3.4.22.40: bleomycin hydrolase
This is an abbreviated version!
For detailed information about bleomycin hydrolase, go to the full flat file.
Word Map on EC 3.4.22.40
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3.4.22.40
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luteinizing
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paraoxonase
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thiolactone
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helveticus
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peplomycin
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lutropins
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corneocytes
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homocysteinylation
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beta-naphthylamide
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medicine
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hcy-thiolactone
- 3.4.22.40
-
luteinizing
- paraoxonase
- thiolactone
- helveticus
- peplomycin
-
lutropins
- corneocytes
-
homocysteinylation
- beta-naphthylamide
- medicine
-
hcy-thiolactone
Reaction
Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred =
Synonyms
aminopeptidase C, aminopeptidase H, ApsC, BANA-hydrolase, BH, BH protein, Bleomycin hydrolase, BLH, Blh1p, BLM hydrolase, Blmh, BLMH protein, BMH, citrulline aminopeptidase, Gal6p, Hcy-thiolactonase, homocysteine thiolactonase, HTLase, hydrolase H, More, PEPC, yBLH, yeast cysteine protease
ECTree
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Inhibitors
Inhibitors on EC 3.4.22.40 - bleomycin hydrolase
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(2-chlorophenyl)methyl [(5S)-5-amino-6-oxo-7-(2,3,5,6-tetrafluorophenoxy)heptyl]carbamate
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(2-chlorophenyl)methyl [(5S,6E)-5-amino-7-(benzenesulfonyl)hept-6-en-1-yl]carbamate
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(2-chlorophenyl)methyl [(5S,6E)-5-amino-7-(methanesulfonyl)hept-6-en-1-yl]carbamate
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(3S)-3-amino-7-([[(2-chlorophenyl)methoxy]carbonyl]amino)-2-oxoheptyl 2,6-dimethylbenzoate
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