3.4.22.64: caspase-11
This is an abbreviated version!
For detailed information about caspase-11, go to the full flat file.
Word Map on EC 3.4.22.64
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3.4.22.64
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inflammasome
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pyroptosis
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lps
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lipopolysaccharide
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non-canonical
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gasdermin
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sepsis
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gsdmd
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interleukin-1
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lps-induced
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pyrin
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casp11
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apoptosis-associated
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nod-like
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caspase-5
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pore-forming
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speck-like
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guanylate-binding
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inflammasome-mediated
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wedelolactone
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rodentium
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pyroptosis-related
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inflammasome-dependent
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caspase-1/11
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caspase-1-mediated
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bmdms
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speck
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thailandensis
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medicine
- 3.4.22.64
- inflammasome
-
pyroptosis
- lps
- lipopolysaccharide
-
non-canonical
-
gasdermin
- sepsis
-
gsdmd
- interleukin-1
-
lps-induced
- pyrin
-
casp11
-
apoptosis-associated
-
nod-like
- caspase-5
-
pore-forming
-
speck-like
-
guanylate-binding
-
inflammasome-mediated
- wedelolactone
- rodentium
-
pyroptosis-related
-
inflammasome-dependent
-
caspase-1/11
-
caspase-1-mediated
-
bmdms
-
speck
- thailandensis
- medicine
Reaction
strict requirement for Asp at the P1 position and has a preferred cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp-/- =
Synonyms
C14.012, CASP4, caspase 11, caspase-11, caspase-4, Ich-3, ICH-3 protease
ECTree
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Expression
Expression on EC 3.4.22.64 - caspase-11
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bacterial lipopolysaccharide stimulation of caspase-11 expression in several mouse tissues, particularly in the spleen
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cytosolic infection of cells with Burkholderia species and cytyosolic mutants of Salmonella typhimurium and Legionella pneumophila trigger the enzyme
induction of caspase-11 is dependent on NF-kappaB. PARP-1 participates in the activation of caspase-11 promoter as a coactivator of NF-kappaB. Lipopolysaccharide induce the enzyme expression
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induction of procaspase-11 expression is delayed in Myd88-/- macrophages infected with DELTAFlag Salmonella typhimurium, although procaspase-11 processing itself remains intact
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Lipopolysaccharide treatment or type I IFN treatment alone does not cause caspase-11-dependent cell death
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poly(ADP-ribose) polymerase-1, PARP-1, regulates the expression of caspase-11 following lipopolysaccharide stimulation. PARP-1 is recruited to the caspase-11 promoter region containing predicted nuclear factor (NF)-kappaB-binding sites, but PARP-1 enzymatic activity is not required for the caspase-11 upregulation. PARP-1 can regulate the induction of caspase-11 at a transcriptional level. PARP-1 participates in the activation of caspase-11 promoter as a coactivator of NF-kappaB
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type I IFN signaling is sufficient to induce caspase-11 upregulation and processing. The adaptor protein TRIF upregulates procaspase-11 expression, and this upregulation is required for caspase-11 processing and activation
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cytosolic infection of cells with Burkholderia species and cytyosolic mutants of Salmonella typhimurium and Legionella pneumophila trigger the enzyme
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cytosolic infection of cells with Burkholderia species and cytyosolic mutants of Salmonella typhimurium and Legionella pneumophila trigger the enzyme
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