3.4.22.54: calpain-3

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For detailed information about calpain-3, go to the full flat file.

Reaction

broad endopeptidase activity =

Synonyms

C3DIV, calcium-activated neutral proteinase 3, Calp3, calpain 3, calpain 3 (p94), calpain 3 domain IV, calpain 3/p94, calpain L3, calpain M, calpain p94, calpain-3, calpain3, CANP 3, CAPN3, Cn94, MP78, Mp84, muscle calpain, muscle-specific calcium-activated neutral protease 3, muscle-specific calpain, nCL-1, p94, p94-calpain, p94/calpain 3, skeletal muscle-specific calpain

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.54 calpain-3

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Results	in table
4	Activating Compound
2077	AA Sequence
2	CAS Registry Number
18	Cloned(Commentary)
2	Crystallization (Commentary)
978	Disease/ Diagnostics
4	Expression
21	General Information
10	General Stability
4	IC50 Value
12	Inhibitors
23	Localization
31	Metals/Ions
13	Molecular Weight [Da]
46	Natural Substrates/ Products (Substrates)
94	Organism
19	PDB ID
1	pH Optimum
1	pI Value
3	Posttranslational Modification
50	Protein Variants
7	Purification (Commentary)
2	Reaction
2	Reaction Type
93	Reference
106	Source Tissue
100	Substrates and Products (Substrate)
9	Subunits
91	Synonyms

Crystallization

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Crystallization on EC 3.4.22.54 - calpain-3

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

hanging-drop vapor diffusion method at 22°C, structures of calpain-3 Protease core mutant-C129S, calpain-3 protease core in complex with E-64, calpain-3 protease core in complex with leupeptin

Homo sapiens

P20807

754170

model of calpain 3 by crystal structures of human calpain2 and calpastatin-inhibited rat calpain2

Homo sapiens

-

696327