3.4.22.39: adenain

This is an abbreviated version!
For detailed information about adenain, go to the full flat file.

Word Map on EC 3.4.22.39

3.4.22.39

cathepsins

proteinases

cystatins

lysosomal

leupeptin

leishmania

calpains

trypanosoma

entamoeba

stefins

gelatin

cruzi

l-like

histolytica

kininogens

fasciola

polyproteins

pepstatin

cruzipain

gingivalis

antipain

ficin

azocasein

porphyromonas

mexicana

bromelain

vaginalis

osteoclast

propeptide

endopeptidases

actinidin

trichomonad

speb

papaya

hepatica

clostripain

chymopapain

metacercariae

amebic

medicine

weevil

mungo

amebiasis

asparaginyl

calpastatin

pineapple

procathepsin

carica

fasciolosis

gingipains

legumains

Reaction

Cleaves proteins of the adenovirus and its host cell at two consensus sites: -Yaa-Xaa-Gly-Gly-/-Xaa- and -Yaa-Xaa-Gly-Xaa-/-Gly- (in which Yaa is Met, Ile or Leu, and Xaa is any amino acid) =

Synonyms

Ad L3 23K proteinase, adenain 5, adenain 8, adenoviral protease, adenovirus endopeptidase, adenovirus proteinase, adenovirus type 2 protease, AVP, AVP5, AVP8, cysteine endopeptidase, cysteine endoprotease, cysteine peptidase, cysteine protease, cysteine proteinase, endoprotease, L-cysteine proteinase, L3, L3/p23, Late L3 23 kDa protein, mercapto proteinase, oryzain, p23, papain-like cysteine protease, sulfhydryl esterase, sulfhydryl protease, sulfhydryl proteinase, thiol endopeptidase, thiol endoproteinase, thiol protease, thiol proteinase, thioprotease, trigger peptidase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.39 adenain

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Results	in table
34	Activating Compound
353	AA Sequence
2	Application
1	CAS Registry Number
10	Cloned(Commentary)
4	Crystallization (Commentary)
19	IC50 Value
41	Inhibitors
3	Ki Value [mM]
12	KM Value [mM]
2	Localization
5	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
33	Organism
7	PDB ID
1	pH Optimum
1	pH Range
1	Protein Variants
7	Purification (Commentary)
8	Reaction
1	Reaction Type
32	Reference
1	Source Tissue
1	Specific Activity [micromol/min/mg]
36	Substrates and Products (Substrate)
4	Subunits
39	Synonyms
7	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.22.39 - adenain

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0.000002 - 0.000004

(2S)-2-(3,5-dichlorophenyl)-N-[(3S)-1-[2-[(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)amino]-2-oxoethyl]-2-oxopyrrolidin-3-yl]butanamide

2 entries

0.000001

3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxy-N-(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)benzamide

2 entries

0.0000002 - 0.0000006

N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide

2 entries

0.0000001

N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide

2 entries

0.000001

N-[(2S)-2-(3,5-dichlorophenyl)-2-(ethylamino)acetyl]-3-methyl-L-valylglycyl-N-[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]glycinamide

Human adenovirus sp.

IC50 below 0.000001 mM, isoform AVP8, pH and temperature not specified in the publication

731464

0.00001

N-[(3,5-dichlorophenyl)acetyl]-3-methyl-L-valylglycyl-N-[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]glycinamide

2 entries

0.0011 - 0.00274

N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[(3,5-dichlorophenyl)acetyl]-4-methoxybenzamide

2 entries

0.00003 - 0.00004

N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide

2 entries

0.000007 - 0.00001

N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide

2 entries

0.00031 - 0.00095

N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)propanoyl]-4-methoxybenzamide

2 entries