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3.4.22.67: zingipain

This is an abbreviated version!
For detailed information about zingipain, go to the full flat file.

Word Map on EC 3.4.22.67

Reaction

preferential cleavage of peptides with a proline residue at the P2 position =

Synonyms

Bgp, C01.017, cysteine proteinase GP-II, F50, ginger protease, ginger protease II, GP-II, zingibain

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.67 zingipain

Inhibitors

Inhibitors on EC 3.4.22.67 - zingipain

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-chloromercuribenzoate
-
-
Al3+
-
slight inhibition
Ba2+
-
slight inhibition
Ca2+
-
slight inhibition
Cd2+
-
strong inhibition
EDTA
-
about 60% inhibition at 1-10 mM
Fe2+
-
activates at 1 mM, inhibits at 10 mM
iodoacetamide
-
-
iodoacetic acid
-
-
mercurial
-
-
Mn2+
-
slight inhibition
NEM
-
strong inhibition
o-phenanthroline
-
-
trans-epoxysuccinyl-L-leucylamido(4-guanidino)butane
-
-
additional information
-
no activating or inhibitory, but a stabilizing effect by EDTA, no inhibition by K+ and Na+
-