3.4.22.49: separase
This is an abbreviated version!
For detailed information about separase, go to the full flat file.
Word Map on EC 3.4.22.49
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3.4.22.49
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chromatid
-
sister
-
anaphase
-
cohesin
-
mitosis
-
securin
-
spindle
-
metaphase
-
meiotic
-
checkpoint
-
centromeres
-
kinetochore
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anaphase-promoting
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scc1
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prophase
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aneuploidy
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rec8
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cdc14
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rad21
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metaphase-to-anaphase
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centrosome
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shugoshins
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centriole
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sister-chromatid
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metaphase-anaphase
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disjunction
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medicaid
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disengagement
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prometaphase
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missegregation
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polo-like
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biorientation
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cyclosome
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kleisin
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meiosis-specific
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chiasmata
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pds1
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condensins
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medicine
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diagnostics
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nondisjunction
-
molecular biology
-
cdk1-dependent
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pp2acdc55
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kinetochore-microtubule
- 3.4.22.49
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chromatid
-
sister
-
anaphase
- cohesin
-
mitosis
- securin
- spindle
-
metaphase
-
meiotic
-
checkpoint
-
centromeres
-
kinetochore
-
anaphase-promoting
- scc1
-
prophase
-
aneuploidy
- rec8
- cdc14
- rad21
-
metaphase-to-anaphase
- centrosome
- shugoshins
- centriole
-
sister-chromatid
-
metaphase-anaphase
-
disjunction
-
medicaid
-
disengagement
-
prometaphase
-
missegregation
-
polo-like
-
biorientation
-
cyclosome
-
kleisin
-
meiosis-specific
-
chiasmata
- pds1
-
condensins
- medicine
- diagnostics
-
nondisjunction
- molecular biology
-
cdk1-dependent
-
pp2acdc55
-
kinetochore-microtubule
Reaction
all bonds known to be hydrolysed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by an hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage =
Synonyms
AESP, AtESP, Cut1, Cut1/separase, ESP, Esp1, ESPL1, sep-1, separase, separin, SSE, TbSep
ECTree
3.4.22.49 separaseAdvanced search results
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Reference on EC 3.4.22.49 - separase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yanagida, M.
Cell cycle mechanisms of sister chromatid separation; roles of Cut1/separin and Cut2/securin
Genes Cells
5
1-8
2000
Saccharomyces cerevisiae, Homo sapiens, Schizosaccharomyces pombe
Sullivan, M.; Lehane, C.; Uhlmann, F.
Orchestrating anaphase and mitotic exit: separase cleavage and localization of Slk19
Nat. Cell Biol.
3
771-777
2001
Saccharomyces cerevisiae
Amon, A.
Together until separin do us part
Nat. Cell Biol.
3
E12-14
2001
Saccharomyces cerevisiae, Homo sapiens, Schizosaccharomyces pombe
Siomos, M.F.; Badrinath, A.; Pasierbek, P.; Livingstone, D.; White, J.; Glotzer, M.; Nasmyth, K.
Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans
Curr. Biol.
11
1825-1835
2001
Saccharomyces cerevisiae, Caenorhabditis elegans
Jager, H.; Herzig, A.; Lehner, C.F.; Heidmann, S.
Drosophila separase is required for sister chromatid separation and binds to PIM and THR
Genes Dev.
15
2572-2584
2001
Drosophila melanogaster
Hauf, S.; Waizenegger, I.C.; Peters, J.M.
Cohesin cleavage by separase required for anaphase and cytokinesis in human cells
Science
293
1320-1323
2001
Homo sapiens
Ross, K.E.; Cohen-Fix, O.
Separase: a conserved protease separating more than just sisters
Trends Cell Biol.
12
1-3
2002
Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, Schizosaccharomyces pombe, Xenopus laevis
Zou, H.; Stemman, O.; Anderson, J.S.; Mann, M.; Kirschner, M.W.
Anaphase specific auto-cleavage of separase
FEBS Lett.
528
246-250
2002
Homo sapiens
Hornig, N.C.; Knowles, P.P.; McDonald, N.Q.; Uhlmann, F.
The dual mechanism of separase regulation by securin
Curr. Biol.
12
973-982
2002
Saccharomyces cerevisiae
Waizenegger, I.C.; Gimenez-Abian, J.F.; Wernic, D.; Peters, J.M.
Regulation of human separase by securin binding and autocleavage
Curr. Biol.
12
1368-1378
2002
Homo sapiens
Stegmeier, F.; Visintin, R.; Amon, A.
Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase
Cell
108
207-220
2002
Saccharomyces cerevisiae
Buonomo, S.B.C.; Rabitsch, K.P.; Fuchs, J.; Gruber, S.; Sullivan, M.; Uhlmann, F.; Petronczki, M.; Toth, A.; Nasmyth, K.
Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19
Dev. Cell
4
727-739
2003
Saccharomyces cerevisiae
Sullivan, M.; Uhlmann, F.
A non-proteolytic function of separase links the onset of anaphase to mitotic exit
Nat. Cell Biol.
5
249-254
2003
Saccharomyces cerevisiae
Chestukhin, A.; Pfeffer, C.; Milligan, S.; DeCaprio, J.A.; Pellman, D.
Processing, localization, and requirement of human separase for normal anaphase progression
Proc. Natl. Acad. Sci. USA
100
4574-4579
2003
Homo sapiens
Queralt, E.; Lehane, C.; Novak, B.; Uhlmann, F.
Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast
Cell
125
719-732
2006
Saccharomyces cerevisiae
Kudo, N.R.; Wassmann, K.; Anger, M.; Schuh, M.; Wirth, K.G.; Xu, H.; Helmhart, W.; Kudo, H.; McKay, M.; Maro, B.; Ellenberg, J.; de Boer, P.; Nasmyth, K.
Resolution of chiasmata in oocytes requires separase-mediated proteolysis
Cell
126
135-146
2006
Mus musculus (P60330), Mus musculus
Gimenez-Abian, J.F.; Diaz-Martinez, L.A.; Waizenegger, I.C.; Gimenez-Martin, G.; Clarke, D.J.
Separase is required at multiple pre-anaphase cell cycle stages in human cells
Cell Cycle
4
1576-1584
2005
Homo sapiens
Kawasaki, Y.; Nagao, K.; Nakamura, T.; Yanagida, M.
Fission yeast MAP kinase is required for the increased securin-separase interaction that rescues separase mutants under stresses
Cell Cycle
5
1831-1839
2006
Schizosaccharomyces pombe
Fan, H.Y.; Sun, Q.Y.; Zou, H.
Regulation of Separase in meiosis: Separase is activated at the metaphase I-II transition in Xenopus oocytes during meiosis
Cell Cycle
5
198-204
2006
Xenopus sp.
Terret, M.E.; Wassmann, K.; Waizenegger, I.; Maro, B.; Peters, J.M.; Verlhac, M.H.
The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity
Curr. Biol.
13
1797-1802
2003
Mus musculus
Kitajima, T.S.; Miyazaki, Y.; Yamamoto, M.; Watanabe, Y.
Rec8 cleavage by separase is required for meiotic nuclear divisions in fission yeast
EMBO J.
22
5643-5653
2003
Schizosaccharomyces pombe
Nagao, K.; Yanagida, M.
Securin can have a separase cleavage site by substitution mutations in the domain required for stabilization and inhibition of separase
Genes Cells
11
247-260
2006
Schizosaccharomyces pombe
Sullivan, M.; Hornig, N.C.; Porstmann, T.; Uhlmann, F.
Studies on substrate recognition by the budding yeast separase
J. Biol. Chem.
279
1191-1196
2004
Saccharomyces cerevisiae
Wirth, K.G.; Wutz, G.; Kudo, N.R.; Desdouets, C.; Zetterberg, A.; Taghybeeglu, S.; Seznec, J.; Ducos, G.M.; Ricci, R.; Firnberg, N.; Peters, J.M.; Nasmyth, K.
Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression
J. Cell Biol.
172
847-860
2006
Mus musculus
Pandey, R.; Heidmann, S.; Lehner, C.F.
Epithelial re-organization and dynamics of progression through mitosis in Drosophila separase complex mutants
J. Cell Sci.
118
733-742
2005
Drosophila sp. (in: flies)
Ikai, N.; Yanagida, M.
Cdc48 is required for the stability of Cut1/separase in mitotic anaphase
J. Struct. Biol.
156
50-61
2006
Schizosaccharomyces pombe
Gorr, I.H.; Boos, D.; Stemmann, O.
Mutual inhibition of separase and Cdk1 by two-step complex formation
Mol. Cell
19
135-141
2005
Xenopus sp.
Papi, M.; Berdougo, E.; Randall, C.L.; Ganguly, S.; Jallepalli, P.V.
Multiple roles for separase auto-cleavage during the G2/M transition
Nat. Cell Biol.
7
1029-1035
2005
Homo sapiens
Nagao, K.; Adachi, Y.; Yanagida, M.
Separase-mediated cleavage of cohesin at interphase is required for DNA repair
Nature
430
1044-1048
2004
Schizosaccharomyces pombe
Liu, Z.; Makaroff, C.A.
Arabidopsis separase AESP is essential for embryo development and the release of cohesin during meiosis
Plant Cell
18
1213-1225
2006
Arabidopsis thaliana (Q5IBC5), Arabidopsis thaliana
Pereira, G.; Schiebel, E.
Separase regulates INCENP-Aurora B anaphase spindle function through Cdc14
Science
302
2120-2124
2003
Saccharomyces cerevisiae
Bembenek, J.N.; Richie, C.T.; Squirrell, J.M.; Campbell, J.M.; Eliceiri, K.W.; Poteryaev, D.; Spang, A.; Golden, A.; White, J.G.
Cortical granule exocytosis in C. elegans is regulated by cell cycle components including separase
Development
134
3837-3848
2007
Caenorhabditis elegans
Shepard, J.L.; Amatruda, J.F.; Finkelstein, D.; Ziai, J.; Finley, K.R.; Stern, H.M.; Chiang, K.; Hersey, C.; Barut, B.; Freeman, J.L.; Lee, C.; Glickman, J.N.; Kutok, J.L.; Aster, J.C.; Zon, L.I.
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer
Genes Dev.
21
55-59
2007
Danio rerio
Boos, D.; Kuffer, C.; Lenobel, R.; Koerner, R.; Stemmann, O.
Phosphorylation-dependent binding of cyclin B1 to a Cdc6-like domain of human separase
J. Biol. Chem.
283
816-823
2008
Homo sapiens
Nakajima, M.; Kumada, K.; Hatakeyama, K.; Noda, T.; Peters, J.M.; Hirota, T.
The complete removal of cohesin from chromosome arms depends on separase
J. Cell Sci.
120
4188-4196
2007
Homo sapiens
Pemberton, H.N.; Franklyn, J.A.; Boelaert, K.; Chan, S.Y.; Kim, D.S.; Kim, C.; Cheng, S.Y.; Kilby, M.D.; McCabe, C.J.
Separase, securin and Rad21 in neural cell growth
J. Cell. Physiol.
213
45-53
2007
Homo sapiens, Mus musculus
Gorr, I.H.; Reis, A.; Boos, D.; Wuehr, M.; Madgwick, S.; Jones, K.T.; Stemmann, O.
Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes
Nat. Cell Biol.
8
1035-1037
2006
Xenopus laevis
Terret, M.; Jallepalli, P.V.
Meiosis: separase strikes twice
Nat. Cell Biol.
8
910-911
2006
Saccharomyces cerevisiae, Mus musculus
Huang, X.; Andreu-Vieyra, C.V.; York, J.P.; Hatcher, R.; Lu, T.; Matzuk, M.M.; Zhang, P.
Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells
PLoS Biol.
6
e15
2008
Mus musculus
Adachi, Y.; Kokubu, A.; Ebe, M.; Nagao, K.; Yanagida, M.
Cut1/separase-dependent roles of multiple phosphorylation of fission yeast cohesion subunit Rad21 in post-replicative damage repair and mitosis
Cell Cycle
7
765-776
2008
Schizosaccharomyces pombe
Sak, A.; Fegers, I.; Groneberg, M.; Stuschke, M.
Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines
Cell Prolif.
41
660-670
2008
Homo sapiens
Sun, Y.; Kucej, M.; Fan, H.Y.; Yu, H.; Sun, Q.Y.; Zou, H.
Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner
Cell
137
123-132
2009
Homo sapiens
Meyer, R.; Fofanov, V.; Panigrahi, A.; Merchant, F.; Zhang, N.; Pati, D.
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers
Clin. Cancer Res.
15
2703-2710
2009
Homo sapiens
Clift, D.; Bizzari, F.; Marston, A.L.
Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase
Genes Dev.
23
766-780
2009
Anaplasma marginale
Baskerville, C.; Segal, M.; Reed, S.I.
The protease activity of yeast separase (esp1) is required for anaphase spindle elongation independently of its role in cleavage of cohesin
Genetics
178
2361-2372
2008
Saccharomyces cerevisiae
Queralt, E.; Uhlmann, F.
Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase
J. Cell Biol.
182
873-883
2008
Saccharomyces cerevisiae
Fujita, T.; Epperly, M.W.; Zou, H.; Greenberger, J.S.; Wan, Y.
Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells
Mol. Biol. Cell
19
5446-5455
2008
Mus musculus
Lu, Y.; Cross, F.
Mitotic exit in the absence of separase activity
Mol. Biol. Cell
20
1576-1591
2009
Saccharomyces cerevisiae (Q03018), Saccharomyces cerevisiae
Huang, X.; Andreu-Vieyra, C.V.; Wang, M.; Cooney, A.J.; Matzuk, M.M.; Zhang, P.
Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation
Mol. Cell. Biol.
29
1498-1505
2009
Mus musculus
Bessat, M.; Ersfeld, K.
Functional characterization of cohesin SMC3 and separase and their roles in the segregation of large and minichromosomes in Trypanosoma brucei
Mol. Microbiol.
71
1371-1385
2009
Trypanosoma brucei
Zhang, N.; Ge, G.; Meyer, R.; Sethi, S.; Basu, D.; Pradhan, S.; Zhao, Y.J.; Li, X.N.; Cai, W.W.; El-Naggar, A.K.; Baladandayuthapani, V.; Kittrell, F.S.; Rao, P.H.; Medina, D.; Pati, D.
Overexpression of Separase induces aneuploidy and mammary tumorigenesis
Proc. Natl. Acad. Sci. USA
105
13033-13038
2008
Homo sapiens, Mus musculus
Basu, D.; Zhang, N.; Panigrahi, A.K.; Horton, T.M.; Pati, D.
Development and validation of a fluorogenic assay to measure separase enzyme activity
Anal. Biochem.
392
133-138
2009
Homo sapiens
Bembenek, J.N.; White, J.G.; Zheng, Y.
A role for separase in the regulation of RAB-11-positive vesicles at the cleavage furrow and midbody
Curr. Biol.
20
259-264
2010
Caenorhabditis elegans
Tsou, M.F.; Wang, W.J.; George, K.A.; Uryu, K.; Stearns, T.; Jallepalli, P.V.
Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells
Dev. Cell
17
344-354
2009
Homo sapiens
Katis, V.L.; Lipp, J.J.; Imre, R.; Bogdanova, A.; Okaz, E.; Habermann, B.; Mechtler, K.; Nasmyth, K.; Zachariae, W.
Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis
Dev. Cell
18
397-409
2010
Saccharomyces cerevisiae, Saccharomyces cerevisiae SK1
Wu, S.; Scheible, W.R.; Schindelasch, D.; Van Den Daele, H.; De Veylder, L.; Baskin, T.I.
A conditional mutation in Arabidopsis thaliana separase induces chromosome non-disjunction, aberrant morphogenesis and cyclin B1,1 stability
Development
137
953-961
2010
Arabidopsis thaliana
Nakamura, A.; Arai, H.; Fujita, N.
Centrosomal Aki1 and cohesin function in separase-regulated centriole disengagement
J. Cell Biol.
187
607-614
2009
Homo sapiens
Kudo, N.R.; Anger, M.; Peters, A.H.; Stemmann, O.; Theussl, H.C.; Helmhart, W.; Kudo, H.; Heyting, C.; Nasmyth, K.
Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I
J. Cell Sci.
122
2686-2698
2009
Homo sapiens
Ishiguro, T.; Tanaka, K.; Sakuno, T.; Watanabe, Y.
Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase
Nat. Cell Biol.
12
500-506
2010
Homo sapiens
Yang, X.; Boateng, K.A.; Strittmatter, L.; Burgess, R.; Makaroff, C.A.
Arabidopsis separase functions beyond the removal of sister chromatid cohesion during meiosis
Plant Physiol.
151
323-333
2009
Arabidopsis thaliana
Vinod, P.K.; Freire, P.; Rattani, A.; Ciliberto, A.; Uhlmann, F.; Novak, B.
Computational modelling of mitotic exit in budding yeast: the role of separase and Cdc14 endocycles
J. R. Soc. Interface
8
1128-1141
2011
Saccharomyces cerevisiae
Kucej, M.; Zou, H.
DNA-dependent cohesin cleavage by separase
Nucleus
1
4-7
2011
Saccharomyces cerevisiae, Homo sapiens, Mus musculus
Moschou, P.N.; Bozhkov, P.V.
Separases: biochemistry and function
Physiol. Plant.
145
67-76
2012
Saccharomyces cerevisiae, Caenorhabditis elegans, Ricinus communis, Chlamydomonas reinhardtii, Drosophila melanogaster, Homo sapiens, Oryza sativa, Schizosaccharomyces pombe, Sorghum bicolor, Vitis vinifera, Cryptosporidium muris, Arabidopsis thaliana (Q5IBC5)
Yim, H.; Erikson, R.L.
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase
Proc. Natl. Acad. Sci. USA
107
19742-19747
2010
Homo sapiens
Bacac, M.; Fusco, C.; Planche, A.; Santodomingo, J.; Demaurex, N.; Leemann-Zakaryan, R.; Provero, P.; Stamenkovic, I.
Securin and separase modulate membrane traffic by affecting endosomal acidification
Traffic
12
615-626
2011
Homo sapiens
Matsuo, K.; Ohsumi, K.; Iwabuchi, M.; Kawamata, T.; Ono, Y.; Takahashi, M.
Kendrin is a novel substrate for separase involved in the licensing of centriole duplication
Curr. Biol.
22
915-921
2012
Homo sapiens (Q14674)
Shindo, N.; Kumada, K.; Hirota, T.
Separase sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition
Dev. Cell
23
112-123
2012
Mus musculus (P60330)
Yaakov, G.; Thorn, K.; Morgan, D.O.
Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation
Dev. Cell
23
124-136
2012
Saccharomyces cerevisiae (Q03018), Saccharomyces cerevisiae
Hellmuth, S.; Poehlmann, C.; Brown, A.; Boettger, F.; Sprinzl, M.; Stemmann, O.
Positive and negative regulation of vertebrate separase by cdk1-cyclin b1 may explain why securin is dispensable
J. Biol. Chem.
290
8002-8010
2015
Homo sapiens (Q14674)
Han, X.; Poon, R.Y.
Critical differences between isoforms of securin reveal mechanisms of separase regulation
Mol. Cell. Biol.
33
3400-3415
2013
Saccharomyces cerevisiae (Q03018)
Agircan, F.G.; Schiebel, E.
Sensors at centrosomes reveal determinants of local separase activity
PLoS Genet.
10
e1004672
2014
Homo sapiens (Q14674)
Ho, K.L.; Ma, L.; Cheung, S.; Manhas, S.; Fang, N.; Wang, K.; Young, B.; Loewen, C.; Mayor, T.; Measday, V.
A role for the budding yeast separase, Esp1, in Ty1 element retrotransposition
PLoS Genet.
11
e1005109
2015
Saccharomyces cerevisiae (Q03018), Saccharomyces cerevisiae
Haass, W.; Stehle, M.; Nittka, S.; Giehl, M.; Schrotz-King, P.; Fabarius, A.; Hofmann, W.K.; Seifarth, W.
The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib
PLoS ONE
7
e42863
2012
Homo sapiens (Q14674), Homo sapiens
Zhang, N.; Pati, D.
Biology and insights into the role of cohesin protease separase in human malignancies
Biol. Rev. Camb. Philos. Soc.
92
2070-2083
2017
Mus musculus (P60330), Mus musculus, Homo sapiens (Q14674), Homo sapiens
Do, H.T.; Zhang, N.; Pati, D.; Gilbertson, S.R.
Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase
Bioorg. Med. Chem. Lett.
26
4446-4450
2016
Homo sapiens (Q14674), Homo sapiens
Luo, S.; Tong, L.
Structural biology of the separase-securin complex with crucial roles in chromosome segregation
Curr. Opin. Struct. Biol.
49
114-122
2018
Saccharomyces cerevisiae, Thermochaetoides thermophila (G0SHM3), Caenorhabditis elegans (G5ED39), Caenorhabditis elegans, Thermochaetoides thermophila DSM 1495 (G0SHM3)
Kumar, R.
Separase Function beyond cohesion cleavage and an emerging oncogene
J. Cell. Biochem.
118
1283-1299
2017
Caenorhabditis elegans, Arabidopsis thaliana (A0A1P8B3N4), Schizosaccharomyces pombe (P18296), Saccharomyces cerevisiae (Q03018), Drosophila melanogaster (Q9VRN6), Picea abies (R4XPW1), Schizosaccharomyces pombe ATCC 24843 (P18296)
Cipressa, F.; Morciano, P.; Bosso, G.; Mannini, L.; Galati, A.; Raffa, G.D.; Cacchione, S.; Musio, A.; Cenci, G.
A role for Separase in telomere protection
Nat. Commun.
7
10405
2016
Drosophila sp. (in: flies)
Lin, Z.; Luo, X.; Yu, H.
Structural basis of cohesin cleavage by separase
Nature
532
131-134
2016
Thermochaetoides thermophila (G0SHM3), Thermochaetoides thermophila DSM 1495 (G0SHM3)
Winter, A.; Schmid, R.; Bayliss, R.
Structural insights into separase architecture and substrate recognition through computational modelling of caspase-like and death domains
PLoS Comput. Biol.
11
e1004548
2015
Caenorhabditis elegans (G5ED39), Caenorhabditis elegans, Saccharomyces cerevisiae (Q03018), Homo sapiens (Q14674), Arabidopsis thaliana (Q5IBC5), Saccharomyces cerevisiae ATCC 204508 (Q03018)
Blattner, A.C.; Chaurasia, S.; McKee, B.D.; Lehner, C.F.
Separase is required for homolog and sister disjunction during Drosophila melanogaster male meiosis, but not for biorientation of sister centromeres
PLoS Genet.
12
e1005996
2016
Drosophila melanogaster (Q9VRN6), Drosophila melanogaster
Monen, J.; Hattersley, N.; Muroyama, A.; Stevens, D.; Oegema, K.; Desai, A.
Separase cleaves the N-tail of the CENP-A related protein CPAR-1 at the meiosis I metaphase-anaphase transition in C. elegans
PLoS ONE
10
e0125382
2015
Caenorhabditis elegans (G5ED39), Caenorhabditis elegans
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