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3.4.22.64: caspase-11

This is an abbreviated version!
For detailed information about caspase-11, go to the full flat file.

Word Map on EC 3.4.22.64

Reaction

strict requirement for Asp at the P1 position and has a preferred cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp-/- =

Synonyms

C14.012, CASP4, caspase 11, caspase-11, caspase-4, Ich-3, ICH-3 protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.64 caspase-11

Expression

Expression on EC 3.4.22.64 - caspase-11

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
bacterial lipopolysaccharide stimulation of caspase-11 expression in several mouse tissues, particularly in the spleen
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cytosolic infection of cells with Burkholderia species and cytyosolic mutants of Salmonella typhimurium and Legionella pneumophila trigger the enzyme
induction of caspase-11 is dependent on NF-kappaB. PARP-1 participates in the activation of caspase-11 promoter as a coactivator of NF-kappaB. Lipopolysaccharide induce the enzyme expression
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induction of procaspase-11 expression is delayed in Myd88-/- macrophages infected with DELTAFlag Salmonella typhimurium, although procaspase-11 processing itself remains intact
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ischemia induces expression in astrocytes
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Lipopolysaccharide treatment or type I IFN treatment alone does not cause caspase-11-dependent cell death
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poly(ADP-ribose) polymerase-1, PARP-1, regulates the expression of caspase-11 following lipopolysaccharide stimulation. PARP-1 is recruited to the caspase-11 promoter region containing predicted nuclear factor (NF)-kappaB-binding sites, but PARP-1 enzymatic activity is not required for the caspase-11 upregulation. PARP-1 can regulate the induction of caspase-11 at a transcriptional level. PARP-1 participates in the activation of caspase-11 promoter as a coactivator of NF-kappaB
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type I IFN signaling is sufficient to induce caspase-11 upregulation and processing. The adaptor protein TRIF upregulates procaspase-11 expression, and this upregulation is required for caspase-11 processing and activation
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