Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.22.46: L-peptidase

This is an abbreviated version!
For detailed information about L-peptidase, go to the full flat file.

Word Map on EC 3.4.22.46

Reaction

autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-/-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-/-Arg- and -Lys-/-Arg- =

Synonyms

3C protease, 3Cpro, Eukaryotic signal peptidase, Eukaryotic signal proteinase, FMDV 3Cpro, foot-and-mouth disease virus 3C protease, L protein, L proteinase, Lab protein, Lb proC, Lbpro, Leader peptidase, leader peptidase B, leader peptidase NisP, Leader peptide hydrolase, leader protease, Leader proteinase, leaderprotease L1, leaderprotease L2, LepB, Lpro, nisin leader peptidase, NisP, nsp1alpha, P1a protein, Peptidase, signal, Prokaryotic leader peptidase, Prokaryotic signal peptidase, Prokaryotic signal proteinase, Propeptidase, Proteinase, eukaryotic signal, Proteinase, signal, Signal peptidase, Signalase, sLbpro

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.46 L-peptidase

Reference

Reference on EC 3.4.22.46 - L-peptidase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kirchweger, R.; Ziegler, E.; Lamphear, B.J.; Waters, D.; Liebig, H.D.; Sommergruber, W.; Sobrino, F.; Hohenadl, C.; Blaas, D.; Rhoads, R.E.; Skern, T.
Foot-and-mouth disease virus leader proteinase: purification of the Lb form and determination of its cleavage site on eIF-4gamma
J. Virol.
68
5677-5684
1994
Foot-and-mouth disease virus
Manually annotated by BRENDA team
Piccone, M.E.; Zellner, M.; Kumosinski, T.F.; Mason, P.W.; Grubman, M.J.
Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus
J. Virol.
69
4950-4956
1995
Foot-and-mouth disease virus
Manually annotated by BRENDA team
Guarne, A.; Hampoelz, B.; Glaser, W.; Carpena, X.; Torma, J.; Fita, I.; Skern, T.
Structural and biochemical features distinguish the foot-and-mouth disease virus leader proteinase from other papain-like enzymes
J. Mol. Biol.
302
1227-1240
2000
Foot-and-mouth disease virus
Manually annotated by BRENDA team
Glaser, W.; Skern, T.
Extremely efficient cleavage of eIF4G by picornaviral proteinases L and 2A in vitro
FEBS Lett.
480
151-155
2000
Foot-and-mouth disease virus
Manually annotated by BRENDA team
Guarne, A.; Tormo, J.; Kirchweger, R.; Pfistermueller, D.; Fita, I.; Skern, T.
Structure of the foot-and-mouth disease virus leader protease: a papain-like fold adapted for self-processing and eIF4G recognition
EMBO J.
17
7469-7479
1998
Foot-and-mouth disease virus
Manually annotated by BRENDA team
Piccone, M.E.; Sira, S.; Zellner, M.; Grubman, M.J.
Expression in Escherichia coli and purification of biologically active L proteinase of foot-and-mouth disease virus
Virus Res.
35
263-275
1995
Foot-and-mouth disease virus
Manually annotated by BRENDA team
Skern, T.; Fita, I.; Guarne, A.
A structural model of picornavirus leader proteinases based on papain and bleomycin hydrolase
J. Gen. Virol.
79
301-307
1998
Foot-and-mouth disease virus
Manually annotated by BRENDA team
Ziegler, E.; Borman, A.M.; Kirchweger, R.; Skern, T.; Kean, K.M.
Foot-and-mouth disease virus Lb proteinase can stimulate rhinovirus and enterovirus IRES-driven translation and cleave several proteins of cellular and viral origin
J. Virol.
69
3465-3474
1995
Foot-and-mouth disease virus
Manually annotated by BRENDA team
Kuehnel, E.; Cencic, R.; Foeger, N.; Skern, T.
Foot-and-mouth disease virus leader proteinase: specificity at the P2 and P3 positions and comparison with other papain-like enzymes
Biochemistry
43
11482-11490
2004
Foot-and-mouth disease virus, Foot-and-mouth disease virus FMDV
Manually annotated by BRENDA team
Foeger, N.; Kuehnel, E.; Cencic, R.; Skern, T.
The binding of foot-and-mouth disease virus leader proteinase to eIF4GI involves conserved ionic interactions
FEBS J.
272
2602-2611
2005
Foot-and-mouth disease virus, Foot-and-mouth disease virus FMDV
Manually annotated by BRENDA team
Strong, R.; Belsham, G.J.
Sequential modification of translation initiation factor eIF4GI by two different foot-and-mouth disease virus proteases within infected baby hamster kidney cells: Identification of the 3Cpro cleavage site
J. Gen. Virol.
85
3817
2004
Foot-and-mouth disease virus
-
Manually annotated by BRENDA team
de Los Santos, T.; de Avila Botton, S.; Weiblen, R.; Grubman, M.J.
The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response
J. Virol.
80
1906-1914
2006
Foot-and-mouth disease virus, Foot-and-mouth disease virus FMDV
Manually annotated by BRENDA team
Cencic, R.; Mayer, C.; Juliano, M.A.; Juliano, L.; Konrat, R.; Kontaxis, G.; Skern, T.
Investigating the substrate specificity and oligomerisation of the leader protease of foot and mouth disease virus using NMR
J. Mol. Biol.
373
1071-1087
2007
Foot-and-mouth disease virus
Manually annotated by BRENDA team
de Los Santos, T.; Diaz-San Segundo, F.; Grubman, M.J.
Degradation of nuclear factor kappa B during foot-and-mouth disease virus infection
J. Virol.
81
12803-12815
2007
Foot-and-mouth disease virus
Manually annotated by BRENDA team
Mayer, C.; Neubauer, D.; Nchinda, A.T.; Cencic, R.; Trompf, K.; Skern, T.
Residue L143 of the foot-and-mouth disease virus leader proteinase is a determinant of cleavage specificity
J. Virol.
82
4656-4659
2008
Foot-and-mouth disease virus (P03305)
Manually annotated by BRENDA team
Zunszain, P.A.; Knox, S.R.; Sweeney, T.R.; Yang, J.; Roque-Rosell, N.; Belsham, G.J.; Leatherbarrow, R.J.; Curry, S.
Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate
J. Mol. Biol.
395
375-389
2010
Foot-and-mouth disease virus
Manually annotated by BRENDA team
Wang, D.; Fang, L.; Luo, R.; Ye, R.; Fang, Y.; Xie, L.; Chen, H.; Xiao, S.
Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced type I interferon transcription by decreasing interferon regulatory factor 3/7 in protein levels
Biochem. Biophys. Res. Commun.
399
72-78
2010
Foot-and-mouth disease virus
Manually annotated by BRENDA team
Nogueira Santos, J.A.; Assis, D.M.; Gouvea, I.E.; Judice, W.A.; Izidoro, M.A.; Juliano, M.A.; Skern, T.; Juliano, L.
Foot and mouth disease leader protease (Lb(pro)): Investigation of prime side specificity allows the synthesis of a potent inhibitor
Biochimie
94
711-718
2011
Foot-and-mouth disease virus
Manually annotated by BRENDA team
Piccone, M.E.; Diaz-San Segundo, F.; Kramer, E.; Rodriguez, L.L.; de los Santos, T.
Introduction of tag epitopes in the inter-AUG region of foot and mouth disease virus: effect on the L protein
Virus Res.
155
91-97
2011
Foot-and-mouth disease virus
Manually annotated by BRENDA team
Xu, Y.; Li, X.; Li, R.; Li, S.; Ni, H.; Wang, H.; Xu, H.; Zhou, W.; Saris, P.E.; Yang, W.; Qiao, M.; Rao, Z.
Structure of the nisin leader peptidase NisP revealing a C-terminal autocleavage activity
Acta Crystallogr. Sect. D
70
1499-1505
2014
Lactococcus lactis (D9IXC0), Lactococcus lactis
Manually annotated by BRENDA team
Dhiman, H.; Dhanjal, J.K.; Sharma, S.; Chacko, S.; Grover, S.; Grover, A.
Resisting resistant Mycobacterium tuberculosis naturally: mechanistic insights into the inhibition of the parasites sole signal peptidase Leader peptidase B
Biochem. Biophys. Res. Commun.
433
552-557
2013
Mycobacterium tuberculosis (P9WKA1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKA1)
Manually annotated by BRENDA team
Steinberger, J.; Skern, T.
The leader proteinase of foot-and-mouth disease virus: structure-function relationships in a proteolytic virulence factor
Biol. Chem.
395
1179-1185
2014
Foot-and-mouth disease virus
Manually annotated by BRENDA team
Steinberger, J.; Kontaxis, G.; Rancan, C.; Skern, T.
Comparison of self-processing of foot-and-mouth disease virus leader proteinase and porcine reproductive and respiratory syndrome virus leader proteinase nsp1alpha
Virology
443
271-277
2013
Foot-and-mouth disease virus, porcine reproductive and respiratory syndrome virus
Manually annotated by BRENDA team
Steinberger, J.; Grishkovskaya, I.; Cencic, R.; Juliano, L.; Juliano, M.A.; Skern, T.
Foot-and-mouth disease virus leader proteinase: structural insights into the mechanism of intermolecular cleavage
Virology
468-470
397-408
2014
Foot-and-mouth disease virus (P03305)
Manually annotated by BRENDA team
Shan, H.; Pasin, F.; Valli, A.; Castillo, C.; Rajulu, C.; Carbonell, A.; Simon-Mateo, C.; Garcia, J.A.; Rodamilans, B.
The Potyviridae P1a leader protease contributes to host range specificity
Virology
476
264-270
2015
cucumber vein yellowing virus (Q1G2C1), cucumber vein yellowing virus
Manually annotated by BRENDA team
Lagedroste, M.; Smits, S.H.J.; Schmitt, L.
Substrate specificity of the secreted nisin leader peptidase NisP
Biochemistry
56
4005-4014
2017
Lactococcus lactis subsp. lactis (Q07596)
Manually annotated by BRENDA team
Rodriguez Pulido, M.; Sanchez-Aparicio, M.T.; Martinez-Salas, E.; Garcia-Sastre, A.; Sobrino, F.; Saiz, M.
Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus
PLoS Pathog.
14
e1007135
2018
Foot-and-mouth disease virus
Manually annotated by BRENDA team
Atallah, O.; Kang, S.; El-Mohtar, C.; Shilts, T.; Bergua, M.; Folimonova, S.
A 5-proximal region of the Citrus tristeza virus genome encoding two leader proteases is involved in virus superinfection exclusion
Virology
489
108-115
2016
Citrus tristeza virus
Manually annotated by BRENDA team