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3.4.22.41: cathepsin F

This is an abbreviated version!
For detailed information about cathepsin F, go to the full flat file.

Word Map on EC 3.4.22.41

Reaction

The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (kcat/Km) comparable to that of cathepsin L =

Synonyms

cat F, CatF, cathepsin f, cathepsin F-1, CATSF, CF-1, CF-11, CF-4, CF-6, cf1, CtF, CTSF, Ov-CF-1, PwCP1, PwCP10, PwCP11, PwCP2, PwCP3, PwCP4, PwCP5, PwCP6, PwCP7, PwCP8, PwCP9, Tci-CF-1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.41 cathepsin F

Substrates Products

Substrates Products on EC 3.4.22.41 - cathepsin F

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Albumin + H2O
?
show the reaction diagram
-
substrate of isozyme CF-4 at pH 6.5 and CF-11 at pH 5.5 but not at neutral pH
-
-
?
apoB-100 + H2O
?
show the reaction diagram
-
apoB-100 is part of LDL particles
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
low activity
-
-
?
benzyloxycarbonyl-L-leucine-L-arginine-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-leucine-L-arginine + 7-amino-4-methylcoumarin
show the reaction diagram
-
high catalytic activity with isozymes CF-4 and CF-11
-
-
?
benzyloxycarbonyl-L-leucyl-L-arginyl-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-leucyl-L-arginine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-L-phenylalanine-L-arginine-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-phenylalanine-L-arginine + 7-amino-4-methylcoumarin
show the reaction diagram
-
high catalytic activity with isozymes CF-4 and CF-11
-
-
?
benzyloxycarbonyl-Leu-Arg-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Leu-Arg-4-methylcoumaryl-7-amide + H2O
benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
high activity
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
high activity
-
-
?
benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
very low activity
-
-
?
Collagen + H2O
?
show the reaction diagram
-
substrate of isozyme CF-4 at pH 6.5 and CF-11 at pH 5.5 but not at neutral pH
-
-
?
Gelatin + H2O
?
show the reaction diagram
purified CtF is capable of hydrolyzing 0.1% gelatin at pH 7.5
-
-
?
Hemoglobin + H2O
?
show the reaction diagram
Ii-MHC class II complex + H2O
?
show the reaction diagram
-
-
-
-
?
immunoglobulin A + H2O
?
show the reaction diagram
-
substrate of isozyme CF-4 at pH 6.5 and CF-11 at pH 5.5 but not at neutral pH
-
-
?
immunoglobulin G + H2O
?
show the reaction diagram
-
substrate of isozyme CF-4 at pH 6.5 and CF-11 at pH 5.5 but not at neutral pH
-
-
?
immunoglobulin M + H2O
?
show the reaction diagram
-
substrate of isozyme CF-4 at pH 6.5 and CF-11 at pH 5.5 but not at neutral pH
-
-
?
LAMP 2 protein + H2O
?
show the reaction diagram
-
-
-
-
?
N-acetyl-DEVD-7-amido-4-trifluoromethylcoumarin + H2O
N-acetyl-DEVD + 7-amino-4-trifluoromethylcoumarin
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-L-Arg-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
?
N-benzyloxycarbonyl-L-Leu-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Leu-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
N-benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
N-benzyloxycarbonyl-L-Val-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Val-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
?
Pro-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
very low activity
-
-
?
tert-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
very low activity
-
-
?
tert-butyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
highest activity
-
-
?
tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
very low activity
-
-
?
tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
very low activity
-
-
?
tosyl-Gly-Pro-Lys-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
very low activity
-
-
?
additional information
?
-