3.4.22.34: Legumain
This is an abbreviated version!
For detailed information about Legumain, go to the full flat file.
Word Map on EC 3.4.22.34
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3.4.22.34
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cathepsins
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phaseolus
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vulgaris
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vacuole
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cystatins
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proteinases
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metastasis
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papain
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cotyledon
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plasmodium
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globulin
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falciparum
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vicilins
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schistosoma
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papain-like
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tau
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legume
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endopeptidases
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seed-specific
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mesoamerican
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phytohemagglutinin
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falcipain-2
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clan
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mansoni
-
andean
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leguminous
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procathepsins
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lunatus
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cyclotides
-
jack
-
caspase-1-like
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drug development
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biotechnology
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medicine
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diagnostics
- 3.4.22.34
- cathepsins
- phaseolus
- vulgaris
- vacuole
- cystatins
- proteinases
- metastasis
- papain
- cotyledon
- plasmodium
- globulin
- falciparum
- vicilins
- schistosoma
-
papain-like
- tau
-
legume
- endopeptidases
-
seed-specific
-
mesoamerican
- phytohemagglutinin
- falcipain-2
-
clan
- mansoni
-
andean
-
leguminous
-
procathepsins
- lunatus
-
cyclotides
-
jack
-
caspase-1-like
- drug development
- biotechnology
- medicine
- diagnostics
Reaction
hydrolysis of proteins and small molecule substrates at -Asn-/-Xaa- bonds =
Synonyms
AEP, Antigen Sj32, Antigen SM32, As-specific vacuolar cysteine proteinase, Asn-specific vacuolar cysteine proteinase, asparagine endopeptidase, asparaginly endopeptidase, asparaginyl endopepidase, Asparaginyl endopeptidase, asparaginyl endopeptidase legumain, asparaginyl endopeptidase,, asparaginyl proteinase, asparaginyl-specific cysteine endopeptidase, asparagyl-endopeptidase, aspartate-specific endopeptidase, AtLEGgamma, Bean endopeptidase, C197 legumain, c197 Sm32, cysteine protease 1, hemoglobinase, HlLgm, HlLgm2, IrAE, IrAE protein, isae1, isae2, LeG, LEG-1, Leg-2, Leg-4, Leg1, Leg2, Leg3, Leg4, Leg5, legumain, legumain-1, LGMN, lysosomal asparaginycysteine endopeptidase, lysosomal asparaginyl endopeptidase, lysosomal cysteine proteinase, More, N197 legumain, osteoclast inhibitory peptide 2, Ov-aep-1, Phaseolin, Proteinase B, PrVPE1, schistosome legumain, Sj32, Sm32, SmAE, SmAE protein, SPAE, TcLEG3, TcLEG6, TcLEG9, TvAE1, vacuolar processing enzyme, vacuolar processing enzyme 1a, vacuolar processing enzyme 1b, vacuolar processing enzyme 2, vacuolar processing enzyme 3, Vicilin peptidohydrolase, VPE, VPE1a, VPE1b, VPE2, VPE3
ECTree
3.4.22.34 LegumainAdvanced search results
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Reference on EC 3.4.22.34 - Legumain
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Baumgartner, B.; Chrispeels, M.J.
Purification and characterization of vicilin peptidohydrolase, the major endopeptidase in the cotyledons of mung-bean seedlings
Eur. J. Biochem.
77
223-233
1977
Vigna radiata
Csoma, C.; Polgar, L.
Proteinase from germinating bean cotyledons. Evidence for involvement of a thiol group in catalysis
Biochem. J.
222
769-776
1984
Phaseolus vulgaris
Ishii, S.I.
Legumain: asparaginyl endopeptidase
Methods Enzymol.
244
604-615
1994
Canavalia ensiformis
Abe, Y.; Shirane, K.; Yokosawa, H.; Matsushita, H.; Mitta, M.; Kato, I.; Ishii, S.
Asparaginyl endopeptidase of jack bean seeds. Purification, characterization, and high utility in protein sequence analysis
J. Biol. Chem.
268
3525-3529
1993
Canavalia ensiformis
Takeda, O.; Miura, Y.; Mitta, M.; Matsushita, H.; Kato, I.; Abe, Y.; Yokosawa, H.; Ishii, S.
Isolation and analysis of cDNA encoding a precursor of Canavalia ensiformis asparaginyl endopeptidase (legumain)
J. Biochem.
116
541-546
1994
Canavalia ensiformis
Kembhavi, A.A.; Buttle, D.J.; Knight, C.G.; Barrett, A.J.
The two cysteine endopeptidases of legume seeds: purification and characterization by use of specific fluorometric assays
Arch. Biochem. Biophys.
303
208-213
1993
Vigna aconitifolia
Scott, M.P.; Jung, R.; Muntz, K.; Nielsen, N.C.
A protease responsible for post-translational cleavage of a conserved Asn-Gly linkage in glycinin, the major seed storage protein of soybean
Proc. Natl. Acad. Sci. USA
89
658-662
1992
Glycine max
Hara-Nishimura, I.; Inoue, K.; Nishimura, M.
A unique vacuolar processing enzyme responsible for conversion of several proprotein precursors into the mature forms
FEBS Lett.
294
89-93
1991
Ricinus communis
Dando, P.M.; Fortunato, M.; Smith, L.; Knight, C.G.; McKendrick, J.E.; Barrett, A.J.
Pig kidney legumain: an asparaginyl endopeptidase with restricted
Biochem. J.
339
743-749
1999
Sus scrofa
-
Yamane, T.; Takeuchi, K.; Yamamoto, Y.; Li, Y.H.; Fujiwara, M.; Nishi, K.; Takahashi, S.; Ohkubo, I.
Legumain from bovine kidney: its purification, molecular clonin, immunohistochemical localization and degradation of annexin II and vitamin D-binding protein
Biochim. Biophys. Acta
1596
108-120
2002
Bos taurus (Q95M12), Bos taurus
Chen, J.M.; Fortunato, M.; Stevens, R.A.E.; Barrett, A.J.
Activation of progelatinase A by mammalian lugumain, a recently discovered cysteine proteinase
Biol. Chem.
382
777-783
2001
Homo sapiens, Sus scrofa
Rotari, V.I.; Dando, P.M.; Barrett, A.J.
Legumain forms from plants and animals differ in their specificity
Biol. Chem.
382
953-959
2001
Phaseolus vulgaris, Sus scrofa
Niestroj, A.J.; Feußner, K.; Heiser, U.; Dando, P.M.; Barrett, A.J.; Gerhartz, B.; Demuth, H.U.
Inhibition of mammalian legumain by Michael acceptors and AzaAsn-halomethylketones
Biol. Chem.
383
1205-1214
2002
Sus scrofa
Schwarz, G.; Brandenburg, J.; Reich, M.; Burster T.; Driessen, C.; Kalbacher, H.
Characterization of legumain
Biol. Chem.
383
1813-1816
2002
Sus scrofa
Loak, K.; Li, D.N.; Manoury, B.; Billson, J.; Morton, F.; Hewitt, E.; Watts, C.
Novel cell-permeable acyloxymethylketone inhibitors of asparaginyl endopeptidase
Biol. Chem.
384
1239-1246
2003
Homo sapiens
Senyuk, V.; Rotari, V.; Becker, C.; Zakharov, A.; Hortmann, C.; Müntz, K.; Vaintraub, I.
Does an asparaginyl-specific cysteine endopeptidase trigger phaseolin degradation in cotyledons of kidney bean seedlings ?
Eur. J. Biochem.
258
546-558
1998
Phaseolus vulgaris (O24325), Phaseolus vulgaris
Halfon, S.; Patel, S.; Vega, F.; Zurawski, S.; Zurawski, G.
Autocatalytic activation of human legumain at aspartic acid residues
FEBS Lett.
438
114-118
1998
Homo sapiens, Mus musculus (O89017), Mus musculus
Chen, J.M.; Rawlings, N.D.; Stevens, R.A.E.; Barrett, A.J.
Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of endopeptidases
FEBS Lett.
441
361-365
1998
Mus musculus
Chen, J.M.; Dando, P.M.; Rawlings, N.D.; Brown, M.A.; Young, N.E.; Stevens, R.A.; Hewitt, E.; Watts, C.; Barrett, A.J.
Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase
J. Biol. Chem.
272
8090-8098
1997
Sus scrofa, Homo sapiens (Q99538), Homo sapiens
Alvarez-Fernandez, M.; Barrett, A.J.; Gerhartz, B.; Dando, P.M.; Ni, J.; Abrahamson, M.
Inhibition of mammalian legumain by some cystatins is due too a novel second reactive site
J. Biol. Chem.
274
19195-19203
1999
Sus scrofa
Choi, S.J.; Reddy, S.V.; Devlin, R.D.; Menaa, C.; Chung, H.; Boyce, B.B.; Roodman, G.D.
Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption
J. Biol. Chem.
274
27747-27753
1999
Homo sapiens (Q99538), Homo sapiens
Mathieu, M.A.; Bogyo, M.; Caffrey, C.R.; Choe, Y.; Lee, J.; Chapman, H.; Sajid, M.; Craik, C.S.; McKerrow, J.H.
Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries
Mol. Biochem. Parasitol.
121
99-105
2002
Homo sapiens, Schistosoma mansoni
Müntz, K.; Shutov, A.D.
Legumains and their functions in plants
Trends Plant Sci.
2
1360-1385
2002
Arabidopsis thaliana, Canavalia ensiformis, Ricinus communis, Vicia sativa, Nicotiana tabacum (Q9XG75)
-
Murthy, R.V.; Arbman, G.; Gao, J.; Roodman, G.D.; Sun, X.F.
Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer
Clin. Cancer Res.
11
2293-2299
2005
Homo sapiens
Wolk, K.; Gruetz, G.; Witte, K.; Volk, H.D.; Sabat, R.
The expression of legumain, an asparaginyl endopeptidase that controls antigen processing, is reduced in endotoxin-tolerant monocytes
Genes Immun.
6
452-456
2005
Homo sapiens
Chen, J.; Dando, P.M.; Barrett, A.J.
Mammalian legumain
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press
2
1302-1305
2004
Homo sapiens, Mus musculus, Sus scrofa
-
Brindley, P.J.; Dalton, J.P.
Schistosome legumain
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press
2
1305-1310
2004
Schistosoma mansoni (P09841), Schistosoma mansoni (Q9NFY9), Schistosoma japonicum (P42665), Homo sapiens (Q99538)
-
Hara-Nishimura, I.
Plant legumain, asparaginyl endopeptidase
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press
2
1310-1313
2004
Arabidopsis thaliana, Canavalia ensiformis, Ricinus communis, Glycine max, Vigna mungo, Phaseolus vulgaris, Vigna aconitifolia
-
Zakharov, A.; Muentz, K.
Seed legumains are expressed in stamens and vegetative legumains in seeds of Nicotiana tabacum L
J. Exp. Bot.
55
1593-1595
2004
Nicotiana tabacum (Q707T9), Nicotiana tabacum (Q852T0), Nicotiana tabacum (Q852T1), Nicotiana tabacum (Q852T2), Nicotiana tabacum (Q852T3), Nicotiana tabacum (Q9XG75), Nicotiana tabacum (Q9XG76), Nicotiana tabacum
Chen, H.J.; Hou, W.C.; Liu, J.S.; Yang, C.Y.; Huang, D.J.; Lin, Y.H.
Molecular cloning and characterization of a cDNA encoding asparaginyl endopeptidase from sweet potato (Ipomoea batatas (L.) Lam) senescent leaves
J. Exp. Bot.
55
825-835
2004
Ipomoea batatas (Q9M4R6), Ipomoea batatas
Maehr, R.; Hang, H.C.; Mintern, J.D.; Kim, Y.M.; Cuvillier, A.; Nishimura, M.; Yamada, K.; Shirahama-Noda, K.; Hara-Nishimura, I.; Ploegh, H.L.
Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice
J. Immunol.
174
7066-7074
2005
Mus musculus
Vigneswaran, N.; Wu, J.; Nagaraj, N.; James, R.; Zeeuwen, P.; Zacharias, W.
Silencing of cystatin M in metastatic oral cancer cell line MDA-686Ln by siRNA increases cysteine proteinases and legumain activities, cell proliferation and in vitro invasion
Life Sci.
78
898-907
2006
Homo sapiens
Oliver, E.M.; Skuce, P.J.; McNair, C.M.; Knox, D.P.
Identification and characterization of an asparaginyl proteinase (legumain) from the parasitic nematode, Haemonchus contortus
Parasitology
133
237-244
2006
Haemonchus contortus (Q2UVF3), Haemonchus contortus
Martinez, M.; Diaz-Mendoza, M.; Carrillo, L.; Diaz, I.
Carboxy terminal extended phytocystatins are bifunctional inhibitors of papain and legumain cysteine proteinases
FEBS Lett.
581
2914-2918
2007
Hordeum vulgare, Homo sapiens (Q99538), Homo sapiens
Clerin, V.; Shih, H.H.; Deng, N.; Hebert, G.; Resmini, C.; Shields, K.M.; Feldman, J.L.; Winkler, A.; Albert, L.; Maganti, V.; Wong, A.; Paulsen, J.E.; Keith, J.C.; Vlasuk, G.P.; Pittman, D.D.
Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis
Atherosclerosis
201
53-66
2008
Mus musculus (O89017), Mus musculus, Homo sapiens (Q99538), Homo sapiens
Sexton, K.B.; Witte, M.D.; Blum, G.; Bogyo, M.
Design of cell-permeable, fluorescent activity-based probes for the lysosomal cysteine protease asparaginyl endopeptidase (AEP)/legumain
Bioorg. Med. Chem. Lett.
17
649-653
2007
Homo sapiens (Q99538), Homo sapiens
Morita, Y.; Araki, H.; Sugimoto, T.; Takeuchi, K.; Yamane, T.; Maeda, T.; Yamamoto, Y.; Nishi, K.; Asano, M.; Shirahama-Noda, K.; Nishimura, M.; Uzu, T.; Hara-Nishimura, I.; Koya, D.; Kashiwagi, A.; Ohkubo, I.
Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells. [Erratum to document cited in CA146:460121]
FEBS Lett.
581
3579
2007
Mus musculus (O89017), Mus musculus
Jackson, M.A.; Rae, A.L.; Casu, R.E.; Grof, C.P.; Bonnett, G.D.; Maclean, D.J.
A bioinformatic approach to the identification of a conserved domain in a sugarcane legumain that directs GFP to the lytic vacuole
Funct. Plant Biol.
34
633-644
2007
Saccharum officinarum (Q0ZHB0)
Abdul Alim, M.; Tsuji, N.; Miyoshi, T.; Khyrul Islam, M.; Huang, X.; Motobu, M.; Fujisaki, K.
Characterization of asparaginyl endopeptidase, legumain induced by blood feeding in the ixodid tick Haemaphysalis longicornis
Insect Biochem. Mol. Biol.
37
911-922
2007
Haemaphysalis longicornis (A4PF00), Haemaphysalis longicornis, Haemaphysalis longicornis Okayama (A4PF00)
Sojka, D.; Hajdusek, O.; Dvorak, J.; Sajid, M.; Franta, Z.; Schneider, E.L.; Craik, C.S.; Vancova, M.; Buresova, V.; Bogyo, M.; Sexton, K.B.; McKerrow, J.H.; Caffrey, C.R.; Kopacek, P.
IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus
Int. J. Parasitol.
37
713-724
2007
Ixodes ricinus (Q6PRC7), Ixodes ricinus
Saska, I.; Gillon, A.D.; Hatsugai, N.; Dietzgen, R.G.; Hara-Nishimura, I.; Anderson, M.A.; Craik, D.J.
An asparaginyl endopeptidase mediates in vivo protein backbone cyclization
J. Biol. Chem.
282
29721-29728
2007
Nicotiana benthamiana, Viola tricolor, Oldenlandia affinis
Adisakwattana, P.; Viyanant, V.; Chaicumpa, W.; Vichasri-Grams, S.; Hofmann, A.; Korge, G.; Sobhon, P.; Grams, R.
Comparative molecular analysis of two asparaginyl endopeptidases and encoding genes from Fasciola gigantica
Mol. Biochem. Parasitol.
156
102-116
2007
Fasciola gigantica (A6Y9U8), Fasciola gigantica (A6Y9U9), Fasciola gigantica
Krautz-Peterson, G.; Skelly, P.J.
Schistosome asparaginyl endopeptidase (legumain) is not essential for cathepsin B1 activation in vivo
Mol. Biochem. Parasitol.
159
54-58
2008
Schistosoma mansoni (P09841), Schistosoma mansoni
Stern, L.; Perry, R.; Ofek, P.; Many, A.; Shabat, D.; Satchi-Fainaro, R.
A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain
Bioconjug. Chem.
20
500-510
2009
Homo sapiens
Laha, T.; Sripa, J.; Sripa, B.; Pearson, M.; Tribolet, L.; Kaewkes, S.; Sithithaworn, P.; Brindley, P.J.; Loukas, A.
Asparaginyl endopeptidase from the carcinogenic liver fluke, Opisthorchis viverrini, and its potential for serodiagnosis
Int. J. Infect. Dis.
12
49-59
2008
Opisthorchis viverrini (Q208S4), Opisthorchis viverrini
Alim, M.A.; Tsuji, N.; Miyoshi, T.; Islam, M.K.; Huang, X.; Hatta, T.; Fujisaki, K.
HlLgm2, a member of asparaginyl endopeptidases/legumains in the midgut of the ixodid tick Haemaphysalis longicornis, is involved in blood-meal digestion
J. Insect Physiol.
54
573-585
2008
Haemaphysalis longicornis (A9CQC1), Haemaphysalis longicornis
Goetz, M.G.; James, K.E.; Hansell, E.; Dvorak, J.; Seshaadri, A.; Sojka, D.; Kopacek, P.; McKerrow, J.H.; Caffrey, C.R.; Powers, J.C.
Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens
J. Med. Chem.
51
2816-2832
2008
Schistosoma mansoni, Ixodes ricinus, Trichomonas vaginalis (Q6EHZ7)
Alim, M.A.; Tsuji, N.; Miyoshi, T.; Islam, M.K.; Hatta, T.; Yamaji, K.; Fujisaki, K.
Developmental stage- and organ-specific expression profiles of asparaginyl endopeptidases/legumains in the ixodid tick Haemaphysalis longicornis
J. Vet. Med. Sci.
70
1363-1366
2008
Haemaphysalis longicornis
Ledgard, A.M.; Lee, R.S.; Peterson, A.J.
Bovine endometrial legumain and TIMP-2 regulation in response to presence of a conceptus
Mol. Reprod. Dev.
76
65-74
2009
Bos taurus (Q95M12), Bos taurus
Chan, C.B.; Abe, M.; Hashimoto, N.; Hao, C.; Williams, I.R.; Liu, X.; Nakao, S.; Yamamoto, A.; Li, S.Y.; Hara-Nishimura, I.; Asano, M.; Ye, K.
Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome
Proc. Natl. Acad. Sci. USA
106
468-473
2009
Mus musculus
Briggs, J.; Haugen, M.; Johansen, H.; Riker, A.; Abrahamson, M.; Fodstad, Ø.; Mælandsmo, G.; Solberg, R.
Cystatin E/M suppresses legumain activity and invasion of human melanoma
BMC Cancer
10
17
2010
Homo sapiens
Lee, J.; Bogyo, M.
Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain
Chem. Biol.
5
233-243
2010
Mus musculus
Wu, B.; Yin, J.; Texier, C.; Roussel, M.; Tan, K.S.
Blastocystis legumain is localized on the cell surface, and specific inhibition of its activity implicates a pro-survival role for the enzyme
J. Biol. Chem.
285
1790-1798
2010
Blastocystis sp. BW-2009a (C1K3M8), Blastocystis hominis (D1M8Z4)
Ovat, A.; Muindi, F.; Fagan, C.; Brouner, M.; Hansell, E.; Dvorak, J.; Sojka, D.; Kopacek, P.; McKerrow, J.H.; Caffrey, C.R.; Powers, J.C.
Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases)
J. Med. Chem.
52
7192-7210
2009
Schistosoma mansoni, Ixodes ricinus
Dall, E.; Brandstetter, H.
Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile
Acta Crystallogr. Sect. F
68
24-31
2012
Homo sapiens (Q99538)
Lee, J.; Bogyo, M.
Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain
Bioorg. Med. Chem. Lett.
22
1340-1343
2011
Homo sapiens, Mus musculus
Teng, L.; Wada, H.; Zhang, S.
Identification and functional characterization of legumain in amphioxus Branchiostoma belcheri
Biosci. Rep.
30
177-186
2010
Branchiostoma belcheri
Andrade, V.; Guerra, M.; Jardim, C.; Melo, F.; Silva, W.; Ortega, J.M.; Robert, M.; Nathanson, M.H.; Leite, F.
Nucleoplasmic calcium regulates cell proliferation through legumain
J. Hepatol.
55
626-635
2011
Homo sapiens
Bosch, M.; Poulter, N.S.; Perry, R.M.; Wilkins, K.A.; Franklin-Tong, V.E.
Characterization of a legumain/vacuolar processing enzyme and YVADase activity in Papaver pollen
Plant Mol. Biol.
74
381-393
2010
Papaver rhoeas
Dall, E.; Fegg, J.C.; Briza, P.; Brandstetter, H.
Structure and mechanism of an aspartimide-dependent peptide ligase in human legumain
Angew. Chem. Int. Ed. Engl.
54
2917-2921
2015
Homo sapiens (Q99538), Homo sapiens
Smith, R.; Johansen, H.T.; Nilsen, H.; Haugen, M.H.; Pettersen, S.J.; Maelandsmo, G.M.; Abrahamson, M.; Solberg, R.
Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M
Biochimie
94
2590-2599
2012
Homo sapiens
Solberg, R.; Smith, R.; Almloef, M.; Tewolde, E.; Nilsen, H.; Johansen, H.T.
Legumain expression, activity and secretion are increased during monocyte-to-macrophage differentiation and inhibited by atorvastatin
Biol. Chem.
396
71-80
2015
Homo sapiens
Julian, I.; Gandullo, J.; Santos-Silva, L.K.; Diaz, I.; Martinez, M.
Phylogenetically distant barley legumains have a role in both seed and vegetative tissues
J. Exp. Bot.
64
2929-2941
2013
Hordeum vulgare
Pierre, O.; Hopkins, J.; Combier, M.; Baldacci, F.; Engler, G.; Brouquisse, R.; Herouart, D.; Boncompagni, E.
Involvement of papain and legumain proteinase in the senescence process of Medicago truncatula nodules
New Phytol.
202
849-863
2014
Medicago truncatula
Santos-Silva, L.K.; Soares-Costa, A.; Gerald, L.T.; Meneghin, S.P.; Henrique-Silva, F.
Recombinant expression and biochemical characterization of sugarcane legumain
Plant Physiol. Biochem.
57
181-192
2012
Saccharum sp. (H2EUL5)
Christoff, A.P.; Turchetto-Zolet, A.C.; Margis, R.
Uncovering legumain genes in rice
Plant Sci.
215-216
100-109
2014
Oryza sativa
Hasegawa, S.; Inoue, D.; Yamasaki, M.; Li, C.; Imai, M.; Takahashi, N.; Fukui, T.
Site-specific cleavage of acetoacetyl-CoA synthetase by legumain
FEBS Lett.
590
1592-1601
2016
Mus musculus (O89017), Mus musculus
Elsaesser, B.; Zauner, F.B.; Messner, J.; Soh, W.T.; Dall, E.; Brandstetter, H.
Distinct roles of catalytic cysteine and histidine in the protease and ligase mechanisms of human legumain as revealed by DFT-based QM/MM simulations
ACS Catal.
7
5585-5593
2017
Homo sapiens (Q99538), Homo sapiens
Yamane, T.; Yamamoto, Y.; Nakano, Y.; Nakagaki, T.; Ohkubo, I.; Ariga, H.
Expression and protease activity of mouse legumain are regulated by the oncogene/transcription co-activator, DJ-1 through p53 and cleavage of annexin A2 is increased in DJ-1-knockout cells
Biochem. Biophys. Res. Commun.
467
472-477
2015
Mus musculus (O89017), Mus musculus
Dall, E.; Brandstetter, H.
Structure and function of legumain in health and disease
Biochimie
122
126-150
2016
Mammalia, unidentified plant, Schistosoma mansoni (P09841), Bos taurus (Q95M12), Homo sapiens (Q99538), Homo sapiens
Lunde, N.N.; Haugen, M.H.; Bodin Larsen, K.B.; Damgaard, I.; Pettersen, S.J.; Kasem, R.; Rut, W.; Drag, M.; Poreba, M.; Johansen, H.T.; Solberg, R.
Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions
Biochimie
139
27-37
2017
Bos taurus (Q95M12), Bos taurus
Ness, K.A.; Eddie, S.L.; Higgins, C.A.; Templeman, A.; DCosta, Z.; Gaddale, K.K.; Bouzzaoui, S.; Jordan, L.; Janssen, D.; Harrison, T.; Burkamp, F.; Young, A.; Burden, R.; Scott, C.J.; Mullan, P.B.; Williams, R.
Development of a potent and selective cell penetrant Legumain inhibitor
Bioorg. Med. Chem. Lett.
25
5642-5645
2015
Homo sapiens (Q99538)
Ness, K.A.; Eddie, S.L.; Burton, S.; Harrison, T.; Mullan, P.; Williams, R.
Flat SAR of P3-methylsulphonamide based small molecule legumain inhibitors
Bioorg. Med. Chem. Lett.
26
413-416
2016
Homo sapiens (Q99538)
Eddie, S.L.; Gregson, A.; Graham, E.; Burton, S.; Harrison, T.; Burden, R.; Scott, C.J.; Mullan, P.B.; Williams, R.
Identification and SAR exploration of a novel series of legumain inhibitors
Bioorg. Med. Chem. Lett.
29
1546-1548
2019
Homo sapiens (Q99538)
Vidmar, R.; Vizovisek, M.; Turk, D.; Turk, B.; Fonovic, M.
Protease cleavage site fingerprinting by label-free in-gel degradomics reveals pH-dependent specificity switch of legumain
EMBO J.
36
2455-2465
2017
Homo sapiens (Q99538)
Hartmann, D.; Sima, R.; Konvickova, J.; Perner, J.; Kopacek, P.; Sojka, D.
Multiple legumain isoenzymes in ticks
Int. J. Parasitol.
48
167-178
2018
Ixodes scapularis, Ixodes scapularis (A0A1S6XZC8)
Nourrisson, C.; Wawrzyniak, I.; Cian, A.; Livrelli, V.; Viscogliosi, E.; Delbac, F.; Poirier, P.
On Blastocystis secreted cysteine proteases a legumain-activated cathepsin B increases paracellular permeability of intestinal Caco-2 cell monolayers
Parasitology
143
1713-1722
2016
Blastocystis hominis (D8M176)
Holzhausen, J.; Haake, C.; Schicht, S.; Hinse, P.; Jordan, D.; Kremmer, E.; Strube, C.
Biological function of Dictyocaulus viviparus asparaginyl peptidase legumain-1 and its suitability as a vaccine target
Parasitology
145
378-392
2018
Dictyocaulus viviparus (I6R478), Dictyocaulus viviparus
Zauner, F.B.; Dall, E.; Regl, C.; Grassi, L.; Huber, C.G.; Cabrele, C.; Brandstetter, H.
Crystal structure of plant legumain reveals a unique two-chain state with pH-dependent activity regulation
Plant Cell
30
686-699
2018
Arabidopsis thaliana (Q39119), Arabidopsis thaliana
Santana, J.O.; Freire, L.; de Sousa, A.O.; Fontes Soares, V.L.; Gramacho, K.P.; Pirovani, C.P.
Characterization of the legumains encoded by the genome of Theobroma cacao L
Plant Physiol. Biochem.
98
162-170
2016
Theobroma cacao
Zhao, T.; Li, Z.; Guo, Z.; Wang, A.; Liu, Z.; Zhao, Q.; Li, Y.; McKenzie, E.A.; Diao, A.
Functional recombinant human Legumain protein expression in Pichia pastoris to enable screening for Legumain small molecule inhibitors
Protein Expr. Purif.
150
12-16
2018
Homo sapiens (Q99538), Homo sapiens
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