3.4.22.46: L-peptidase

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For detailed information about L-peptidase, go to the full flat file.

Reaction

autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-/-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-/-Arg- and -Lys-/-Arg- =

Synonyms

3C protease, 3Cpro, Eukaryotic signal peptidase, Eukaryotic signal proteinase, FMDV 3Cpro, foot-and-mouth disease virus 3C protease, L protein, L proteinase, Lab protein, Lb proC, Lbpro, Leader peptidase, leader peptidase B, leader peptidase NisP, Leader peptide hydrolase, leader protease, Leader proteinase, leaderprotease L1, leaderprotease L2, LepB, Lpro, nisin leader peptidase, NisP, nsp1alpha, P1a protein, Peptidase, signal, Prokaryotic leader peptidase, Prokaryotic signal peptidase, Prokaryotic signal proteinase, Propeptidase, Proteinase, eukaryotic signal, Proteinase, signal, Signal peptidase, Signalase, sLbpro

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.46 L-peptidase

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Results	in table
15	AA Sequence
1	Application
1	CAS Registry Number
18	Cloned(Commentary)
4	Crystallization (Commentary)
11	General Information
11	Inhibitors
6	Ki Value [mM]
1	KM Value [mM]
2	Localization
11	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
40	Organism
26	PDB ID
4	pH Optimum
1	pH Range
2	Posttranslational Modification
26	Protein Variants
8	Purification (Commentary)
1	Reaction
1	Reaction Type
33	Reference
1	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
62	Substrates and Products (Substrate)
9	Subunits
67	Synonyms
3	Temperature Optimum [°C]

KM Value

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KM Value on EC 3.4.22.46 - L-peptidase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0227

Val-Gln-Arg-Lys-Leu-Lys-4-methylcoumarin 7-amide

Foot-and-mouth disease virus

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137299