3.4.22.40: bleomycin hydrolase

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For detailed information about bleomycin hydrolase, go to the full flat file.

Reaction

Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred =

Synonyms

aminopeptidase C, aminopeptidase H, ApsC, BANA-hydrolase, BH, BH protein, Bleomycin hydrolase, BLH, Blh1p, BLM hydrolase, Blmh, BLMH protein, BMH, citrulline aminopeptidase, Gal6p, Hcy-thiolactonase, homocysteine thiolactonase, HTLase, hydrolase H, More, PEPC, yBLH, yeast cysteine protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.40 bleomycin hydrolase

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Results	in table
4	Activating Compound
2648	AA Sequence
9	Application
1	CAS Registry Number
18	Cloned(Commentary)
3	Crystallization (Commentary)
265	Disease/ Diagnostics
3	Expression
6	General Information
1	General Stability
6	IC50 Value
57	Inhibitors
7	kcat/KM [mM/s]
52	KM Value [mM]
15	Localization
1	Metals/Ions
18	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
51	Organism
13	PDB ID
15	pH Optimum
4	pH Range
1	Posttranslational Modification
13	Protein Variants
12	Purification (Commentary)
3	Reaction
1	Reaction Type
51	Reference
56	Source Tissue
9	Specific Activity [micromol/min/mg]
130	Substrates and Products (Substrate)
13	Subunits
44	Synonyms
4	Temperature Optimum [°C]
3	Temperature Stability [°C]
7	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.4.22.40 - bleomycin hydrolase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

dithiothreitol

Oryctolagus cuniculus

-

activates

36726

galactose

Saccharomyces cerevisiae

Q01532

transcripton regulator

36722

Nucleic acids

Saccharomyces cerevisiae

-

RNA, single-stranded DNA or nicked DNA are bound

36715

-

additional information

Rattus norvegicus

-

binding to nucleic acids, preferably single-stranded DNA or RNA, is required for enzyme activity

668771

-