3.4.22.65: peptidase 1 (mite)
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For detailed information about peptidase 1 (mite), go to the full flat file.
Word Map on EC 3.4.22.65
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3.4.22.65
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allergic
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asthma
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ige
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dermatophagoides
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pteronyssinus
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children
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home
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asthmatic
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atopic
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farinae
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airway
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indoor
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immunotherapy
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mattress
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bronchial
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rhinitis
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inhale
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prick
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allergen-specific
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floor
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carpet
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bedroom
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dermatitis
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humid
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hyperresponsiveness
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airborne
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household
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houses
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cockroach
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aeroallergens
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vacuum
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wheeze
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house-dust
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ige-binding
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cleaner
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ras
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blomia
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anti-der
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allergen-induced
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rhinoconjunctivitis
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component-resolved
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mite-induced
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radioallergosorbent
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diagnostics
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hdm-induced
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hypoallergenic
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pharmacology
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nonatopic
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medicine
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wheal
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immunocap
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dander
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skin-prick
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drug development
- 3.4.22.65
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allergic
- asthma
- ige
- dermatophagoides
- pteronyssinus
- children
-
home
-
asthmatic
-
atopic
- farinae
- airway
-
indoor
-
immunotherapy
-
mattress
- bronchial
- rhinitis
-
inhale
-
prick
-
allergen-specific
-
floor
-
carpet
-
bedroom
- dermatitis
-
humid
-
hyperresponsiveness
-
airborne
-
household
-
houses
- cockroach
-
aeroallergens
-
vacuum
-
wheeze
-
house-dust
-
ige-binding
-
cleaner
- ras
- blomia
-
anti-der
-
allergen-induced
-
rhinoconjunctivitis
-
component-resolved
-
mite-induced
-
radioallergosorbent
- diagnostics
-
hdm-induced
-
hypoallergenic
- pharmacology
-
nonatopic
- medicine
-
wheal
-
immunocap
-
dander
-
skin-prick
- drug development
Reaction
broad endopeptidase specificity =
Synonyms
allergen Der f 1, allergen Der f1, allergen Der p, allergen Der p 1, allergen Der p1, CO1.073, Der f 1, Der f1, Der p 1, Der p 7, Der p1, dust mite allergen Der p 7, dust mite peptidase allergen Der p 1, house dust mite allergen, house dust mite allergens, major house dust mite allergen, mite allergen, mite major group 1 allergens, pro-Der f1, ProDer f 1, ProDer p 1
ECTree
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Application
Application on EC 3.4.22.65 - peptidase 1 (mite)
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diagnostics
drug development
the enzyme is a target for design and development of specific inhibitors for treatment of allergic asthma
medicine
pharmacology
production of recombinant enzymatically and immunologically enzyme for deciphering of immunotherapy mechanisms
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maturation systems using Pro-Der p 1 without the prodomain glycosylation are useful for the efficient preparation of a recombinant mature allergen
diagnostics
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suspension-cultured BY-2 tobacco cells represent a low cost and environmentally safe expression system suitable to produce recombinant allergens from Dermatophagoides pteronyssinus under a form appropriate for diagnostic and therapeutic purposes
diagnostics
possible development of diagnostic allergy tests based on in planta produced allergens using Der 1 p as prototype
diagnostics
production of recombinant enzymatically and immunologically enzyme for diagnostic testing
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the efficient system to prepare active recombinant enzyme is useful for diagnosis and standardized allergen-specific immunotherapy for house dust mite allergy. The system would by a tool for analysis of IgE epitopes, determination of tertiary structure, allergen engineering for safer and more effective allergen-specific immunotherapy
medicine
affects individuals with allergy, resulting in rhinitis, asthma and/or atopic dermatitits
medicine
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allergen is associated with allergic diseases such as bronchial asthma, rhinitis, and atopic dermatitis
medicine
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induces biological responses in a human airway-derived epithelial cell line
medicine
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contribution of Der f 1 is particularly relevant in the mattresses and much less so in floor dust from the bedroom or living room, mattress covers (Goratex bedding system) seem to be an obvious option for lowering allergen exposure in sensitized individuals, geographical differences in prevelance of Dermatophagoides farinae in the Netherlands
medicine
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cystatin A produced by keratinocytes is the dominant biochemical skin barrier against mite cysteine proteases
medicine
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Der f 1 is one of the most potent indoor allergens from house dust mites, shows IgE-eliciting activity in mice, recombinant DER f 1-N53Q will be a useful tool as alternatives to the natural Der f1 for in vitro and in vivo analyses
medicine
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prodomains of Der f 1 reduce allergenicity, decreased activity of the proforms in inhibiting IgE binding, proforms exhibit different secondary structures than the mature forms, major conformational IgE epitopes commonly found in a broad population of patients exist within the 2 regions blocked by the prosegments, results basis for allergen standardization and design of safer and more effective allergen vaccines
medicine
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upholstered seats in workplaces in Italy may constitue a significant reservoir of Der f1, significant correlation between indoor temperature and Der f 1 levels on floors, expressed per surface (no correlation when levels were expressed per weight), no correlation between concentration of mite allergen and geographical location, floor above ground, type of ventilation and indoor humidity, exposure to this allergen in workplaces may represent a risk factor for elicitation of symptoms and/or induction/maintenance of inflammation in allergic individuals and for sensitization
medicine
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mimotopes identify conformational B-cell epitopes on the house dust mite allergen Der p 1. These mimotopes are potential candidates for the directed induction of blocking antibodies and epitope-specific immunotherapy of mite allergy
medicine
chimeras assembling Der p 1 and Der p 2 allergens are potential candidate vaccines against house dust mite allergy. But significant solubility and stability issues can limit the application of such chimeras for immunotherapy or diagnostic
medicine
production of recombinant enzyme for allergen-specific immunotherapy