3.4.22.46: L-peptidase

This is an abbreviated version!
For detailed information about L-peptidase, go to the full flat file.

Reaction

autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-/-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-/-Arg- and -Lys-/-Arg- =

Synonyms

3C protease, 3Cpro, Eukaryotic signal peptidase, Eukaryotic signal proteinase, FMDV 3Cpro, foot-and-mouth disease virus 3C protease, L protein, L proteinase, Lab protein, Lb proC, Lbpro, Leader peptidase, leader peptidase B, leader peptidase NisP, Leader peptide hydrolase, leader protease, Leader proteinase, leaderprotease L1, leaderprotease L2, LepB, Lpro, nisin leader peptidase, NisP, nsp1alpha, P1a protein, Peptidase, signal, Prokaryotic leader peptidase, Prokaryotic signal peptidase, Prokaryotic signal proteinase, Propeptidase, Proteinase, eukaryotic signal, Proteinase, signal, Signal peptidase, Signalase, sLbpro

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.46 L-peptidase

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Results	in table
15	AA Sequence
1	Application
1	CAS Registry Number
18	Cloned(Commentary)
4	Crystallization (Commentary)
11	General Information
11	Inhibitors
6	Ki Value [mM]
1	KM Value [mM]
2	Localization
11	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
40	Organism
26	PDB ID
4	pH Optimum
1	pH Range
2	Posttranslational Modification
26	Protein Variants
8	Purification (Commentary)
1	Reaction
1	Reaction Type
33	Reference
1	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
62	Substrates and Products (Substrate)
9	Subunits
67	Synonyms
3	Temperature Optimum [°C]

Synonyms

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Synonyms on EC 3.4.22.46 - L-peptidase

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3C protease

Foot-and-mouth disease virus

-

-

669685

3Cpro

Foot-and-mouth disease virus

-

-

669685

Eukaryotic signal peptidase

-

-

-

-

Eukaryotic signal proteinase

-

-

-

-

FMDV 3Cpro

Foot-and-mouth disease virus

-

-

709535

foot-and-mouth disease virus 3C protease

Foot-and-mouth disease virus

-

-

709535

L protein

Foot-and-mouth disease virus

-

-

718451

L proteinase

2 entries

Lab protein

Foot-and-mouth disease virus

-

-

718451

Lb proC

Foot-and-mouth disease virus

-

-

681455

Lbpro

2 entries

Leader peptidase

-

-

-

-

leader peptidase B

2 entries

leader peptidase NisP

Lactococcus lactis subsp. lactis

Q07596

-

752774

Leader peptide hydrolase

-

-

-

-

leader protease

2 entries

Leader proteinase

5 entries

leaderprotease L1

Citrus tristeza virus

-

-

755647

leaderprotease L2

Citrus tristeza virus

-

-

755647

LepB

2 entries

Lpro

4 entries

nisin leader peptidase

Lactococcus lactis

D9IXC0

-

731065

NisP

Lactococcus lactis

D9IXC0

-

731065

nsp1alpha

porcine reproductive and respiratory syndrome virus

-

-

732973

P1a protein

cucumber vein yellowing virus

Q1G2C1

-

732976

Peptidase, signal

-

-

-

-

Prokaryotic leader peptidase

-

-

-

-

Prokaryotic signal peptidase

-

-

-

-

Prokaryotic signal proteinase

-

-

-

-

Propeptidase

-

-

-

-

Proteinase, eukaryotic signal

-

-

-

-

Proteinase, signal

-

-

-

-

Signal peptidase

-

-

-

-

Signalase

-

-

-

-

sLbpro

Foot-and-mouth disease virus

P03305

during infection, isoform Lbpro removes six residues from its own C-terminus, generating sLbpro

732975

L proteinase

-

-

-

-

L proteinase

Foot-and-mouth disease virus

-

-

718451

Lbpro

Foot-and-mouth disease virus

-

-

681680, 717297, 732973

Lbpro

Foot-and-mouth disease virus

P03305

isoform

732975

leader peptidase B

Mycobacterium tuberculosis

P9WKA1

-

731252

leader peptidase B

Mycobacterium tuberculosis H37Rv

P9WKA1

-

-

leader protease

cucumber vein yellowing virus

Q1G2C1

-

732976

leader protease

Foot-and-mouth disease virus

-

-

669685, 681455, 717297, 755214

Leader proteinase

-

-

-

-

Leader proteinase

Foot-and-mouth disease virus

-

-

667582, 668547, 670093, 681680, 717188, 718451, 731405, 732973

Leader proteinase

Foot-and-mouth disease virus

P03305

-

681697, 732975

Leader proteinase

Foot-and-mouth disease virus FMDV

-

-

-

Leader proteinase

porcine reproductive and respiratory syndrome virus

-

-

732973

LepB

Mycobacterium tuberculosis

P9WKA1

-

731252

LepB

Mycobacterium tuberculosis H37Rv

P9WKA1

-

-

Lpro

-

-

-

-

Lpro

Foot-and-mouth disease virus

-

-

667582, 668547, 669685, 670093, 717188, 731405, 755214

Lpro

Foot-and-mouth disease virus

P03305

-

681697, 732975

Lpro

Foot-and-mouth disease virus FMDV

-

-

-