3.4.22.36: caspase-1

This is an abbreviated version!
For detailed information about caspase-1, go to the full flat file.

Word Map on EC 3.4.22.36

3.4.22.36

inflammasome

pyroptosis

pyrin

caspases

nod-like

lps

necrosis

tnf

apoptosis-associated

speck-like

lipopolysaccharide

adaptor

pro-il-1

toll-like

card

domain-containing

nucleotide-binding

neuroinflammation

autoinflammatory

lps-induced

bcl-2

domain-like

thp-1

multiprotein

tunel

microglia

gasdermin

danger

marrow-derived

interleukin-18

leucine-rich

cpp32

urate

nod2

damage-associated

nigericin

medicine

txnip

il-1ra

bmdms

pan-caspase

hmgb1

gouty

lymphopoietin

monosodium

fas-mediated

z-vad-fmk

fas-associated

caspase-3-like

pathogen-associated

z-devd-fmk

Reaction

Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-/- =

Synonyms

apoptosis-related cysteine protease, C14.001, CASP-1, Casp1, caspase 1, caspase-1, Csp-1, cysteine aspartyl protease-1, effector caspase, H.a.CASP1, hearm caspase-1, ICE, IL-1 beta converting enzyme, IL-1 converting enzyme, IL-1-converting enzyme, IL-1B converting enzyme, IL-1BC, IL-1beta-converting enzyme, IL-1beta�-converting enzyme, IL1beta-converting enzyme, interleukin 1, beta, convertase, interleukin converting enzyme, interleukin-1 beta converting enzyme, interleukin-1 converting enzyme, interleukin-1-converting enzyme, interleukin-1B converting enzyme, interleukin-1beta converting enzyme, interleukin-1beta-converting enzyme, interleukin-converting enzyme, p45, procaspase-1

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.36 caspase-1

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Results	in table
52	Activating Compound
27	AA Sequence
2	Application
1	CAS Registry Number
32	Cloned(Commentary)
4	Crystallization (Commentary)
5816	Disease/ Diagnostics
9	Expression
27	General Information
64	IC50 Value
239	Inhibitors
82	Ki Value [mM]
16	KM Value [mM]
13	Localization
2	Metals/Ions
14	Molecular Weight [Da]
166	Natural Substrates/ Products (Substrates)
764	Organism
91	PDB ID
4	pH Optimum
17	Posttranslational Modification
55	Protein Variants
8	Purification (Commentary)
1	Reaction
1	Reaction Type
152	Reference
2	Renatured (Commentary)
143	Source Tissue
1	Specific Activity [micromol/min/mg]
295	Substrates and Products (Substrate)
13	Subunits
66	Synonyms
3	Temperature Optimum [°C]
8	Turnover Number [1/s]

Molecular Weight

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of the Enzyme Summary Page.

Molecular Weight on EC 3.4.22.36 - caspase-1

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10000

Mus musculus

x * 10000, autocatalytically activated subunit of caspase-1, SDS-PAGE

732262

10244

Homo sapiens

P29466

1 * 19844 + 1 * 10244, calculated from amino acid sequence

17000

x * 17000, SDS-PAGE

19000

x * 35000, about, pro-enzyme, SDS-PAGE, x * 23000, about, processed enzyme form 1, SDS-PAGE, x * 19000, about, processed enzyme form 2, SDS-PAGE

698280

19844

Homo sapiens

P29466

1 * 19844 + 1 * 10244, calculated from amino acid sequence

731897

23000

Trichoplusia ni

B6EEC1

x * 35000, about, pro-enzyme, SDS-PAGE, x * 23000, about, processed enzyme form 1, SDS-PAGE, x * 19000, about, processed enzyme form 2, SDS-PAGE

698280

27500

Lymantria dispar

1 * 27500 + 1 * 8700, SDS-PAGE

732287

33304

Lymantria dispar

x * 33304, calculated from amino acid sequence

732287

35000

Trichoplusia ni

B6EEC1

x * 35000, about, pro-enzyme, SDS-PAGE, x * 23000, about, processed enzyme form 1, SDS-PAGE, x * 19000, about, processed enzyme form 2, SDS-PAGE

698280

45000

4 entries

8700

Lymantria dispar

1 * 27500 + 1 * 8700, SDS-PAGE

732287