3.4.22.46: L-peptidase

This is an abbreviated version!
For detailed information about L-peptidase, go to the full flat file.

Reaction

autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-/-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-/-Arg- and -Lys-/-Arg- =

Synonyms

3C protease, 3Cpro, Eukaryotic signal peptidase, Eukaryotic signal proteinase, FMDV 3Cpro, foot-and-mouth disease virus 3C protease, L protein, L proteinase, Lab protein, Lb proC, Lbpro, Leader peptidase, leader peptidase B, leader peptidase NisP, Leader peptide hydrolase, leader protease, Leader proteinase, leaderprotease L1, leaderprotease L2, LepB, Lpro, nisin leader peptidase, NisP, nsp1alpha, P1a protein, Peptidase, signal, Prokaryotic leader peptidase, Prokaryotic signal peptidase, Prokaryotic signal proteinase, Propeptidase, Proteinase, eukaryotic signal, Proteinase, signal, Signal peptidase, Signalase, sLbpro

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.46 L-peptidase

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Results	in table
15	AA Sequence
1	Application
1	CAS Registry Number
18	Cloned(Commentary)
4	Crystallization (Commentary)
11	General Information
11	Inhibitors
6	Ki Value [mM]
1	KM Value [mM]
2	Localization
11	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
40	Organism
26	PDB ID
4	pH Optimum
1	pH Range
2	Posttranslational Modification
26	Protein Variants
8	Purification (Commentary)
1	Reaction
1	Reaction Type
33	Reference
1	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
62	Substrates and Products (Substrate)
9	Subunits
67	Synonyms
3	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 3.4.22.46 - L-peptidase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

(2S,3R,4R)-2-{[2-(2,3-dihydroxyphenyl)-5,8-dihydroxy-4-oxo-4H-chromen-7-yl]oxy}-4-hydroxy-4-(hydroxymethyl)tetrahydrofuran-3-yl alpha-D-galactopyranoside

Mycobacterium tuberculosis

P9WKA1

-

731252

2-(3,4-dihydroxyphenyl)ethyl 4-O-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-6-O-alpha-L-lyxopyranosyl-beta-D-glucopyranoside

Mycobacterium tuberculosis

P9WKA1

-

731252

CA074

2 entries

E64

Foot-and-mouth disease virus

-

epoxide-based inhibitor of cysteine proteinases, two-step overall irreversible inhibition, with step one being reversible and step two irreversible. Extending E64 by addition of the dipeptide R-P to a compound termed E64-R-P-NH2, which irreversibly inhibits Lbpro with a Ki of 30 nM and k4 of 0.01/min, can serve as the basis for design of specific inhibitors of FMDV replication

717297

E64-R-P-NH2

2 entries

trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane

2 entries

additional information

2 entries

-

CA074

Foot-and-mouth disease virus

-

epoxide-based inhibitor of cysteine proteinases, two-step overall irreversible inhibition, with step one being reversible and step two irreversible

717297

CA074

Foot-and-mouth disease virus

P03305

-

732975

E64-R-P-NH2

Foot-and-mouth disease virus

-

extending E64 by addition of the dipeptide R-P to a compound termed E64-R-P-NH2, which irreversibly inhibits Lbpro with a Ki of 30 nM and k4 of 0.01/min, can serve as the basis for design of specific inhibitors of FMDV replication

717297

E64-R-P-NH2

Foot-and-mouth disease virus

P03305

-

732975

trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane

Foot-and-mouth disease virus

-

i.e. E-64

137298

trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane

Foot-and-mouth disease virus

-

-

137303

additional information

Foot-and-mouth disease virus

-

sensitive to high ionic strength, 50% inactivation by 20 mM NaCl or 10 mM CaCl2

137299

-

additional information

porcine reproductive and respiratory syndrome virus

-

self-processing inactivates leader proteinase nsp1alpha

732973

-