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3.4.22.41: cathepsin F

This is an abbreviated version!
For detailed information about cathepsin F, go to the full flat file.

Word Map on EC 3.4.22.41

Reaction

The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (kcat/Km) comparable to that of cathepsin L =

Synonyms

cat F, CatF, cathepsin f, cathepsin F-1, CATSF, CF-1, CF-11, CF-4, CF-6, cf1, CtF, CTSF, Ov-CF-1, PwCP1, PwCP10, PwCP11, PwCP2, PwCP3, PwCP4, PwCP5, PwCP6, PwCP7, PwCP8, PwCP9, Tci-CF-1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.41 cathepsin F

Inhibitors

Inhibitors on EC 3.4.22.41 - cathepsin F

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
15.28% inhibition at 0.1 mM
antipain
complete inhibition at 0.1 mM
Aprotinin
36.94% inhibition at 0.1 mM
Chloroquine
-
-
chymostatin
35.42% inhibition at 0.1 mM
Co2+
6.85% residual activity at 5 mM
Cu2+
11.6% residual activity at 5 mM
cystatin B
-
-
-
EDTA
6.52% inhibition at 0.1 mM
EGTA
4.72% inhibition at 0.1 mM
Hg2+
0.81% residual activity at 5 mM
JPM565
-
radioactive-labeling by 125I, irrevrsible inhibitor of papin-type cathepsins, active site labeling
leupeptin
complete inhibition at 0.1 mM
morpholine urea-Leu-homophenylalaninevinyl sulfone-phenyl
NEM
44.59% inhibition at 0.1 mM
phenylmethylsufonyl fluoride
13.22% inhibition at 0.1 mM
SDS
complete inhibition at 0.05% (w/v)
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
Z-VAD(OMe)-fluoromethylketone
-
-
Zn2+
5.94% residual activity at 1 mM
additional information
-