3.4.22.64: caspase-11
This is an abbreviated version!
For detailed information about caspase-11, go to the full flat file.
Word Map on EC 3.4.22.64
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3.4.22.64
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inflammasome
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pyroptosis
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lps
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lipopolysaccharide
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non-canonical
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gasdermin
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sepsis
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gsdmd
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interleukin-1
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lps-induced
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pyrin
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casp11
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apoptosis-associated
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nod-like
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caspase-5
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pore-forming
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speck-like
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guanylate-binding
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inflammasome-mediated
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wedelolactone
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rodentium
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pyroptosis-related
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inflammasome-dependent
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caspase-1/11
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caspase-1-mediated
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bmdms
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speck
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thailandensis
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medicine
- 3.4.22.64
- inflammasome
-
pyroptosis
- lps
- lipopolysaccharide
-
non-canonical
-
gasdermin
- sepsis
-
gsdmd
- interleukin-1
-
lps-induced
- pyrin
-
casp11
-
apoptosis-associated
-
nod-like
- caspase-5
-
pore-forming
-
speck-like
-
guanylate-binding
-
inflammasome-mediated
- wedelolactone
- rodentium
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pyroptosis-related
-
inflammasome-dependent
-
caspase-1/11
-
caspase-1-mediated
-
bmdms
-
speck
- thailandensis
- medicine
Reaction
strict requirement for Asp at the P1 position and has a preferred cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp-/- =
Synonyms
C14.012, CASP4, caspase 11, caspase-11, caspase-4, Ich-3, ICH-3 protease
ECTree
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Activating Compound
Activating Compound on EC 3.4.22.64 - caspase-11
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activation through dimerization. Signaling pathways involved in caspase-11 activation, overview
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additional information
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benzene, increase of caspase-4 expression after 12 days of oral benzene treatment to p53KO mice
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additional information
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activation through dimerization. Signaling pathways involved in caspase-11 activation, overview
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additional information
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Bacterial infection triggers caspase-11 activation , and intracellular lipopolysaccharide triggers caspase-11 activation, Toll-like receptor 4 is dispensable for caspase-11 triggering by cytoplasmic lipopolysaccharide, mechanism, detailed overview
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additional information
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caspase-11 is activated by a cytosolic sensing mechanism that detects bacterial-derived signals delivered into the host cytosol through the type IV secretion apparatus. Caspase-11 activation by Legionella pneumophila has distinct kinetic and molecular parameters, overview. Caspase-11 activation requires upstream protein(s) capable of sensing a microbial or endogenous danger signal. Caspase-11 requires type I IFN production mediated by TRIF-dependent TLR signaling. And caspase-1 is dispensable for caspase-11-dependent pyroptosis induced by Legionella pneumophila
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additional information
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the adaptor protein TRIF upregulates procaspase-11 expression, and this upregulation is required for caspase-11 processing and activation. Lipopolysaccharide treatment or type I IFN treatment alone does not cause caspase-11-dependent cell death
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additional information
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the cholera toxin B subunit and many different Gram-negative bacteria can trigger Caspase-11 activation in vitro. Cytosolic infection of cells with Burkholderia species and cytyosolic mutants of Salmonella typhimurium and Legionella pneumophila trigger the enzyme
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