3.4.22.36: caspase-1

This is an abbreviated version!
For detailed information about caspase-1, go to the full flat file.

Reaction

Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-/- =

Synonyms

apoptosis-related cysteine protease, C14.001, CASP-1, Casp1, caspase 1, caspase-1, Csp-1, cysteine aspartyl protease-1, effector caspase, H.a.CASP1, hearm caspase-1, ICE, IL-1 beta converting enzyme, IL-1 converting enzyme, IL-1-converting enzyme, IL-1B converting enzyme, IL-1BC, IL-1beta-converting enzyme, IL-1beta�-converting enzyme, IL1beta-converting enzyme, interleukin 1, beta, convertase, interleukin converting enzyme, interleukin-1 beta converting enzyme, interleukin-1 converting enzyme, interleukin-1-converting enzyme, interleukin-1B converting enzyme, interleukin-1beta converting enzyme, interleukin-1beta-converting enzyme, interleukin-converting enzyme, p45, procaspase-1

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.36 caspase-1

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
52	Activating Compound
27	AA Sequence
2	Application
1	CAS Registry Number
32	Cloned(Commentary)
4	Crystallization (Commentary)
5816	Disease/ Diagnostics
9	Expression
27	General Information
64	IC50 Value
239	Inhibitors
82	Ki Value [mM]
16	KM Value [mM]
13	Localization
2	Metals/Ions
14	Molecular Weight [Da]
166	Natural Substrates/ Products (Substrates)
764	Organism
91	PDB ID
4	pH Optimum
17	Posttranslational Modification
55	Protein Variants
8	Purification (Commentary)
1	Reaction
1	Reaction Type
152	Reference
2	Renatured (Commentary)
143	Source Tissue
1	Specific Activity [micromol/min/mg]
295	Substrates and Products (Substrate)
13	Subunits
66	Synonyms
3	Temperature Optimum [°C]
8	Turnover Number [1/s]

Purification

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Purification on EC 3.4.22.36 - caspase-1

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Purification (commentary) Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Homo sapiens

-

709475, 709953

HiTrap FF column chromatography

Homo sapiens

-

709224

HiTrap Ni-NTA column chromatography and Superdex 200 gel filtration

Homo sapiens

P29466

732127

recombinant caspase-1 solubilized from insoluble inclusion bodies from Escherichi coli by cation exchange chromatography

Homo sapiens

-

699547

recombinant enzyme

Homo sapiens

-

647424

recombinant His-tagged enzyme by metal affinity chromatography

Trichoplusia ni

B6EEC1

698280

recombinant T7-tagged enzyme

Homo sapiens

-

647724