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3.4.22.33: Fruit bromelain

This is an abbreviated version!
For detailed information about Fruit bromelain, go to the full flat file.

Word Map on EC 3.4.22.33

Reaction

Hydrolysis of proteins with broad specificity for peptide bonds. Bz-Phe-Val-Arg-/-NHMec is a good synthetic substrate, but there is no action on Z-Arg-Arg-NHMec (c.f. stem bromelain) =

Synonyms

ACMD2_17643, Ananase, Bromelain, bromelain A, bromelain B, Bromelain, juice, Bromelase, Bromelin, EC 3.4.22.4, EC 3.4.22.5, EC 3.4.4.24, Extranase, fastuosain, FBM, Fruit bromelain, Fruit bromelain FA2, Juice bromelain, More, Pinase, Traumanase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.33 Fruit bromelain

Reference

Reference on EC 3.4.22.33 - Fruit bromelain

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Murachi, T.
Bromelain enzymes
Methods Enzymol.
19
273-284
1970
Ananas comosus
-
Manually annotated by BRENDA team
Murachi, T.
Bromelain enzymes
Methods Enzymol.
45
475-485
1976
Ananas comosus
Manually annotated by BRENDA team
Ota, S.; Horie, K.; Hagino, F.; Hashimoto, C.; Date, H.
Fractionation and some properties of the proteolytically active components of bromelains in the stem and the fruit of the pineapple plant
J. Biochem.
71
817-830
1972
Ananas comosus
Manually annotated by BRENDA team
Ota, S.; Muta, E.; Katahira, Y.; Okamoto, Y.
Reinvestigation of fractionation and some properties of the proteolytically active components of stem and fruit bromelains
J. Biochem.
98
219-228
1985
Ananas comosus
Manually annotated by BRENDA team
Rowan, A.D.; Brzin, J.; Buttle, D.J.; Barrett, A.J.
Inhibition of cysteine proteinases by a protein inhibitor from potato
FEBS Lett.
269
328-330
1990
Ananas comosus
Manually annotated by BRENDA team
Suh, H.J.; Lee, H.; Cho, H.Y.; Yang, H.C.
Purification and characterization of bromelain isolated from pineapple
Han'guk Nonghwa Hakhoechi
35
300-307
1992
Ananas comosus
-
Manually annotated by BRENDA team
Yamada, F.; Takahashi, N.; Murachi, T.
Purification and characterization of a proteinase from pineapple fruit, fruit bromelain FA2
J. Biochem.
79
1223-1234
1976
Ananas comosus
Manually annotated by BRENDA team
Sasaki, M.; Kato, T.; Iida, S.
Antigenic determinant common to four kinds of thiol proteases of plant origin
J. Biochem.
74
635-637
1973
Ananas comosus
Manually annotated by BRENDA team
Toro-Goyco, E.; Rodriguez-Costas, I.
Immunochemical studies on pinguinain. A sulfhydryl plant protease
Arch. Biochem. Biophys.
175
359-366
1976
Ananas comosus, Bromelia pinguin
Manually annotated by BRENDA team
Maurer, H.R.
Bromelain: biochemistry, pharmacology and medical use
Cell. Mol. Life Sci.
58
1234-1245
2001
Ananas comosus
Manually annotated by BRENDA team
Rowan, A.D.
Fruit bromelain
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
2
1137-1138
2004
Ananas comosus
-
Manually annotated by BRENDA team
Hale, L.P.; Greer, P.K.; Trinh, C.T.; James, C.L.
Proteinase activity and stability of natural bromelain preparations
Int. Immunopharmacol.
5
783-793
2005
Ananas comosus
Manually annotated by BRENDA team
Hemavathi, A.B.; Hebbar, H.U.; Raghavarao, K.S.
Reverse micellar extraction of bromelain from Ananas comosus L. Merryl
J. Chem. Technol. Biotechnol.
82
985-992
2007
Ananas comosus (O23791)
-
Manually annotated by BRENDA team
Cabral, H.; Leopoldino, A.M.; Tajara, E.H.; Greene, L.J.; Faca, V.M.; Mateus, R.P.; Ceron, C.R.; de Souza Judice, W.A.; Julianod, L.; Bonilla-Rodriguez, G.O.
Preliminary functional characterization, cloning and primary sequence of Fastuosain, a cysteine peptidase isolated from fruits of Bromelia fastuosa
Protein Pept. Lett.
13
83-89
2006
Bromelia fastuosa (Q6Q2T4), Bromelia fastuosa
Manually annotated by BRENDA team
Shukor, M.Y.; Masdor, N.; Baharom, N.A.; Jamal, J.A.; Abdullah, M.P.; Shamaan, N.A.; Syed, M.A.
An inhibitive determination method for heavy metals using bromelain, a cysteine protease
Appl. Biochem. Biotechnol.
144
283-291
2008
Ananas comosus
Manually annotated by BRENDA team
Neuteboom, L.W.; Matsumoto, K.O.; Christopher, D.A.
An extended AE-rich N-terminal trunk in secreted pineapple cystatin enhances inhibition of fruit bromelain and is posttranslationally removed during ripening
Plant Physiol.
151
515-527
2009
Ananas comosus (O23791), Ananas comosus
Manually annotated by BRENDA team
Liang, H.; Li, M.; Shi, M.; Liao, A.; Wu, R.
Study on the stability of fruit bromelain
Adv. Mater. Res.
421
19-22
2012
Ananas comosus
-
Manually annotated by BRENDA team
Ferreira, J.; Bresolin, L.; Silveira, E.; Tambourgi, E.
Purification of bromelain from ananas comosus by PEG/phosphate ATPS
Chem. Eng. Transact.
24
931-936
2011
Ananas comosus
-
Manually annotated by BRENDA team
Yin, L.; Sun, C.; Han, X.; Xu, L.; Xu, Y.; Qi, Y.; Peng, J.
Preparative purification of bromelain (EC 3.4.22.33) from pineapple fruit by high-speed counter-current chromatography using a reverse-micelle solvent system
Food Chem.
129
925-932
2011
Ananas comosus
Manually annotated by BRENDA team
Gautam, S.; Mishra, S.; Dash, V.; Goyal, A.; Rath, G.
Comparative study of extraction, purification and estimation of bromelain from stem and fruit of pineapple plant
Thai J. Pharm. Sci.
34
67-76
2010
Ananas comosus
-
Manually annotated by BRENDA team
Arshad, Z.I.; Amid, A.; Yusof, F.; Jaswir, I.; Ahmad, K.; Loke, S.P.
Bromelain: an overview of industrial application and purification strategies
Appl. Microbiol. Biotechnol.
98
7283-7297
2014
Ananas comosus (O23791), Ananas comosus
Manually annotated by BRENDA team
Corzo, C.; Waliszewski, K.; Welti-Chanes, J.
Pineapple fruit bromelain affinity to different protein substrates
Food Chem.
133
631-635
2012
Ananas comosus (O23791)
Manually annotated by BRENDA team
Devi, Y.; Rupachandra Singh, L.; Kunjeshwori Devi, S.
Pineapple fruit bromelain and its application: A review
Indian J. Agric. Biochem.
25
1-7
2012
Ananas comosus (O23791)
-
Manually annotated by BRENDA team
Mohan, R.; Sivakumar, V.; Rangasamy, T.; Muralidharan, C.
Optimisation of bromelain enzyme extraction from pineapple (Ananas comosus) and application in process industry
Am. J. Biochem. Biotechnol.
12
188-195
2016
Ananas comosus (O23791)
-
Manually annotated by BRENDA team
Misran, E.; Idris, A.; Mat Sarip, S.; Yaakob, H.
Properties of bromelain extract from different parts of the pineapple variety Morris
Biocatal. Agricult. Biotechnol.
18
101095
2019
Ananas comosus
-
Manually annotated by BRENDA team
Ramli, A.N.M.; Manas, N.H.A.; Hamid, A.A.A.; Hamid, H.A.; Illias, R.M.
Comparative structural analysis of fruit and stem bromelain from Ananas comosus
Food Chem.
266
183-191
2018
Ananas comosus (O23791), Ananas comosus
Manually annotated by BRENDA team
Meza-Espinoza, L.; de Los Angeles Vivar-Vera, M.; de Lourdes Garcia-Magana, M.; Sayago-Ayerdi, S.G.; Chacon-Lopez, A.; Becerrea-Verdin, E.M.; Montalvo-Gonzalez, E.
Enzyme activity and partial characterization of proteases obtained from Bromelia karatas fruit and compared with Bromelia pinguin proteases
Food Sci. Biotechnol.
27
509-517
2018
Bromelia pinguin, Bromelia karatas
Manually annotated by BRENDA team
Chakraborty, S.; Rao, P.; Mishra, H.
Modeling the inactivation kinetics of fruit bromelain in pineapple during high-pressure and thermal treatments
Innov. Food Sci. Emerg. Technol.
33
10-18
2016
Ananas comosus (O23791)
-
Manually annotated by BRENDA team
Sao Paulo Barretto Miranda, I.K.; Fontes Suzart Miranda, A.; Souza, F.V.; Vannier-Santos, M.A.; Pirovani, C.P.; Pepe, I.M.; Rodowanski, I.J.; Ferreira, K.T.; Mendes Souza Vaz, L.; de Assis, S.A.
The biochemical characterization, stabilization studies and the antiproliferative effect of bromelain against B16F10 murine melanoma cells
Int. J. Food Sci. Nutr.
68
442-454
2017
Ananas comosus (O23791), Ananas comosus (O23801), Ananas comosus AGB 772 (O23791), Ananas comosus AGB 772 (O23801)
Manually annotated by BRENDA team
Das, S.; Bhattacharyya, D.
Destabilization of human insulin fibrils by peptides of fruit bromelain derived from Ananas comosus (pineapple)
J. Cell. Biochem.
118
4881-4896
2017
Ananas comosus (O23791), Ananas comosus
Manually annotated by BRENDA team
Ghensi, P.; Cucchi, A.; Bonaccorso, A.; Ferroni, L.; Gardin, C.; Mortellaro, C.; Zavan, B.
In vitro effect of bromelain on the regenerative properties of mesenchymal stem cells
J. Craniofac. Surg.
30
1064-1067
2019
Ananas comosus (O24641)
Manually annotated by BRENDA team
Andjaitan, M.; Tutunnugrah, T.; Pamudja, K.; Idris, F.; Tjandra, M.; Wiriantono, T.
Bromelain enzyme from pineapple fruit as an antiviral agent against HIV, hepatitis C and human papiloma virus
J. Eng. Appl. Sci.
13
3125-3130
2018
Ananas comosus (O23791)
-
Manually annotated by BRENDA team
Zhi, N.; Zong, K.; Jia, X.; Wang, L.; Liang, J.
Effect of high pressure processing on fibrinolytic activity of fruit bromelain in vivo
J. Food Process Eng.
42
e13146
2019
Ananas comosus (O23791)
-
Manually annotated by BRENDA team
Kaur, T.; Kaur, A.; Grewal, R.K.
Kinetics studies with fruit bromelain (Ananas comosus) in the presence of cysteine and divalent ions
J. Food Sci. Technol.
52
5954-5960
2015
Ananas comosus (O23791)
Manually annotated by BRENDA team