3.4.22.36: caspase-1

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For detailed information about caspase-1, go to the full flat file.

Reaction

Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-/- =

Synonyms

apoptosis-related cysteine protease, C14.001, CASP-1, Casp1, caspase 1, caspase-1, Csp-1, cysteine aspartyl protease-1, effector caspase, H.a.CASP1, hearm caspase-1, ICE, IL-1 beta converting enzyme, IL-1 converting enzyme, IL-1-converting enzyme, IL-1B converting enzyme, IL-1BC, IL-1beta-converting enzyme, IL-1beta�-converting enzyme, IL1beta-converting enzyme, interleukin 1, beta, convertase, interleukin converting enzyme, interleukin-1 beta converting enzyme, interleukin-1 converting enzyme, interleukin-1-converting enzyme, interleukin-1B converting enzyme, interleukin-1beta converting enzyme, interleukin-1beta-converting enzyme, interleukin-converting enzyme, p45, procaspase-1

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.36 caspase-1

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Results	in table
52	Activating Compound
27	AA Sequence
2	Application
1	CAS Registry Number
32	Cloned(Commentary)
4	Crystallization (Commentary)
5816	Disease/ Diagnostics
9	Expression
27	General Information
64	IC50 Value
239	Inhibitors
82	Ki Value [mM]
16	KM Value [mM]
13	Localization
2	Metals/Ions
14	Molecular Weight [Da]
166	Natural Substrates/ Products (Substrates)
764	Organism
91	PDB ID
4	pH Optimum
17	Posttranslational Modification
55	Protein Variants
8	Purification (Commentary)
1	Reaction
1	Reaction Type
152	Reference
2	Renatured (Commentary)
143	Source Tissue
1	Specific Activity [micromol/min/mg]
295	Substrates and Products (Substrate)
13	Subunits
66	Synonyms
3	Temperature Optimum [°C]
8	Turnover Number [1/s]

Expression

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Expression on EC 3.4.22.36 - caspase-1

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

an approximately 32fold increase in caspase-1 expression is observed in the p53-knockin cell line H273

Homo sapiens

P29466

709488

caspase 1 activity is inhibited in mice lacking active cysteine proteases

Mus musculus

-

707322

caspase-1 is activated as a consequence of Helicobacter infection

Mus musculus

-

732262

caspase-1 is upregulated in CD8+ cells with decreased expression of interleukin-4 and interleukin-10

Mus musculus

-

709269

interferon-beta is not required for the activation of caspase-1

Mus musculus

-

708709

macrophages from A/J mice exhibit reduced caspase-1 activation and IL-1beta secretion compared to C57BL/6 macrophages

Mus musculus

-

718077

the activation of caspase-1 is markedly inhibited with increasing concentrations of extracellular KCl

Mus musculus

-

708709

the region of difference 1 locus in the Mycobacterium tuberculosis genome contributes to activation of caspase-1 via induction of potassium ion efflux in infected macrophages

Mus musculus

-

708709

the transcript of caspase-1 and its protein products appear in two or more waves in the midgut during metamorphosis

Galleria mellonella

F8UU16

731922