3.4.22.45: helper-component proteinase
This is an abbreviated version!
For detailed information about helper-component proteinase, go to the full flat file.
Word Map on EC 3.4.22.45
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3.4.22.45
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viruses
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potato
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nicotiana
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potyviruses
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polyproteins
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benthamiana
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potyviral
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aphid
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potyviridae
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mottle
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etch
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turnip
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cistron
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plum
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zucchini
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ringspot
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papaya
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nia-pro
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cucurbit
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tritimovirus
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non-persistent
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ipomovirus
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pvyntn
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genome-linked
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rna-silencing
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veinal
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feathery
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agriculture
- 3.4.22.45
- viruses
- potato
- nicotiana
- potyviruses
- polyproteins
- benthamiana
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potyviral
- aphid
- potyviridae
-
mottle
-
etch
- turnip
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cistron
- plum
- zucchini
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ringspot
- papaya
- nia-pro
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cucurbit
- tritimovirus
-
non-persistent
- ipomovirus
-
pvyntn
-
genome-linked
-
rna-silencing
-
veinal
-
feathery
- agriculture
Reaction
hydrolyses a Gly-/-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-/-Gly, in the processing of the potyviral polyprotein =
Synonyms
HC-Pro, HC-Pro protein, HC-Pro proteinase, HcPro, helper component protease, helper component proteinase, helper component-protease, helper component-proteinase, helper-component proteinase, More, potyvirus helper component proteinase, PVA HC-Pro, strong silencing suppressor P1
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Reference on EC 3.4.22.45 - helper-component proteinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kasschau, K.D.; Carrington, J.C.
Requirement for HC-Pro processing during genome amplification of tobacco etch potyvirus
Virology
209
268-273
1995
tobacco etch virus
Verchot, J.
Potyvirus helper component proteinase
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
677-679
1998
barley yellow mosaic virus, Johnsongrass mosaic virus, papaya ringspot virus, Pea seed-borne mosaic virus, Peanut stripe virus, pepper mottle virus, Plum pox virus, Potato virus Y strain C, potato virus Y, tobacco vein mottling virus, turnip mosaic virus, zucchini yellow mosaic virus
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Urcuqui-Inchima, S.; Walter, J.; Drugeon, G.; German-Retana, S.; Haenni, A.L.; Candresse, T.; Bernardi, F.; Le Gall, O.
Potyvirus helper component-proteinase self-interaction in the yeast two-hybrid system and delineation of the interaction domain involved
Virology
258
95-99
1999
lettuce mosaic virus, potato virus Y
Urcuqui-Inchima, S.; Maia, I.G.; Drugeon, G.; Haenni, A.L.; Bernardi, F.
Effect of mutations within the cys-rich region of potyvirus helper component-proteinase on self-interaction
J. Gen. Virol.
80
2809-2812
1999
potato virus Y
Andrejeva, J.; Puurand, U.; Merits, A.; Rabenstein, F.; Jarvekulg, L.; Valkonen, J.P.
Potyvirus helper component-proteinase and coat protein (CP) have coordinated functions in virus-host interactions and the same CP motif affects virus transmission and accumulation
J. Gen. Virol.
80
1133-1139
1999
potato virus A
Maia, I.G.; Bernardi, F.
Nucleic acid-binding properties of a bacterially expressed potato virus Y helper component-proteinase
J. Gen. Virol.
77
869-877
1996
potato virus Y
Maia, I.G.; Haenni, A.L.; Bernardi, F.
Potyviral HC-Pro: a multifunctional protein
J. Gen. Virol.
77
1335-1341
1996
Potato virus Y strain C, potato virus Y, tobacco etch virus, tobacco vein mottling virus, zucchini yellow mosaic virus
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Atreya, C.D.; Pirone, T.P.
Mutational analysis of the helper component-proteinase gene of a potyvirus: effects of amino acid substitutions, deletions, and gene replacement on virulence and aphid transmissibility
Proc. Natl. Acad. Sci. USA
90
11919-11923
1993
tobacco vein mottling virus
Atreya, C.D.; Atreya, P.L.; Thornbury, D.W.; Pirone, T.P.
Site-directed mutations in the potyvirus HC-Pro gene affect helper component activity, virus accumulation, and symptom expression in infected tobacco plants
Virology
191
106-111
1992
tobacco vein mottling virus
Carrington, J.C.; Herndon, K.L.
Characterization of the potyviral HC-pro autoproteolytic cleavage site
Virology
187
308-315
1992
tobacco etch virus
Plisson, C.; Drucker, M.; Blanc, S.; German-Retana, S.; Le Gall, O.; Thomas, D.; Bron, P.
Structural characterization of HC-Pro, a plant virus multifunctional protein
J. Biol. Chem.
278
23753-23761
2003
lettuce mosaic virus
Verchot-Lubicz, J.
Potyvirus helper component proteinase
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press
2
1262-1264
2004
Tobacco vein mottling potyvirus
-
Verchot-Lubicz, J.
Potyvirus helper component proteinase
Handbook of Proteolytic Enzymes (Barrett, A. J. ; Rawlings, N. D. ; Woessner, J. F. ; eds. )
2
1262-1264
2004
tobacco etch virus
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Ruiz-Ferrer, V.; Goytia, E.; Martinez-Garcia, B.; Lopez-Abella, D.; Lopez-Moya, J.J.
Expression of functionally active helper component protein of Tobacco etch potyvirus in the yeast Pichia pastoris
J. Gen. Virol.
85
241-249
2004
tobacco etch virus
Ballut, L.; Drucker, M.; Pugniere, M.; Cambon, F.; Blanc, S.; Roquet, F.; Candresse, T.; Schmid, H.P.; Nicolas, P.; Gall, O.L.; Badaoui, S.
HcPro, a multifunctional protein encoded by a plant RNA virus, targets the 20S proteasome and affects its enzymic activities
J. Gen. Virol.
86
2595-2603
2005
lettuce mosaic virus
Stenger, D.C.; Hein, G.L.; Gildow, F.E.; Horken, K.M.; French, R.
Plant virus HC-Pro is a determinant of eriophyid mite transmission
J. Virol.
79
9054-9061
2005
Wheat streak mosaic virus
Gonzalez-Jara, P.; Atencio, F.A.; Martinez-Garcia, B.; Barajas, D.; Tenllado, F.; Diaz-Ruiz, J.R.
A single amino acid mutation in the Plum pox virus helper component-proteinase gene abolishes both synergistic and RNA silencing suppression activities
Phytopathology
95
894-901
2005
Plum pox virus
Lim, H.S.; Ko, T.S.; Lambert, K.N.; Kim, H.G.; Korban, S.S.; Hartman, G.L.; Domier, L.L.
Soybean mosaic virus helper component-protease enhances somatic embryo production and stabilizes transgene expression in soybean
Plant Physiol. Biochem.
43
1014-1021
2005
Soybean mosaic virus
Ebhardt, H.A.; Thi, E.P.; Wang, M.B.; Unrau, P.J.
Extensive 3 modification of plant small RNAs is modulated by helper component-proteinase expression
Proc. Natl. Acad. Sci. USA
102
13398-13403
2005
Cucumber mosaic virus
Stenger, D.C.; Hein, G.L.; French, R.
Nested deletion analysis of Wheat streak mosaic virus HC-Pro: mapping of domains affecting polyprotein processing and eriophyid mite transmission
Virology
350
465-474
2006
Wheat streak mosaic virus
Young, B.A.; Hein, G.L.; French, R.; Stenger, D.C.
Substitution of conserved cysteine residues in wheat streak mosaic virus HC-Pro abolishes virus transmission by the wheat curl mite
Arch. Virol.
152
2107-2111
2007
Wheat streak mosaic virus
Yambao, M.L.; Yagihashi, H.; Sekiguchi, H.; Sekiguchi, T.; Sasaki, T.; Sato, M.; Atsumi, G.; Tacahashi, Y.; Nakahara, K.S.; Uyeda, I.
Point mutations in helper component protease of clover yellow vein virus are associated with the attenuation of RNA-silencing suppression activity and symptom expression in broad bean
Arch. Virol.
153
105-115
2008
clover yellow vein virus
Stenger, D.C.; Young, B.A.; French, R.
Random mutagenesis of wheat streak mosaic virus HC-Pro: non-infectious interfering mutations in a gene dispensable for systemic infection of plants
J. Gen. Virol.
87
2741-2747
2006
Wheat streak mosaic virus
Varrelmann, M.; Maiss, E.; Pilot, R.; Palkovics, L.
Use of pentapeptide-insertion scanning mutagenesis for functional mapping of the plum pox virus helper component proteinase suppressor of gene silencing
J. Gen. Virol.
88
1005-1015
2007
Plum pox virus (P17766), Plum pox virus, Plum pox virus PPV (P17766)
Dombrovsky, A.; Gollop, N.; Chen, S.; Chejanovsky, N.; Raccah, B.
In vitro association between the helper component-proteinase of zucchini yellow mosaic virus and cuticle proteins of Myzus persicae
J. Gen. Virol.
88
1602-1610
2007
zucchini yellow mosaic virus (P18479), zucchini yellow mosaic virus, zucchini yellow mosaic virus ZYMV (P18479)
Jin, Y.; Ma, D.; Dong, J.; Jin, J.; Li, D.; Deng, C.; Wang, T.
HC-Pro protein of Potato virus Y can interact with three Arabidopsis 20S proteasome subunits in planta
J. Virol.
81
12881-12888
2007
potato virus Y (P18247), potato virus Y, potato virus Y N (P18247)
Shiboleth, Y.M.; Haronsky, E.; Leibman, D.; Arazi, T.; Wassenegger, M.; Whitham, S.A.; Gaba, V.; Gal-On, A.
The conserved FRNK box in HC-Pro, a plant viral suppressor of gene silencing, is required for small RNA binding and mediates symptom development
J. Virol.
81
13135-13148
2007
zucchini yellow mosaic virus (P18479), zucchini yellow mosaic virus, zucchini yellow mosaic virus ZYMV (P18479)
L, M.; Y, H.; Schubert, J.; P, X.
Sequence analysis of CP and HC-Pro genes of Turnip mosaiv virus isolates from china
Acta Virol.
52
59-62
2008
turnip mosaic virus
Gadiou, S.; Safarova, D.; Navratil, M.
Differentiation of Plum pox virus isolates by single-strand conformation polymorphism and low-stringency single specific primer PCR analysis of HC-Pro genome region
Acta Virol.
53
53-56
2009
Plum pox virus
Torres-Barcelo, C.; Martin, S.; Daros, J.A.; Elena, S.F.
From hypo- to hypersuppression: effect of amino acid substitutions on the RNA-silencing suppressor activity of the Tobacco etch potyvirus HC-Pro
Genetics
180
1039-1049
2008
tobacco etch virus
Eggenberger, A.L.; Hajimorad, M.R.; Hill, J.H.
Gain of virulence on Rsv1-genotype soybean by an avirulent Soybean mosaic virus requires concurrent mutations in both P3 and HC-Pro
Mol. Plant Microbe Interact.
21
931-936
2008
Soybean mosaic virus
Hajimorad, M.R.; Eggenberger, A.L.; Hill, J.H.
Adaptation of Soybean mosaic virus avirulent chimeras containing P3 sequences from virulent strains to Rsv1-genotype soybeans is mediated by mutations in HC-Pro
Mol. Plant Microbe Interact.
21
937-946
2008
Soybean mosaic virus
Zhang, X.; Du, P.; Lu, L.; Xiao, Q.; Wang, W.; Cao, X.; Ren, B.; Wei, C.; Li, Y.
Contrasting effects of HC-Pro and 2b viral suppressors from Sugarcane mosaic virus and Tomato aspermy cucumovirus on the accumulation of siRNAs
Virology
374
351-360
2008
Sugarcane mosaic virus
Yap, Y.K.; Duangjit, J.; Panyim, S.
N-terminal of Papaya ringspot virus type-W (PRSV-W) helper component proteinase (HC-Pro) is essential for PRSV systemic infection in zucchini
Virus Genes
38
461-467
2009
papaya ringspot virus, papaya ringspot virus type-W
Li, W.; Hilf, M.E.; Webb, S.E.; Baker, C.A.; Adkins, S.
Presence of P1b and absence of HC-Pro in Squash vein yellowing virus suggests a general feature of the genus Ipomovirus in the family Potyviridae
Virus Res.
135
213-219
2008
no activity in Squash vein yellowing virus
Ma, P.; Liu, J.; He, H.; Yang, M.; Li, M.; Zhu, X.; Wang, X.
A viral suppressor P1/HC-Pro increases the GFP gene expression in agrobacterium-mediated transient assay
Appl. Biochem. Biotechnol.
158
243-252
2009
tobacco etch virus
Torres-Barcelo, C.; Daros, J.A.; Elena, S.F.
HC-Pro hypo- and hypersuppressor mutants: differences in viral siRNA accumulation in vivo and siRNA binding activity in vitro
Arch. Virol.
155
251-254
2010
tobacco etch virus
Desbiez, C.; Girard, M.; Lecoq, H.
A novel natural mutation in HC-Pro responsible for mild symptomatology of Zucchini yellow mosaic virus (ZYMV, Potyvirus) in cucurbits
Arch. Virol.
155
397-401
2010
zucchini yellow mosaic virus
Mbanzibwa, D.R.; Tian, Y.; Mukasa, S.B.; Valkonen, J.P.
Cassava brown streak virus (Potyviridae) encodes a putative Maf/HAM1 pyrophosphatase implicated in reduction of mutations and a P1 proteinase that suppresses RNA silencing but contains no HC-Pro
J. Virol.
83
6934-6940
2009
no activity in cassava brown streak virus
Torres-Barcelo, C.; Daros, J.A.; Elena, S.F.
Compensatory molecular evolution of HC-Pro, an RNA-silencing suppressor from a plant RNA virus
Mol. Biol. Evol.
27
543-551
2010
tobacco etch virus
Mangrauthia, S.K.; Singh, P.; Praveen, S.
Genomics of helper component proteinase reveals effective strategy for papaya ringspot virus resistance
Mol. Biotechnol.
44
22-29
2010
papaya ringspot virus (B2CZ54), papaya ringspot virus (Q06IX7), papaya ringspot virus
Wu, H.W.; Lin, S.S.; Chen, K.C.; Yeh, S.D.; Chua, N.H.
Discriminating mutations of HC-Pro of zucchini yellow mosaic virus with differential effects on small RNA pathways involved in viral pathogenicity and symptom development
Mol. Plant Microbe Interact.
23
17-28
2010
zucchini yellow mosaic virus
Seo, J.K.; Kang, S.H.; Seo, B.Y.; Jung, J.K.; Kim, K.H.
Mutational analysis of interaction between coat protein and helper component-proteinase of Soybean mosaic virus involved in aphid transmission
Mol. Plant Pathol.
11
265-276
2010
Soybean mosaic virus
Shen, W.; Yan, P.; Gao, L.; Pan, X.; Wu, J.; Zhou, P.
Helper component-proteinase (HC-Pro) protein of Papaya ringspot virus interacts with papaya calreticulin
Mol. Plant Pathol.
11
335-346
2010
papaya ringspot virus
Fukuzawa, N.; Itchoda, N.; Ishihara, T.; Goto, K.; Masuta, C.; Matsumura, T.
HC-Pro, a potyvirus RNA silencing suppressor, cancels cycling of Cucumber mosaic virus in Nicotiana benthamiana plants
Virus Genes
40
440-446
2010
potato virus Y
Boonrod, K.; Fuellgrabe, M.W.; Krczal, G.; Wassenegger, M.
Analysis of the autoproteolytic activity of the recombinant helper component proteinase from zucchini yellow mosaic virus
Biol. Chem.
392
937-945
2011
zucchini yellow mosaic virus
Jamous, R.M.; Boonrod, K.; Fuellgrabe, M.W.; Ali-Shtayeh, M.S.; Krczal, G.; Wassenegger, M.
The helper component-proteinase of the Zucchini yellow mosaic virus inhibits the Hua Enhancer 1 methyltransferase activity in vitro
J. Gen. Virol.
92
2222-2226
2011
zucchini yellow mosaic virus
Ala-Poikela, M.; Goytia, E.; Haikonen, T.; Rajamaeki, M.L.; Valkonen, J.P.
Helper component proteinase of the genus Potyvirus is an interaction partner of translation initiation factors eIF(iso)4E and eIF4E and contains a 4E binding motif
J. Virol.
85
6784-6794
2011
potato virus Y (G2ZHC9), potato virus Y, tobacco etch virus (Q000U0), potato virus A (Q9DIC2), potato virus A, tobacco etch virus TEV-HCH10 (Q000U0), potato virus A PVA-B11 (Q9DIC2), potato virus Y PVY-Nevski (G2ZHC9)
Fuellgrabe, M.W.; Boonrod, K.; Jamous, R.; Moser, M.; Shiboleth, Y.; Krczal, G.; Wassenegger, M.
Expression, purification and functional characterization of recombinant Zucchini yellow mosaic virus HC-Pro
Protein Expr. Purif.
75
40-45
2011
zucchini yellow mosaic virus (A1DU45), zucchini yellow mosaic virus
Siriwan, W.; Takaya, N.; Roytrakul, S.; Chowpongpang, S.
Study of interaction between Papaya ringspot virus HC-Pro and papaya (Carica papaya) proteins
J. Gen. Plant Pathol.
80
264-271
2014
papaya ringspot virus
Haikonen, T.; Rajamaeki, M.L.; Valkonen, J.P.
Improved silencing suppression and enhanced heterologous protein expression are achieved using an engineered viral helper component proteinase
J. Virol. Methods
193
687-692
2013
potato virus A (Q9DIC2), potato virus A
Valli, A.; Gallo, A.; Calvo, M.; de Jesus Perez, J.; Garcia, J.A.
A novel role of the potyviral helper component proteinase contributes to enhance the yield of viral particles
J. Virol.
88
9808-9818
2014
Plum pox virus
Haikonen, T.; Rajamaeki, M.L.; Tian, Y.P.; Valkonen, J.P.
Mutation of a short variable region in HCpro protein of potato virus A affects interactions with a microtubule-associated protein and induces necrotic responses in tobacco
Mol. Plant Microbe Interact.
26
721-733
2013
potato virus Y, tobacco etch virus, potato virus Y Nevski, tobacco etch virus HCH10
Haikonen, T.; Rajamaeki, M.L.; Valkonen, J.P.
Interaction of the microtubule-associated host protein HIP2 with viral helper component proteinase is important in infection with potato virus A
Mol. Plant Microbe Interact.
26
734-744
2013
potato virus A
Lim, H.; Jang, C.; Nam, J.; Li, M.; Hong, J.; Bae, H.; Ju, H.; Kim, H.; Ford, R.; Domier, L.
Characterization of the in vitro activities of the P1 and helper component proteases of Soybean mosaic virus strain G2 and Tobacco vein mottling virus
Plant Pathol. J.
28
197-201
2012
tobacco vein mottling virus, Soybean mosaic virus
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Tahmasebi, A.A.; Afsharifar, A.
Cap analog and Potato virus A HC-Pro silencing suppressor improve GFP transient expression using an infectious virus vector in Nicotiana benthamiana
Mol. Biol. Res. Commun.
6
45-56
2017
potato virus A
Geng, C.; Wang, H.Y.; Liu, J.; Yan, Z.Y.; Tian, Y.P.; Yuan, X.F.; Gao, R.; Li, X.D.
Transcriptomic changes in Nicotiana benthamiana plants inoculated with the wild-type or an attenuated mutant of Tobacco vein banding mosaic virus
Mol. Plant Pathol.
18
1175-1188
2017
tobacco vein banding mosaic virus
Valli, A.A.; Gallo, A.; Rodamilans, B.; Lopez-Moya, J.J.; Garcia, J.A.
The HCPro from the Potyviridae family an enviable multitasking Helper Component that every virus would like to have
Mol. Plant Pathol.
19
744-763
2018
clover yellow vein virus, lettuce mosaic virus, papaya ringspot virus, Pea seed-borne mosaic virus, potato virus A, potato virus Y, tobacco etch virus, turnip mosaic virus, Wheat streak mosaic virus, Sugarcane mosaic virus
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