3.4.22.41: cathepsin F

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For detailed information about cathepsin F, go to the full flat file.

Reaction

The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (kcat/Km) comparable to that of cathepsin L =

Synonyms

cat F, CatF, cathepsin f, cathepsin F-1, CATSF, CF-1, CF-11, CF-4, CF-6, cf1, CtF, CTSF, Ov-CF-1, PwCP1, PwCP10, PwCP11, PwCP2, PwCP3, PwCP4, PwCP5, PwCP6, PwCP7, PwCP8, PwCP9, Tci-CF-1

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.41 cathepsin F

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Results	in table
9	Activating Compound
53	AA Sequence
6	Application
1	CAS Registry Number
20	Cloned(Commentary)
2	Crystallization (Commentary)
46	Disease/ Diagnostics
4	Expression
3	General Information
28	Inhibitors
4	kcat/KM [mM/s]
6	KM Value [mM]
16	Localization
3	Metals/Ions
17	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
40	Organism
2	PDB ID
7	pH Optimum
5	pH Range
7	pH Stability
2	pI Value
7	Posttranslational Modification
2	Protein Variants
6	Purification (Commentary)
2	Reaction
2	Reaction Type
30	Reference
1	Renatured (Commentary)
87	Source Tissue
4	Specific Activity [micromol/min/mg]
2	Storage Stability
47	Substrates and Products (Substrate)
5	Subunits
33	Synonyms
1	Temperature Optimum [°C]
6	Turnover Number [1/s]

pH Range

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pH Range on EC 3.4.22.41 - cathepsin F

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3.5 - 8.5

Opisthorchis viverrini

-

-

708053

4.5 - 6

Opisthorchis viverrini

Q5PXS3

modest enzyme activity, substrates hemoglobin and gelatin

700877

4.5 - 8

Opisthorchis viverrini

Q5PXS3

substrate benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide

700877

6.5 - 8.5

Paralichthys olivaceus

B2Z446

-

708220

additional information

Homo sapiens

-

slightly acidic pH optimum, rapid inactivation at neutral pH

669249