3.4.22.40: bleomycin hydrolase

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For detailed information about bleomycin hydrolase, go to the full flat file.

Reaction

Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred =

Synonyms

aminopeptidase C, aminopeptidase H, ApsC, BANA-hydrolase, BH, BH protein, Bleomycin hydrolase, BLH, Blh1p, BLM hydrolase, Blmh, BLMH protein, BMH, citrulline aminopeptidase, Gal6p, Hcy-thiolactonase, homocysteine thiolactonase, HTLase, hydrolase H, More, PEPC, yBLH, yeast cysteine protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.40 bleomycin hydrolase

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Results	in table
4	Activating Compound
2648	AA Sequence
9	Application
1	CAS Registry Number
18	Cloned(Commentary)
3	Crystallization (Commentary)
265	Disease/ Diagnostics
3	Expression
6	General Information
1	General Stability
6	IC50 Value
57	Inhibitors
7	kcat/KM [mM/s]
52	KM Value [mM]
15	Localization
1	Metals/Ions
18	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
51	Organism
13	PDB ID
15	pH Optimum
4	pH Range
1	Posttranslational Modification
13	Protein Variants
12	Purification (Commentary)
3	Reaction
1	Reaction Type
51	Reference
56	Source Tissue
9	Specific Activity [micromol/min/mg]
130	Substrates and Products (Substrate)
13	Subunits
44	Synonyms
4	Temperature Optimum [°C]
3	Temperature Stability [°C]
7	Turnover Number [1/s]

Expression

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Expression on EC 3.4.22.40 - bleomycin hydrolase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

bleomycin hydrolase expression is up-regulated via IRF-1/2, MZF-1 and Sp-1. mRNA is up-regulated in keratinocytes when cultured at high calcium concentration (6.8fold)

Homo sapiens

-

717865

interferon-gamma significantly reduces the expression of bleomycin hydrolase. The enzyme activity and expression are markedly decreased in atopic dermatitis lesional and non-lesional skin (to 27.1 and 8.8%, respectively)

Homo sapiens

-

717865

interleukin-4 does not show any direct effect on bleomycin hydrolase expression

Homo sapiens

-

717865