3.4.22.62: caspase-9
This is an abbreviated version!
For detailed information about caspase-9, go to the full flat file.
Word Map on EC 3.4.22.62
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3.4.22.62
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caspase-3
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bcl-2
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parp
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anti-apoptotic
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pro-apoptotic
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tunel
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necrosis
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apoptosis-related
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caspase-dependent
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apoptosis-inducing
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jnk
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apaf-1
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annexin
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extrinsic
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cyclin
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leukemia
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bid
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neuroprotective
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depolarization
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polyadp-ribose
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survivin
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hoechst
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z-vad-fmk
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antiproliferative
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adp-ribose
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xiap
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iodide
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deoxynucleotidyl
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mitochondria-dependent
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mitochondria-mediated
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cisplatin
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dutp
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fadd
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procaspase-3
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caspase-mediated
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pan-caspase
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fas-mediated
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trail
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fas-associated
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trail-induced
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bcl-2-associated
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apoptogenic
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pharmacology
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cdc25c
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puma
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transferase-mediated
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executioner
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factor-related
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deltapsim
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medicine
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tunel-positive
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sub-g1
- 3.4.22.62
- caspase-3
- bcl-2
- parp
-
anti-apoptotic
-
pro-apoptotic
-
tunel
- necrosis
-
apoptosis-related
-
caspase-dependent
-
apoptosis-inducing
- jnk
- apaf-1
-
annexin
-
extrinsic
- cyclin
- leukemia
- bid
-
neuroprotective
-
depolarization
-
polyadp-ribose
- survivin
-
hoechst
- z-vad-fmk
-
antiproliferative
- adp-ribose
- xiap
- iodide
-
deoxynucleotidyl
-
mitochondria-dependent
-
mitochondria-mediated
- cisplatin
- dutp
- fadd
- procaspase-3
-
caspase-mediated
-
pan-caspase
-
fas-mediated
-
trail
-
fas-associated
-
trail-induced
-
bcl-2-associated
-
apoptogenic
- pharmacology
- cdc25c
- puma
-
transferase-mediated
-
executioner
-
factor-related
-
deltapsim
- medicine
-
tunel-positive
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sub-g1
Reaction
strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp-/-Xaa =
Synonyms
APAF, Apaf-3, apoptotic protease activating factor 3, apoptotic protease Mch-6, C14.010, CASP-9, casp9, casp9-gamma, caspase 9, caspase-9, ICE-LAP6, ICE-like apoptotic protease 6, Mch6
ECTree
3.4.22.62 caspase-9Advanced search results
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results (Application
Application on EC 3.4.22.62 - caspase-9
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
medicine
pharmacology
medicine
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inhibition of the caspase-9 activity would render opportunity to treat patients suffering from neurological diseases such as stroke, neurodegenerative diseases or brain injury caused by hypoxia
medicine
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caspase-9 is a target for development of therapeutic approaches for histamine-related diseases
medicine
analysis of a single nucleotide polymorphism (SNP) in the caspase-9 gene in relation to susceptibility to multiple sclerosis (MS)
medicine
dysregulation of the apoptotic response in differentiating neurons participates in the neuropathology of diseases that display with an imbalance of DYRK1A gene-dosage
medicine
effectiveness and specificity of an inducible caspase 9-based safety switch system, to halt an ongoing immune attack, reduction of the risk of severe graft-vs-host disease, murine model for cell therapy-induced type I diabetes
medicine
mechanisms of adenosine-induced apoptosis in human colonic cancer cells
medicine
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there is a weak correlation between activated caspase-9 and poor neurologic outcome after severe traumatic brain injury
medicine
B cell lymphoid malignancies are treated with T cells expressing the chimeric antigen receptor (CAR) specific for the CD19 antigen (CD19.CAR-Ts). The inducible caspase-9 safety switch, i.e. a modified human caspase-9 fused to the human FK506 binding protein, can eliminate CD19.CAR-Ts in a dose-dependent manner, allowing either a selective containment of CD19.CAR-T expansion in case of cytokine release syndrome or complete deletion on demand granting normal B cell reconstitution
medicine
levels of caspase-8 and caspase-9 in sperm and plasma are significantly negatively correlated with sperm concentration, motility and A % (motility grade A). Only in healthy fertile controls sperm concentration is significantly negatively correlated with caspase-9 in sperm. Caspase-8 and caspase-9 in sperm and plasma are correlated with sperm motility, and can reflect the quality of sperm in vitro
medicine
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caspase-9 is a target for development of therapeutic approaches for histamine-related diseases
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pharmacology
drug development, studies on mechanisms of apoptosis activated in response to marine sponge extracts of Polymastia janeirensis
pharmacology
in vitro analysis of apoptotic mechanism of isorhamnetin in Lewis lung cancer (LLC) cells, in vivo anti-cancer efficacy
pharmacology
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NaF-induced apoptosis of osteoblasts, in vitro studies, pronounced negative effect of NaF treatment on indices of survival of osteoblasts, decreased proliferation, increased apoptosis and increased caspase-3 and caspase-9 mRNA
pharmacology
rituximab-induced apoptosis highly dependent on caspase-9 activation, regulated by Bcl-xL expression
pharmacology
studies on mechanisms of apoptosis induced by high linear energy transfer (LET) radiation
pharmacology
studies on mechanisms of apoptosis induced by ionizing radiation in human leukaemic cells with a different status of p53 (TP53 tumor suppressor gene)
pharmacology
studies on molecular mechanisms of caspase-9 activation mediated by reactive oxygen species (ROS)
pharmacology
studies on the mechanism of cordycepin-induced apoptosis in MA-10 Leydig tumor cells
pharmacology
the cellular-FLICE inhibitory protein (c-FLIP) analyzed as a potential therapeutic target for breast cancers
pharmacology
therapeutic usefulness of the herbal drug Hwanggunchungyitang (HGCYT) against cadmium (Cd2+)-induced activation of caspase-9
