3.4.22.64: caspase-11
This is an abbreviated version!
For detailed information about caspase-11, go to the full flat file.
Word Map on EC 3.4.22.64
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3.4.22.64
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inflammasome
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pyroptosis
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lps
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lipopolysaccharide
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non-canonical
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gasdermin
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sepsis
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gsdmd
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interleukin-1
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lps-induced
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pyrin
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casp11
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apoptosis-associated
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nod-like
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caspase-5
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pore-forming
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speck-like
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guanylate-binding
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inflammasome-mediated
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wedelolactone
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rodentium
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pyroptosis-related
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inflammasome-dependent
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caspase-1/11
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caspase-1-mediated
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bmdms
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speck
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thailandensis
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medicine
- 3.4.22.64
- inflammasome
-
pyroptosis
- lps
- lipopolysaccharide
-
non-canonical
-
gasdermin
- sepsis
-
gsdmd
- interleukin-1
-
lps-induced
- pyrin
-
casp11
-
apoptosis-associated
-
nod-like
- caspase-5
-
pore-forming
-
speck-like
-
guanylate-binding
-
inflammasome-mediated
- wedelolactone
- rodentium
-
pyroptosis-related
-
inflammasome-dependent
-
caspase-1/11
-
caspase-1-mediated
-
bmdms
-
speck
- thailandensis
- medicine
Reaction
strict requirement for Asp at the P1 position and has a preferred cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp-/- =
Synonyms
C14.012, CASP4, caspase 11, caspase-11, caspase-4, Ich-3, ICH-3 protease
ECTree
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Posttranslational Modification
Posttranslational Modification on EC 3.4.22.64 - caspase-11
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proteolytic modification
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the enzyme requires activation through proteolytic cleavage
proteolytic modification
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TRIF is required for the processing of procaspase-11 into the cleaved caspase-11 forms
proteolytic modification
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the adaptor protein TRIF upregulates procaspase-11 expression, and this upregulation is required for caspase-11 processing and activation
proteolytic modification
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TRIF is required for the processing of procaspase-11 into the cleaved caspase-11 forms. IFNs or lipopolyaccharides alone are not sufficient to trigger caspase-11 processing, but an unidentified factor derived from live Gram-negative bacteria is required, which is likely a mechanism to ensure that inflammatory responses do not proceed in the absence of active infection
proteolytic modification
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the enzyme requires activation through proteolytic cleavage
proteolytic modification
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the enzyme requires activation through proteolytic cleavage
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