3.4.22.36: caspase-1

This is an abbreviated version!
For detailed information about caspase-1, go to the full flat file.

Reaction

Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-/- =

Synonyms

apoptosis-related cysteine protease, C14.001, CASP-1, Casp1, caspase 1, caspase-1, Csp-1, cysteine aspartyl protease-1, effector caspase, H.a.CASP1, hearm caspase-1, ICE, IL-1 beta converting enzyme, IL-1 converting enzyme, IL-1-converting enzyme, IL-1B converting enzyme, IL-1BC, IL-1beta-converting enzyme, IL-1beta�-converting enzyme, IL1beta-converting enzyme, interleukin 1, beta, convertase, interleukin converting enzyme, interleukin-1 beta converting enzyme, interleukin-1 converting enzyme, interleukin-1-converting enzyme, interleukin-1B converting enzyme, interleukin-1beta converting enzyme, interleukin-1beta-converting enzyme, interleukin-converting enzyme, p45, procaspase-1

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.36 caspase-1

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Results	in table
52	Activating Compound
27	AA Sequence
2	Application
1	CAS Registry Number
32	Cloned(Commentary)
4	Crystallization (Commentary)
5816	Disease/ Diagnostics
9	Expression
27	General Information
64	IC50 Value
239	Inhibitors
82	Ki Value [mM]
16	KM Value [mM]
13	Localization
2	Metals/Ions
14	Molecular Weight [Da]
166	Natural Substrates/ Products (Substrates)
764	Organism
91	PDB ID
4	pH Optimum
17	Posttranslational Modification
55	Protein Variants
8	Purification (Commentary)
1	Reaction
1	Reaction Type
152	Reference
2	Renatured (Commentary)
143	Source Tissue
1	Specific Activity [micromol/min/mg]
295	Substrates and Products (Substrate)
13	Subunits
66	Synonyms
3	Temperature Optimum [°C]
8	Turnover Number [1/s]

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.41

4-[[4'-(dimethylamino)phenyl]azo]-benzoic acid-YVADAPV-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid

Homo sapiens

P29466

pH 7.5

647635

13

acetyl-WEHD-7-amido-4-methylcoumarin

Homo sapiens

-

pH 7.5

647424

1

acetyl-YVAD-7-amido-4-methylcoumarin

Homo sapiens

P29466

pH 7.5

647635

1.2

pro-interleukin-1beta

Homo sapiens

P29466

pH 7.5

647635

-

1 - 1.6

succinyl-YVAD-4-nitroanilide

2 entries

0.35

succinyl-YVAD-7-amido-4-methylcoumarin

Homo sapiens

-

pH 7.5, 37°C

647724

additional information

additional information

Homo sapiens

-

-

647471

-

1

succinyl-YVAD-4-nitroanilide

Homo sapiens

-

pH 7.5, 37°C

647724

1.6

succinyl-YVAD-4-nitroanilide

Homo sapiens

P29466

pH 7.5

647635