3.4.22.64: caspase-11
This is an abbreviated version!
For detailed information about caspase-11, go to the full flat file.
Word Map on EC 3.4.22.64
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3.4.22.64
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inflammasome
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pyroptosis
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lps
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lipopolysaccharide
-
non-canonical
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gasdermin
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sepsis
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gsdmd
-
interleukin-1
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lps-induced
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pyrin
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casp11
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apoptosis-associated
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nod-like
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caspase-5
-
pore-forming
-
speck-like
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guanylate-binding
-
inflammasome-mediated
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wedelolactone
-
rodentium
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pyroptosis-related
-
inflammasome-dependent
-
caspase-1/11
-
caspase-1-mediated
-
bmdms
-
speck
-
thailandensis
-
medicine
- 3.4.22.64
- inflammasome
-
pyroptosis
- lps
- lipopolysaccharide
-
non-canonical
-
gasdermin
- sepsis
-
gsdmd
- interleukin-1
-
lps-induced
- pyrin
-
casp11
-
apoptosis-associated
-
nod-like
- caspase-5
-
pore-forming
-
speck-like
-
guanylate-binding
-
inflammasome-mediated
- wedelolactone
- rodentium
-
pyroptosis-related
-
inflammasome-dependent
-
caspase-1/11
-
caspase-1-mediated
-
bmdms
-
speck
- thailandensis
- medicine
Reaction
strict requirement for Asp at the P1 position and has a preferred cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp-/- =
Synonyms
C14.012, CASP4, caspase 11, caspase-11, caspase-4, Ich-3, ICH-3 protease
ECTree
3.4.22.64 caspase-11Advanced search results
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Reference on EC 3.4.22.64 - caspase-11
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chang, H.Y.; Yang, X.
Proteases from cell suicide: functions and regulation of caspases
Microbiol. Mol. Biol. Rev.
64
821-846
2000
Mus musculus
van de Craen, M.; Vandenabeele, P.; Declercq, W.; van den Brande, I.; van Loo, G.; Molemans, F.; Schotte, P.; van Criekinge, W.; Beyaert, R.; Fiers, W.
Characterization of seven murine caspase family members
FEBS Lett.
403
61-69
1997
Mus musculus (P70343), Mus musculus C3H/An (P70343)
Wang, S.; Miura, M.; Jung, Y.K.; Zhu, H.; Gagliardini, V.; Shi, L.; Greenberg, A.H.; Yuan, J.
Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE
J. Biol. Chem.
271
20580-20587
1996
Mus musculus (P70343), Mus musculus, Mus musculus C57BL/6 X CBA (P70343)
Wang, S.; Miura, M.; Jung, Y.K.; Zhu, H.; Li, E.; Yuan, J.
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE
Cell
92
501-509
1998
Mus musculus
Kang, S.J.; Wang, S.; Hara, H.; Peterson, E.P.; et al.
Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions
J. Cell Biol.
149
613-622
2000
Mus musculus
Kang, K.; Oh, Y.K.; Choue, R.; Kang, S.J.
Scutellariae radix extracts suppress ethanol-induced caspase-11 expression and cell death in N(2)a cells
Brain Res. Mol. Brain Res.
142
139-145
2005
Mus musculus
Hur, J.; Kim, S.Y.; Kim, H.; Cha, S.; Lee, M.S.; Suk, K.
Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway
FEBS Lett.
507
157-162
2001
Rattus norvegicus (Q91XW7)
Arai, H.; Furuya, T.; Yasuda, T.; Miura, M.; Mizuno, Y.; Mochizuki, H.
Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice
J. Biol. Chem.
279
51647-51653
2004
Mus musculus
Endo, M.; Mori, M.; Akira, S.; Gotoh, T.
C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation
J. Immunol.
176
6245-6253
2006
Mus musculus
Furuya, T.; Hayakawa, H.; Yamada, M.; Yoshimi, K.; Hisahara, S.; Miura, M.; Mizuno, Y.; Mochizuki, H.
Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinsons disease
J. Neurosci.
24
1865-1872
2004
Mus musculus
Li, J.; Yin, H.L.; Yuan, J.
Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity
J. Cell Biol.
181
321-333
2008
Mus musculus
Bailly, M.
Moving away from death: when caspase-11 meets cofilin
Nat. Cell Biol.
9
245-246
2007
Mus musculus
Li, J.; Brieher, W.M.; Scimone, M.L.; Kang, S.J.; Zhu, H.; Yin, H.; von Andrian, U.H.; Mitchison, T.; Yuan, J.
Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization
Nat. Cell Biol.
9
276-286
2007
Mus musculus
Namba, T.; Tanaka, K.I.; Ito, Y.; Ishihara, T.; Hoshino, T.; Gotoh, T.; Endo, M.; Sato, K.; Mizushima, T.
Positive Role of CCAAT/Enhancer-Binding Protein Homologous Protein, a Transcription Factor Involved in the Endoplasmic Reticulum Stress Response in the Development of Colitis
Am. J. Pathol.
174
1786-1798
2009
Mus musculus (P70343)
Yi, J.Y.; Hirabayashi, Y.; Choi, Y.K.; Kodama, Y.; Kanno, J.; Han, J.H.; Inoue, T.; Yoon, B.I.
Benzene activates caspase-4 and -12 at the transcription level, without an association with apoptosis, in mouse bone marrow cells lacking the p53 gene
Arch. Toxicol.
83
795-803
2009
Mus musculus
Suyama, K.; Ohmuraya, M.; Hirota, M.; Ozaki, N.; Ida, S.; Endo, M.; Araki, K.; Gotoh, T.; Baba, H.; Yamamura, K.
C/EBP homologous protein is crucial for the acceleration of experimental pancreatitis
Biochem. Biophys. Res. Commun.
367
176-182
2008
Mus musculus (P70343)
Heo, H.; Yoo, L.; Shin, K.S.; Kang, S.J.
Suppression of caspase-11 expression by histone deacetylase inhibitors
Biochem. Biophys. Res. Commun.
378
79-83
2009
Mus musculus
Lee, J.M.; Kim, Y.J.; Ra, H.; Kang, S.J.; Han, S.; Koh, J.Y.; Kim, Y.H.
The involvement of caspase-11 in TPEN-induced apoptosis
FEBS Lett.
582
1871-1876
2008
Mus musculus
Ra, H.; Kim, H.L.; Lee, H.W.; Kim, Y.H.
Essential role of p53 in TPEN-induced neuronal apoptosis
FEBS Lett.
583
1516-1520
2009
Mus musculus
Bulosan, M.; Pauley, K.M.; Yo, K.; Chan, E.K.; Katz, J.; Peck, A.B.; Cha, S.
Inflammatory caspases are critical for enhanced cell death in the target tissue of Sjoegrens syndrome before disease onset
Immunol. Cell Biol.
87
81-90
2009
Mus musculus
Melcher, M.; Unger, B.; Schmidt, U.; Rajantie, I.A.; Alitalo, K.; Ellmeier, W.
Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival
J. Immunol.
180
8048-8056
2008
Mus musculus
de Rivero Vaccari, J.P.; Lotocki, G.; Marcillo, A.E.; Dietrich, W.D.; Keane, R.W.
A molecular platform in neurons regulates inflammation after spinal cord injury
J. Neurosci.
28
3404-3414
2008
Rattus norvegicus (Q91XW7)
Choi, J.R.; Heo, H.; Lang, Y.; Shin, K.S.; Kang, S.J.
Apoptosis signal-regulating kinase 1 regulates the expression of caspase-11
FEBS Lett.
583
3016-3020
2009
Mus musculus
de Rivero Vaccari, J.P.; Lotocki, G.; Alonso, O.F.; Bramlett, H.M.; Dietrich, W.D.; Keane, R.W.
Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury
J. Cereb. Blood Flow Metab.
29
1251-1261
2009
Rattus norvegicus
Fradejas, N.; Pastor, M.D.; Burgos, M.; Beyaert, R.; Tranque, P.; Calvo, S.
Caspase-11 mediates ischemia-induced astrocyte death: involvement of endoplasmic reticulum stress and C/EBP homologous protein
J. Neurosci. Res.
88
1094-1105
2010
Rattus norvegicus
Ayuso, M.I.; Garcia-Bonilla, L.; Martin, M.E.; Salinas, M.
Assessment of protein expression levels after transient global cerebral ischemia using an antibody microarray analysis
Neurochem. Res.
35
1239-1247
2010
Rattus norvegicus
Yoo, L.; Hong, S.; Shin, K.S.; Kang, S.J.
PARP-1 regulates the expression of caspase-11
Biochem. Biophys. Res. Commun.
408
489-493
2011
Homo sapiens
Kayagaki, N.; Warming, S.; Lamkanfi, M.; Vande Walle, L.; Louie, S.; Dong, J.; Newton, K.; Qu, Y.; Liu, J.; Heldens, S.; Zhang, J.; Lee, W.P.; Roose-Girma, M.; Dixit, V.M.
Non-canonical inflammasome activation targets caspase-11
Nature
479
117-121
2011
Mus musculus, Mus musculus C57BL/6
Shin, S.; Brodsky, I.E.
Caspase-11: the noncanonical guardian of cytosolic sanctity
Cell Host Microbe
13
243-245
2013
Mus musculus
Ng, T.M.; Monack, D.M.
Revisiting caspase-11 function in host defense
Cell Host Microbe
14
9-14
2013
Homo sapiens, Mus musculus
Py, B.F.; Jin, M.; Desai, B.N.; Penumaka, A.; Zhu, H.; Kober, M.; Dietrich, A.; Lipinski, M.M.; Henry, T.; Clapham, D.E.; Yuan, J.
Caspase-11 controls interleukin-1beta release through degradation of TRPC1
Cell Rep.
6
1122-1128
2014
Mus musculus, Mus musculus C57B6
Vigano, E.; Mortellaro, A.
Caspase-11: the driving factor for noncanonical inflammasomes
Eur. J. Immunol.
43
2240-2245
2013
Homo sapiens, Mus musculus
Stowe, I.; Lee, B.; Kayagaki, N.
Caspase-11: arming the guards against bacterial infection
Immunol. Rev.
265
75-84
2015
Mus musculus
Case, C.L.; Kohler, L.J.; Lima, J.B.; Strowig, T.; de Zoete, M.R.; Flavell, R.A.; Zamboni, D.S.; Roy, C.R.
Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila
Proc. Natl. Acad. Sci. USA
110
1851-1856
2013
Mus musculus, Mus musculus C57BL/6
Aachoui, Y.; Leaf, I.A.; Hagar, J.A.; Fontana, M.F.; Campos, C.G.; Zak, D.E.; Tan, M.H.; Cotter, P.A.; Vance, R.E.; Aderem, A.; Miao, E.A.
Caspase-11 protects against bacteria that escape the vacuole
Science
339
975-978
2013
Mus musculus, Mus musculus C57BL/6
Huang, W.; Xie, W.B.; Qiao, D.; Qiu, P.; Huang, E.; Li, B.; Chen, C.; Liu, C.; Wang, Q.; Lin, Z.; Wang, H.
Caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis
Toxicol. Sci.
145
68-79
2015
Homo sapiens, Rattus norvegicus, Rattus norvegicus Sprague Dawley
Allen, J.; Gyorke, C.E.; Tripathy, M.K.; Zhang, Y.; Lovett, A.; Montgomery, S.A.; Nagarajan, U.M.
Caspase-11 contributes to oviduct pathology during genital Chlamydia infection in mice
Infect. Immun.
87
e00262
2019
Mus musculus (P70343), Mus musculus
Lee, B.L.; Stowe, I.B.; Gupta, A.; Kornfeld, O.S.; Roose-Girma, M.; Anderson, K.; Warming, S.; Zhang, J.; Lee, W.P.; Kayagaki, N.
Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation
J. Exp. Med.
215
2279-2288
2018
Mus musculus (P70343), Mus musculus
Sun, Y.; Abbondante, S.; Karmakar, M.; De Jesus Carrion, S.; Che, C.; Hise, A.; Pearlman, E.
Neutrophil caspase-11 is required for cleavage of caspase-1 and secretion of IL-1beta in Aspergillus fumigatus infection
J. Immunol.
201
2767-2775
2018
Mus musculus (P70343)
Kayagaki, N.; Stowe, I.B.; Lee, B.L.; ORourke, K.; Anderson, K.; Warming, S.; Cuellar, T.; Haley, B.; Roose-Girma, M.; Phung, Q.T.; Liu, P.S.; Lill, J.R.; Li, H.; Wu, J.; Kummerfeld, S.; Zhang, J.; Lee, W.P.; Snipas, S.J.; Salvesen, G.S.; Morris, L.X.; Fitzgerald, L.; Zhang, Y.; Bertram, E.M.; Goodnow, C.C.; Di, D.i.x.
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nature
526
666-671
2015
Mus musculus (P70343), Mus musculus
Flood, B.; Manils, J.; Nulty, C.; Flis, E.; Kenealy, S.; Barber, G.; Fay, J.; Mills, K.H.G.; Kay, E.W.; Creagh, E.M.
Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis
Oncogene
38
2658-2674
2019
Mus musculus (P70343), Mus musculus
Aglietti, R.A.; Estevez, A.; Gupta, A.; Ramirez, M.G.; Liu, P.S.; Kayagaki, N.; Ciferri, C.; Dixit, V.M.; Dueber, E.C.
GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes
Proc. Natl. Acad. Sci. USA
113
7858-7863
2016
Homo sapiens
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