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3.4.22.68: Ulp1 peptidase

This is an abbreviated version!
For detailed information about Ulp1 peptidase, go to the full flat file.

Word Map on EC 3.4.22.68

Reaction

Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-/-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein =

Synonyms

C48.001, ELS1, ESD4, PFL1635w, SENP, SENP1, SENP2, SENP6, SENP7, small ubiquitin-like modifier protease, Small ubiquitin-related modifier protein 1 conjugate proteinase, Smt3-protein conjugate proteinase, SMT3IP1, SMT3IP1/SENP3, SUMO deconjugating protease, SUMO protease, SUMO protease 1, SUMO(Smt3)-specific protease, SUMO-specific protease, SUMO-specific protease 2, Ubl-specific protease 1, Ulp1, Ulp1 endopeptidase, Ulp1 protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.68 Ulp1 peptidase

Substrates Products

Substrates Products on EC 3.4.22.68 - Ulp1 peptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
His6-Smt3-hemagglutinin fusion protein + H2O
?
show the reaction diagram
-
-
-
?
His6-Smt3-Leu-beta-galactosidase + H2O
?
show the reaction diagram
-
-
-
?
His6-Smt3-Met-beta-galactosidase + H2O
?
show the reaction diagram
-
-
-
?
small ubiquitin-like modifier protein + H2O
?
show the reaction diagram
small ubiquitin-related modifier-CENP-I + H2O
small ubiquitin-related modifier-protein + CENP-I
show the reaction diagram
-
SUMO-specific proteases, SENPs, reversibly remove small ubiquitin-related modifier-protein, SUMO, from the SUMOylated proteins
-
-
r
small ubiquitin-related modifier-Mdm2 + H2O
small ubiquitin-related modifier-protein + Mdm2
show the reaction diagram
small ubiquitin-related modifier-protein + H2O
small ubiquitin-related modifier-protein + protein
show the reaction diagram
SMT3precursor + H2O
?
show the reaction diagram
-
-
-
-
?
SUMO-1 protein + H2O
?
show the reaction diagram
SUMO-GFP fusion substrate + H2O
SUMO + GFP
show the reaction diagram
pH 8.0, 25°C, in the presence of 5 mM 2-mercaptoethanol
-
-
?
SUMO-MMP13 + H2O
?
show the reaction diagram
cleavage occurs only to 60%
-
-
?
additional information
?
-