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3.4.22.66: calicivirin

This is an abbreviated version!
For detailed information about calicivirin, go to the full flat file.

Word Map on EC 3.4.22.66

Reaction

endopeptidase with a preference for cleavage when the P1 position is occupied by Glu-/- and the P1' position is occupied by Gly-/- =

Synonyms

3C protease, 3C-like cysteine protease, 3C-like protease, 3C-like proteinase, 3C-like viral protease, 3CL Pro, 3cLpro, 3CP, 3Cpro, C37.001, calicivirus protease, CVP, FCV 3CLpro, NoV 3CLpro, NV 3CLpro, NV protease, NVPro, Pro, PV 3Cpro, Southampton virus 3C-like protease, viral cysteine protease, virus-encoded 3C-like proteinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.66 calicivirin

Inhibitors

Inhibitors on EC 3.4.22.66 - calicivirin

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2S)-2-([N-[(benzyloxy)carbonyl]-L-leucyl]amino)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonic acid
1,6-di(propan-2-yl)-N-(4-[[4-(prop-2-en-1-yl)-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl]methyl]-1,3-thiazol-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
-
compound is predicted to bind to feline calicivirus proteases in a mode similar to that of the authentic substrate, and has the ability to inhibit viral protease activity in vitro and in the cells, and to suppress viral replication in FCV-infected cells. The authentic substrate and anti-FCV compound share a highly conserved binding site
2-mercaptoethanol
-
20% inhibited by 0.01 mM, 40% inhibited by 5 mM
4-(2-aminoethyl)-benzene-sulfonyl fluoride
irreversible inhibition, soluble stable nontoxic alternative to phenylmethylsulfonyl fluoride
benzyl ((3S,6S,9S,Z)-6-(cyclohexylmethyl)-9-formyl-4,7,12-trioxo-11H-5,8,13-triaza-1(4,1)-triazolacyclohexadecaphane-3-yl)carbamate
-
benzyl ((3S,6S,9S,Z)-9-formyl-6-isobutyl-4,7,12-trioxo-11H-5,8,13-triaza-1(4,1)-triazolacyclohexadecaphane-3-yl)carbamate
-
benzyl ((8S,11S,14S,Z)-11-(cyclohexylmethyl)-8-formyl-5,10,13-trioxo-11H-4,9,12-triaza-1(1,4)-triazolacyclopentadecaphane-14-yl)carbamate
-
benzyl [(2S)-1-[[(2S)-3-methyl-1-oxo-1-([(2S)-1-oxo-3-[(1S)-2-oxocyclopentyl]propan-2-yl]amino)butan-2-yl]amino]-3-(naphthalen-1-yl)-1-oxopropan-2-yl]carbamate
Hg2+
-
5 mM completely inhibits
K+
-
inhibited by 100 mM
L-Leu-Gly-Gly
-
-
methyl methanethiosulfonate
-
almost complete inhibition
N-ethylmaleimide
-
almost complete inhibition
N-Phenylmaleimide
-
almost complete inhibition
N2-[(benzyloxy)carbonyl]-N-[(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]-1-(sulfinooxy)propan-2-yl]-L-valinamide
N2-[(benzyloxy)carbonyl]-N-[(2S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl]-L-leucinamide
N2-[(benzyloxy)carbonyl]-N-[(2S)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)-4-(propan-2-ylamino)butan-2-yl]-L-leucinamide
Na+
-
83% inhibited by 100 mM
p-chloromercuribenzenesulfonate
-
27% inhibited by 0.01 mM
p-chloromercuribenzoic acid
-
82% inhibited by 0.01 mM
phenyl methylsulfonylfluoride
-
20% inhibition by 0.01 mM
phenylmethylsulfonyl fluoride
-
rupintrivir
zinc N-ethyl-N-phenyldithiocarbamate
-
-
Zn2+
-
5 mM completely inhibits
additional information
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