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3.4.22.39: adenain

This is an abbreviated version!
For detailed information about adenain, go to the full flat file.

Word Map on EC 3.4.22.39

Reaction

Cleaves proteins of the adenovirus and its host cell at two consensus sites: -Yaa-Xaa-Gly-Gly-/-Xaa- and -Yaa-Xaa-Gly-Xaa-/-Gly- (in which Yaa is Met, Ile or Leu, and Xaa is any amino acid) =

Synonyms

Ad L3 23K proteinase, adenain 5, adenain 8, adenoviral protease, adenovirus endopeptidase, adenovirus proteinase, adenovirus type 2 protease, AVP, AVP5, AVP8, cysteine endopeptidase, cysteine endoprotease, cysteine peptidase, cysteine protease, cysteine proteinase, endoprotease, L-cysteine proteinase, L3, L3/p23, Late L3 23 kDa protein, mercapto proteinase, oryzain, p23, papain-like cysteine protease, sulfhydryl esterase, sulfhydryl protease, sulfhydryl proteinase, thiol endopeptidase, thiol endoproteinase, thiol protease, thiol proteinase, thioprotease, trigger peptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.39 adenain

Inhibitors

Inhibitors on EC 3.4.22.39 - adenain

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2S)-2-(3,5-dichlorophenyl)-N-[(3S)-1-[2-[(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)amino]-2-oxoethyl]-2-oxopyrrolidin-3-yl]butanamide
-
-
2,2'-(hydroxynitrosohydrazono)bis-ethaneamine
-
NO generated from 2,2'-(hydroxynitrosohydrazono)bis-ethaneamine inhibits
3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxy-N-(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)benzamide
-
-
4,4-dithiodipyridine
-
-
glutamic acid
-
inhibition by displacement of viral DNA from complexes with enzyme
L-trans-epoxy-succinyl-leucylamido-(4-guanidino)-butane
-
-
L-trans-epoxy-succinyl-leucylamido-(4-guanidino)-butane-tyrosine
-
-
N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
-
-
N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide
-
-
N-[(2S)-2-(3,5-dichlorophenyl)-2-(ethylamino)acetyl]-3-methyl-L-valylglycyl-N-[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]glycinamide
-
-
N-[(2S)-2-(3-chlorophenyl)-2-[(methylsulfonyl)amino]acetyl]-L-phenylalanyl-N-(cyanomethyl)glycinamide
-
-
N-[(3,5-dichlorophenyl)acetyl]-3-methyl-L-valylglycyl-N-[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]glycinamide
-
-
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[(3,5-dichlorophenyl)acetyl]-4-methoxybenzamide
-
-
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
-
-
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide
-
-
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)propanoyl]-4-methoxybenzamide
-
-
N-[4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl]-1,3-propanediamine
-
NO generated from N-[4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl]-1,3-propanediamine inhibits the enzyme
NaCl
-
inhibition by displacement of viral DNA from complexes with enzyme
NO
-
inhibits adenovirus replication by targeting the adenovirus proteinase, inhibition is reversible with dithiothreitol
p-chloromercuribenzoate
-
-
Phenylmethylsulfonylfluoride
-
-
Soybean trypsin inhibitor
-
-
-
tosyl-lysinechloromethyl ketone
-
-
tosylamide phenylethylchloromethyl ketone
-
-