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3.4.22.41: cathepsin F

This is an abbreviated version!
For detailed information about cathepsin F, go to the full flat file.

Word Map on EC 3.4.22.41

Reaction

The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (kcat/Km) comparable to that of cathepsin L =

Synonyms

cat F, CatF, cathepsin f, cathepsin F-1, CATSF, CF-1, CF-11, CF-4, CF-6, cf1, CtF, CTSF, Ov-CF-1, PwCP1, PwCP10, PwCP11, PwCP2, PwCP3, PwCP4, PwCP5, PwCP6, PwCP7, PwCP8, PwCP9, Tci-CF-1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.41 cathepsin F

Activating Compound

Activating Compound on EC 3.4.22.41 - cathepsin F

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Brij 35
273.6% relative activity at 0.01% (v/v)
chondroitin-4-sulfate
-
activates apoB-100/LDL degradation by cathepsin F
chondroitin-6-sulfate
-
activates apoB-100/LDL degradation by cathepsin F
dermatan sulfate
-
activates apoB-100/LDL degradation by cathepsin F
heparan sulfate
-
activates apoB-100/LDL degradation by cathepsin F
human aortic proteoglycans
-
activates apoB-100/LDL degradation by cathepsin F
-
Triton X-100
310.29% relative activity at 0.01% (v/v)
Tween 20
282.7% relative activity at 0.01% (v/v)
additional information
-
cathepsin F is secreted as an inactive zymogen that autocatalytically processes and activates to a mature enzyme at pH 4.5 (after 6 h incubation) via an intermolecular cleavage at the prosegment-mature domain junction, the active cathepsin B1 zymogen is capable of trans-activating cathepsin F by proteolytic removal of its prosegment at pH 5.5
-