3.4.22.40: bleomycin hydrolase

This is an abbreviated version!
For detailed information about bleomycin hydrolase, go to the full flat file.

Word Map on EC 3.4.22.40

3.4.22.40

luteinizing

paraoxonase

thiolactone

helveticus

peplomycin

lutropins

corneocytes

homocysteinylation

beta-naphthylamide

medicine

hcy-thiolactone

Reaction

Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred =

Synonyms

aminopeptidase C, aminopeptidase H, ApsC, BANA-hydrolase, BH, BH protein, Bleomycin hydrolase, BLH, Blh1p, BLM hydrolase, Blmh, BLMH protein, BMH, citrulline aminopeptidase, Gal6p, Hcy-thiolactonase, homocysteine thiolactonase, HTLase, hydrolase H, More, PEPC, yBLH, yeast cysteine protease

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.40 bleomycin hydrolase

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Results	in table
4	Activating Compound
2648	AA Sequence
9	Application
1	CAS Registry Number
18	Cloned(Commentary)
3	Crystallization (Commentary)
265	Disease/ Diagnostics
3	Expression
6	General Information
1	General Stability
6	IC50 Value
57	Inhibitors
7	kcat/KM [mM/s]
52	KM Value [mM]
15	Localization
1	Metals/Ions
18	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
51	Organism
13	PDB ID
15	pH Optimum
4	pH Range
1	Posttranslational Modification
13	Protein Variants
12	Purification (Commentary)
3	Reaction
1	Reaction Type
51	Reference
56	Source Tissue
9	Specific Activity [micromol/min/mg]
130	Substrates and Products (Substrate)
13	Subunits
44	Synonyms
4	Temperature Optimum [°C]
3	Temperature Stability [°C]
7	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.22.40 - bleomycin hydrolase

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0.805

6'-deoxy bleomycin A2

Homo sapiens

Q13867

pH 7.5, 30°C

753009

0.942

6'-deoxy bleomycin Z

Homo sapiens

Q13867

pH 7.5, 30°C

753009

0.72

6'-deoxy tallysomycin H1

Homo sapiens

Q13867

pH 7.5, 30°C

753009

17.4

Ala-p-nitroanilide