methylpentanoyl)valyl-N-(1-hydroxy-3,4-dioxopentan-2-yl)alaninamide

Severe acute respiratory syndrome-related coronavirus

IC50 about 3 mM, in 10 mM Tris-HCl buffer, pH 7.5, containing 7 mM dithiothreitol, at 37°C

0.01

N-(3-methoxyphenyl)glycyl-N-[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-L-leucinamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

731749

0.00098

N-(4-(tert-butyl)phenyl)-2-chloro-N-(2-(cyclohexylamino)-1-(5-methylpyrazin-2-yl)-2-oxoethyl)acetamide

Severe acute respiratory syndrome coronavirus 2

pH 7.3, 25°C

0.00041

N-(4-(tert-butyl)phenyl)-2-chloro-N-(2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl) acetamide

Severe acute respiratory syndrome coronavirus 2

pH 7.3, 25°C

0.00084

N-(4-(tert-butyl)phenyl)-2-chloro-N-(2-(cyclohexylamino)-2-oxo-1-(pyridin-4-yl)ethyl)acetamide

Severe acute respiratory syndrome coronavirus 2

pH 7.3, 25°C

0.00038

N-(4-(tert-butyl)phenyl)-2-chloro-N-(2-(cyclopentylamino)-2-oxo-1-(pyridin-3-yl)ethyl)acetamide

Severe acute respiratory syndrome coronavirus 2

pH 7.3, 25°C

0.00085

N-(4-(tert-butyl)phenyl)-N-(2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl)-4-hydroxybut-2-ynamide

Severe acute respiratory syndrome coronavirus 2

pH 7.3, 25°C

0.02

N-(4-aminophenyl)-2-(1H-benzotriazol-1-yl)-N-[2-(tert-butylamino)-2-oxo-1-(thiophen-3-yl)ethyl]acetamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.048

N-(4-methyl-2-[2-[(2S)-1-oxo-3-(thiophen-2-yl)propan-2-yl]hydrazinyl]pentanoyl)valyl-N-(1-hydroxy-3,4-dioxopentan-2-yl)alaninamide

Severe acute respiratory syndrome-related coronavirus

in 10 mM Tris-HCl buffer, pH 7.5, containing 7 mM dithiothreitol, at 37°C

N-(4-methyl-2-[2-[(2S)-1-oxo-3-phenylpropan-2-yl]hydrazinyl]pentanoyl)valyl-N-(1-hydroxy-3,4-dioxopentan-2-yl)alaninamide

Severe acute respiratory syndrome-related coronavirus

IC50 about 2 mM, in 10 mM Tris-HCl buffer, pH 7.5, containing 7 mM dithiothreitol, at 37°C

0.026

N-(4-[(1H-benzotriazol-1-ylacetyl)[2-(tert-butylamino)-2-oxo-1-(thiophen-3-yl)ethyl]amino]phenyl)-1,2-oxazole-5-carboxamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0225

N-(4-[(1H-benzotriazol-1-ylacetyl)[2-(tert-butylamino)-2-oxo-1-(thiophen-3-yl)ethyl]amino]phenyl)-2,2-dimethylpropanamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0041

N-(4-[(1H-benzotriazol-1-ylacetyl)[2-(tert-butylamino)-2-oxo-1-(thiophen-3-yl)ethyl]amino]phenyl)-2-methylpropanamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0038

N-(4-[(1H-benzotriazol-1-ylacetyl)[2-(tert-butylamino)-2-oxo-1-(thiophen-3-yl)ethyl]amino]phenyl)cyclobutanecarboxamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0091

N-(4-[(1H-benzotriazol-1-ylacetyl)[2-(tert-butylamino)-2-oxo-1-(thiophen-3-yl)ethyl]amino]phenyl)cyclopropanecarboxamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0069

N-(4-[(1H-benzotriazol-1-ylacetyl)[2-(tert-butylamino)-2-oxo-1-(thiophen-3-yl)ethyl]amino]phenyl)propanamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.09072

N-(furan-2-ylmethyl)-2-[[5-(morpholin-4-yl)-1,2,3,4-tetrahydropyrimido[4',5':4,5]thieno[2,3-c]isoquinolin-8-yl]sulfanyl]acetamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.00027

N-acetyl-Ala-Val-Cha-His

Severe acute respiratory syndrome-related coronavirus

in 10 mM Tris-HCl buffer, pH 7.5, containing 7 mM dithiothreitol, at 37°C

0.01

N-acetyl-Asn-Val-Cha-His

Severe acute respiratory syndrome-related coronavirus

in 10 mM Tris-HCl buffer, pH 7.5, containing 7 mM dithiothreitol, at 37°C

0.026

N-acetyl-L-threonyl-N-[(3R,4S,4aR,8aS)-2-(4-bromobenzoyl)-3-([[(2S)-1-(1H-imidazol-4-yl)-3-oxopropan-2-yl]amino]methyl)decahydroisoquinolin-4-yl]glycinamide

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C

752974

0.175

N-acetyl-L-threonyl-N-[(3R,4S,4aR,8aS)-3-([[(2S)-1,1-bis(ethylsulfanyl)-3-(1H-imidazol-4-yl)propan-2-yl]amino]methyl)-2-(4-bromobenzoyl)decahydroisoquinolin-4-yl]glycinamide

Severe acute respiratory syndrome-related coronavirus

pH 7.5, 37°C

752974

0.000065

N-acetyl-Ser-Ala-Val-Cha-His

Severe acute respiratory syndrome-related coronavirus

in 10 mM Tris-HCl buffer, pH 7.5, containing 7 mM dithiothreitol, at 37°C

0.0057

N-acetyl-Ser-Ala-Val-Leu-His

Severe acute respiratory syndrome-related coronavirus

in 10 mM Tris-HCl buffer, pH 7.5, containing 7 mM dithiothreitol, at 37°C

0.33

N-acetyl-Ser-Ala-Val-Leu-NHCH(CH2CH2CON(CH3)2)-CH=CHCOOEt

Severe acute respiratory syndrome-related coronavirus

in 10 mM Tris-HCl buffer, pH 7.5, containing 7 mM dithiothreitol, at 37°C

0.037

N-acetyl-Ser-Ala-Val-Leu-NHCH-(CH2CH2CON(CH3)2)-CHO

Severe acute respiratory syndrome-related coronavirus

in 10 mM Tris-HCl buffer, pH 7.5, containing 7 mM dithiothreitol, at 37°C

0.00039

N-acetyl-Ser-Ala-Val-Phe-His

Severe acute respiratory syndrome-related coronavirus

in 10 mM Tris-HCl buffer, pH 7.5, containing 7 mM dithiothreitol, at 37°C

0.00034

N-acetyl-Ser-Val-Cha-His

Severe acute respiratory syndrome-related coronavirus

in 10 mM Tris-HCl buffer, pH 7.5, containing 7 mM dithiothreitol, at 37°C

0.00098

N-acetyl-Thr-Val-Cha-His

Severe acute respiratory syndrome-related coronavirus

in 10 mM Tris-HCl buffer, pH 7.5, containing 7 mM dithiothreitol, at 37°C

0.00092

N-benzyl-2-(N-(4-(tert-butyl)phenyl)-2-chloroacetamido)-2-(pyridin-3-yl)acetamide

Severe acute respiratory syndrome coronavirus 2

pH 7.3, 25°C

0.015

N-tert-butyl-L-seryl-L-valyl-N-[(1S,2E)-4-ethoxy-1-[[(3S)-3-methyl-2-oxopyrrolidin-3-yl]methyl]-4-oxobut-2-en-1-yl]-L-phenylalaninamide

Severe acute respiratory syndrome-related coronavirus

0.01

N-tert-butyl-L-seryl-L-valyl-N-[(1S,2E)-4-ethoxy-4-oxo-1-[2-(2-oxopyrrolidin-3-yl)ethyl]but-2-en-1-yl]-L-leucinamide

Severe acute respiratory syndrome-related coronavirus

0.07709

N-[(1E)-3-[(2E)-2-(4-hydroxy-3,5-dimethoxybenzylidene)hydrazinyl]-3-oxo-1-phenylprop-1-en-2-yl]benzamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0015

N-[(1R)-2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.04139

N-[(1Z)-3-[[3-(dimethylamino)propyl]amino]-1-[5-(2-nitrophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl]-4-methylbenzamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.03857

N-[(1Z)-3-[[3-(dimethylamino)propyl]amino]-1-[5-(3-nitrophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl]-4-methylbenzamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.2

N-[(5-methyl-4,5-dihydro-1H-pyrazol-3-yl)carbonyl]-L-valyl-N-[(1S,2E)-4-ethoxy-1-[[(3S)-3-methyl-2-oxopyrrolidin-3-yl]methyl]-4-oxobut-2-en-1-yl]-L-leucinamide

Severe acute respiratory syndrome-related coronavirus

0.3

N-[(5-methyl-4,5-dihydro-1H-pyrazol-3-yl)carbonyl]-L-valyl-N-[(1S,2E)-4-ethoxy-1-[[(3S)-3-methyl-2-oxopyrrolidin-3-yl]methyl]-4-oxobut-2-en-1-yl]-L-phenylalaninamide

Severe acute respiratory syndrome-related coronavirus

0.0017

N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-L-leucinamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

731749

0.0095

N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]-1-(1,3-thiazol-2-yl)propan-2-yl]-L-leucinamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

731749

0.0437

N-[2-(2-cyanocinnamoylthio)phenyl]-2-cyanocinnamide

Severe acute respiratory syndrome-related coronavirus

0.293

N-[2-(2-pyridylmethylthio)phenyl]cinnamide

Severe acute respiratory syndrome-related coronavirus

0.125

N-[2-(3-dimethylaminopropylthio)phenyl]-2-cyanocinnamide

Severe acute respiratory syndrome-related coronavirus

0.347

N-[2-(3-pyridylmethylthio)phenyl]cinnamide

Severe acute respiratory syndrome-related coronavirus

0.01

N-[3-(5-tert-butyl-2-methyl-3-furyl)-1H-pyrazol-5-yl]thiophene-2-sulfonamide

Severe acute respiratory syndrome-related coronavirus

0.019 - 0.068

N-[4-(1H-imidazol-4-yl)phenyl]-2-(1H-benzo[d][1,2,3]triazol-1-yl)-N-(3-chlorobenzyl)acetamide

0.27 - 0.334

N-[4-(1H-pyrazol-4-yl)phenyl]-2-(1H-benzo[d][1,2,3]triazol-1-yl)-N-(3-chlorobenzyl)acetamide

0.0007

N-[4-(2-acetylpyridin-3-yl)phenyl]-2-(1H-benzotriazol-1-yl)-N-(thiophen-3-ylmethyl)acetamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0125

N-[4-(2-acetylpyrimidin-5-yl)phenyl]-2-(1H-benzotriazol-1-yl)-N-(thiophen-3-ylmethyl)acetamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0084

N-[4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzyl]-1-ethyl-1H-benzimidazol-2-amine

Severe acute respiratory syndrome-related coronavirus

0.008

N-[4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzyl]-1-propyl-1H-benzimidazol-2-amine

Severe acute respiratory syndrome-related coronavirus

0.0062

N-[4-(acetylamino)phenyl]-2-(1H-benzotriazol-1-yl)-N-[(1R)-2-[(2-methylbutan-2-yl)amino]-1-(1-methyl-1H-pyrrol-3-yl)-2-oxoethyl]acetamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0077

N-[4-(acetylamino)phenyl]-2-(1H-benzotriazol-1-yl)-N-[2-(tert-butylamino)-2-oxo-1-(thiophen-3-yl)ethyl]acetamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.011

N-[4-(acetylamino)phenyl]-N-[2-(tert-butylamino)-2-oxo-1-(thiophen-3-yl)ethyl]-2-(4-phenyl-1H-1,2,3-triazol-1-yl)acetamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0133

N-[4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl]-2,2-dimethylpropanamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0036

N-[4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl]-2-methylpropanamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0034

N-[4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl]-3-methoxypropanamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0081

N-[4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl]cyclobutanecarboxamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0221

N-[4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl]cyclohexanecarboxamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0041

N-[4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl]cyclopropanecarboxamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.0029

N-[4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl]propanamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.015

N-[4-[(4-chlorophenyl)sulfonyl]-3-(methylthio)-1H-pyrazol-5-yl]thiophene-2-carboxamide

Severe acute respiratory syndrome-related coronavirus

0.0002

Nalpha-[(2E)-3-(4-chloro-2-fluorophenyl)prop-2-enoyl]-N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-D-phenylalaninamide

Severe acute respiratory syndrome-related coronavirus

pH and temperature not specified in the publication

0.04

niclosamide

Severe acute respiratory syndrome-related coronavirus

681313

0.0055

pristimerin

Severe acute respiratory syndrome-related coronavirus

0.0234

quercetin

Severe acute respiratory syndrome coronavirus 2

pH 7.3, 25°C

0.0169

resveratrol

Severe acute respiratory syndrome coronavirus 2

pH 7.3, 25°C

0.003

S-[5-(trichloromethyl)-4H-1,2,4-triazol-3-yl] 5-(phenylethynyl)furan-2-carbothioate

Severe acute respiratory syndrome-related coronavirus

0.025

savinin

Severe acute respiratory syndrome-related coronavirus

681313

0.0009

sulfonyldi-4,1-phenylene bis(2,3,3-trichloroacrylate)

Severe acute respiratory syndrome-related coronavirus

0.0318

tafenoquine

Severe acute respiratory syndrome coronavirus 2

pH 7.8, 25°C

765085

0.0009 - 0.0067

tert-butyl [1-[(2S)-1-([(2S)-4-(benzylamino)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]amino)-3-cyclopropyl-1-oxopropan-2-yl]-2-oxo-1,2-dihydropyridin-3-yl]carbamate

0.032

tetraethyl 2,2'-[sulfonylbis(benzene-4,1-diyliminomethylylidene)]dipropanedioate

Severe acute respiratory syndrome-related coronavirus

0.0099

tingenone

Severe acute respiratory syndrome-related coronavirus