3.4.22.65: peptidase 1 (mite)

This is an abbreviated version!
For detailed information about peptidase 1 (mite), go to the full flat file.

Word Map on EC 3.4.22.65

3.4.22.65

allergic

asthma

ige

dermatophagoides

pteronyssinus

children

home

asthmatic

atopic

farinae

airway

indoor

immunotherapy

mattress

bronchial

rhinitis

inhale

prick

allergen-specific

floor

carpet

bedroom

dermatitis

humid

hyperresponsiveness

airborne

household

houses

cockroach

aeroallergens

vacuum

wheeze

house-dust

ige-binding

cleaner

ras

blomia

anti-der

allergen-induced

rhinoconjunctivitis

component-resolved

mite-induced

radioallergosorbent

diagnostics

hdm-induced

hypoallergenic

pharmacology

nonatopic

medicine

wheal

immunocap

dander

skin-prick

drug development

Reaction

broad endopeptidase specificity =

Synonyms

allergen Der f 1, allergen Der f1, allergen Der p, allergen Der p 1, allergen Der p1, CO1.073, Der f 1, Der f1, Der p 1, Der p 7, Der p1, dust mite allergen Der p 7, dust mite peptidase allergen Der p 1, house dust mite allergen, house dust mite allergens, major house dust mite allergen, mite allergen, mite major group 1 allergens, pro-Der f1, ProDer f 1, ProDer p 1

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.65 peptidase 1 (mite)

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Results	in table
6	Activating Compound
16	AA Sequence
23	Application
32	Cloned(Commentary)
1	Cofactor
4	Crystallization (Commentary)
16	General Information
1	General Stability
45	IC50 Value
75	Inhibitors
5	Ki Value [mM]
5	KM Value [mM]
2	Metals/Ions
15	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
62	Organism
2	PDB ID
2	pH Optimum
1	pI Value
15	Posttranslational Modification
27	Protein Variants
23	Purification (Commentary)
2	Reaction
1	Reaction Type
61	Reference
5	Renatured (Commentary)
5	Source Tissue
66	Substrates and Products (Substrate)
17	Subunits
60	Synonyms
2	Temperature Optimum [°C]
1	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.22.65 - peptidase 1 (mite)

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0.000003

(3S)-3-([N-[(2S)-3,3-dimethyl-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanoyl]-L-alanyl]amino)-4-methyl-2-oxo-N-(4-sulfamoylbenzyl)pentanamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000007

(3S)-N-benzyl-3-([N-[(2S)-3,3-dimethyl-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanoyl]-L-alanyl]amino)-4-methyl-2-oxopentanamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000004

(3S)-N-[4-[(dimethylamino)methyl]benzyl]-3-([N-[(2S)-3,3-dimethyl-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanoyl]-L-alanyl]amino)-4-methyl-2-oxopentanamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.00002

3-methyl-N-(naphthalen-1-ylcarbonyl)-L-valyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000013

3-methyl-N-(pyridin-4-ylcarbonyl)-L-valyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000018

3-methyl-N-(quinolin-4-ylcarbonyl)-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000013

3-methyl-N-(quinolin-4-ylcarbonyl)-L-valyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000003

3-methyl-N-(quinolin-4-ylcarbonyl)-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-([2-oxo-2-[4-(propan-2-yl)piperazin-1-yl]ethyl]amino)pentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.00019

3-methyl-N-[(1-methylpiperidin-4-yl)carbonyl]-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000004

4-([[(3S)-3-([N-[(2S)-3,3-dimethyl-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanoyl]-L-alanyl]amino)-4-methyl-2-oxopentanoyl]amino]methyl)-N-methylbenzamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000051 - 0.0000569

Der p 1 prodomain

show

-

0.00002

N-(naphthalen-1-ylcarbonyl)-L-phenylalanyl-N-[(3S)-4-methyl-1-[[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino]-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000009

N-benzoyl-3-methyl-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000014

N-benzoyl-3-methyl-L-valyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000017

N-benzoyl-3-methyl-L-valyl-N-[(3S)-1-(cyclopropylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000008

N-benzoyl-3-methyl-L-valyl-N-[(3S)-1-([4-[(dimethylamino)methyl]benzyl]amino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000006

N-benzoyl-3-methyl-L-valyl-N-[(3S)-1-amino-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000011

N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-[(1H-pyrazol-4-ylmethyl)amino]pentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000006

N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-[(4-sulfamoylbenzyl)amino]pentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000117

N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-[[(1R)-1-phenylethyl]amino]pentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000017

N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-[[(1S)-1-phenylethyl]amino]pentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000047

N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-[[4-(trifluoromethyl)benzyl]amino]pentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000024

N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1-(methylamino)-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000014

N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1-[[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino]-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000042

N-benzoyl-b,b-dimethyl-L-phenylalanyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000997

N-benzoyl-L-phenylalanyl-N-[(3S)-1,2-dioxo-1-(pyrrolidin-1-yl)heptan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000012

N-benzoyl-L-phenylalanyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000008 - 0.000017

N-benzoyl-L-phenylalanyl-N-[(3S)-1-(cyclohexylamino)-1,2-dioxoheptan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.00917

N-benzoyl-L-phenylalanyl-N-[(3S)-1-(cyclohexylamino)-4,4-dimethyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000018

N-benzoyl-L-phenylalanyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000164

N-benzoyl-L-phenylalanyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-norvalinamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000006

N-benzoyl-L-phenylalanyl-N-[(3S)-1-[[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]amino]-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000017

N-benzoyl-L-phenylalanyl-N-[(3S)-1-[[2-(4,4-dimethylpiperazin-4-ium-1-yl)-2-oxoethyl]amino]-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000065

N-benzoyl-L-phenylalanyl-N-[(3S)-2-oxo-1-(pyrrolidin-1-yl)heptan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000055

N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1,2-dioxo-1-(tetrahydro-2H-pyran-4-ylamino)pentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000004

N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1,2-dioxo-1-([2-oxo-2-[4-(propan-2-yl)piperazin-1-yl]ethyl]amino)pentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000014

N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1,2-dioxo-1-[[2-oxo-2-(piperidin-1-yl)ethyl]amino]pentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000115

N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1-[(1-methylpiperidin-4-yl)amino]-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.00001

N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1-[[(2S)-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]amino]-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000014

N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1-[[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino]-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000009

N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1-[[2-(morpholin-4-yl)-2-oxoethyl]amino]-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000006

N-[(1,1-dimethylpiperidinium-4-yl)carbonyl]-3-methyl-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000005

N-[(1S)-2-[[(2S)-1-[[(3S)-4-methyl-1-[[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino]-1,2-dioxopentan-3-yl]amino]-1-oxopropan-2-yl]amino]-2-oxo-1-(tricyclo[3.3.1.13,7]dec-1-yl)ethyl]benzamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

0.000067

N-[(3,5-dimethyl-1H-pyrazol-4-yl)carbonyl]-3-methyl-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide

Dermatophagoides pteronyssinus

pH and temperature not specified in the publication

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Release 2023.1 (January 2023)