3.4.22.33: Fruit bromelain
This is an abbreviated version!
For detailed information about Fruit bromelain, go to the full flat file.
Reaction
Hydrolysis of proteins with broad specificity for peptide bonds. Bz-Phe-Val-Arg-/-NHMec is a good synthetic substrate, but there is no action on Z-Arg-Arg-NHMec (c.f. stem bromelain) =
Synonyms
ACMD2_17643, Ananase, Bromelain, bromelain A, bromelain B, Bromelain, juice, Bromelase, Bromelin, EC 3.4.22.4, EC 3.4.22.5, EC 3.4.4.24, Extranase, fastuosain, FBM, Fruit bromelain, Fruit bromelain FA2, Juice bromelain, More, Pinase, Traumanase
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Reference
Reference on EC 3.4.22.33 - Fruit bromelain
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Murachi, T.
Bromelain enzymes
Methods Enzymol.
19
273-284
1970
Ananas comosus
-
Ota, S.; Horie, K.; Hagino, F.; Hashimoto, C.; Date, H.
Fractionation and some properties of the proteolytically active components of bromelains in the stem and the fruit of the pineapple plant
J. Biochem.
71
817-830
1972
Ananas comosus
Ota, S.; Muta, E.; Katahira, Y.; Okamoto, Y.
Reinvestigation of fractionation and some properties of the proteolytically active components of stem and fruit bromelains
J. Biochem.
98
219-228
1985
Ananas comosus
Rowan, A.D.; Brzin, J.; Buttle, D.J.; Barrett, A.J.
Inhibition of cysteine proteinases by a protein inhibitor from potato
FEBS Lett.
269
328-330
1990
Ananas comosus
Suh, H.J.; Lee, H.; Cho, H.Y.; Yang, H.C.
Purification and characterization of bromelain isolated from pineapple
Han'guk Nonghwa Hakhoechi
35
300-307
1992
Ananas comosus
-
Yamada, F.; Takahashi, N.; Murachi, T.
Purification and characterization of a proteinase from pineapple fruit, fruit bromelain FA2
J. Biochem.
79
1223-1234
1976
Ananas comosus
Sasaki, M.; Kato, T.; Iida, S.
Antigenic determinant common to four kinds of thiol proteases of plant origin
J. Biochem.
74
635-637
1973
Ananas comosus
Toro-Goyco, E.; Rodriguez-Costas, I.
Immunochemical studies on pinguinain. A sulfhydryl plant protease
Arch. Biochem. Biophys.
175
359-366
1976
Ananas comosus, Bromelia pinguin
Maurer, H.R.
Bromelain: biochemistry, pharmacology and medical use
Cell. Mol. Life Sci.
58
1234-1245
2001
Ananas comosus
Rowan, A.D.
Fruit bromelain
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
2
1137-1138
2004
Ananas comosus
-
Hale, L.P.; Greer, P.K.; Trinh, C.T.; James, C.L.
Proteinase activity and stability of natural bromelain preparations
Int. Immunopharmacol.
5
783-793
2005
Ananas comosus
Hemavathi, A.B.; Hebbar, H.U.; Raghavarao, K.S.
Reverse micellar extraction of bromelain from Ananas comosus L. Merryl
J. Chem. Technol. Biotechnol.
82
985-992
2007
Ananas comosus (O23791)
-
Cabral, H.; Leopoldino, A.M.; Tajara, E.H.; Greene, L.J.; Faca, V.M.; Mateus, R.P.; Ceron, C.R.; de Souza Judice, W.A.; Julianod, L.; Bonilla-Rodriguez, G.O.
Preliminary functional characterization, cloning and primary sequence of Fastuosain, a cysteine peptidase isolated from fruits of Bromelia fastuosa
Protein Pept. Lett.
13
83-89
2006
Bromelia fastuosa (Q6Q2T4), Bromelia fastuosa
Shukor, M.Y.; Masdor, N.; Baharom, N.A.; Jamal, J.A.; Abdullah, M.P.; Shamaan, N.A.; Syed, M.A.
An inhibitive determination method for heavy metals using bromelain, a cysteine protease
Appl. Biochem. Biotechnol.
144
283-291
2008
Ananas comosus
Neuteboom, L.W.; Matsumoto, K.O.; Christopher, D.A.
An extended AE-rich N-terminal trunk in secreted pineapple cystatin enhances inhibition of fruit bromelain and is posttranslationally removed during ripening
Plant Physiol.
151
515-527
2009
Ananas comosus (O23791), Ananas comosus
Liang, H.; Li, M.; Shi, M.; Liao, A.; Wu, R.
Study on the stability of fruit bromelain
Adv. Mater. Res.
421
19-22
2012
Ananas comosus
-
Ferreira, J.; Bresolin, L.; Silveira, E.; Tambourgi, E.
Purification of bromelain from ananas comosus by PEG/phosphate ATPS
Chem. Eng. Transact.
24
931-936
2011
Ananas comosus
-
Yin, L.; Sun, C.; Han, X.; Xu, L.; Xu, Y.; Qi, Y.; Peng, J.
Preparative purification of bromelain (EC 3.4.22.33) from pineapple fruit by high-speed counter-current chromatography using a reverse-micelle solvent system
Food Chem.
129
925-932
2011
Ananas comosus
Gautam, S.; Mishra, S.; Dash, V.; Goyal, A.; Rath, G.
Comparative study of extraction, purification and estimation of bromelain from stem and fruit of pineapple plant
Thai J. Pharm. Sci.
34
67-76
2010
Ananas comosus
-
Arshad, Z.I.; Amid, A.; Yusof, F.; Jaswir, I.; Ahmad, K.; Loke, S.P.
Bromelain: an overview of industrial application and purification strategies
Appl. Microbiol. Biotechnol.
98
7283-7297
2014
Ananas comosus (O23791), Ananas comosus
Corzo, C.; Waliszewski, K.; Welti-Chanes, J.
Pineapple fruit bromelain affinity to different protein substrates
Food Chem.
133
631-635
2012
Ananas comosus (O23791)
Devi, Y.; Rupachandra Singh, L.; Kunjeshwori Devi, S.
Pineapple fruit bromelain and its application: A review
Indian J. Agric. Biochem.
25
1-7
2012
Ananas comosus (O23791)
-
Mohan, R.; Sivakumar, V.; Rangasamy, T.; Muralidharan, C.
Optimisation of bromelain enzyme extraction from pineapple (Ananas comosus) and application in process industry
Am. J. Biochem. Biotechnol.
12
188-195
2016
Ananas comosus (O23791)
-
Misran, E.; Idris, A.; Mat Sarip, S.; Yaakob, H.
Properties of bromelain extract from different parts of the pineapple variety Morris
Biocatal. Agricult. Biotechnol.
18
101095
2019
Ananas comosus
-
Ramli, A.N.M.; Manas, N.H.A.; Hamid, A.A.A.; Hamid, H.A.; Illias, R.M.
Comparative structural analysis of fruit and stem bromelain from Ananas comosus
Food Chem.
266
183-191
2018
Ananas comosus (O23791), Ananas comosus
Meza-Espinoza, L.; de Los Angeles Vivar-Vera, M.; de Lourdes Garcia-Magana, M.; Sayago-Ayerdi, S.G.; Chacon-Lopez, A.; Becerrea-Verdin, E.M.; Montalvo-Gonzalez, E.
Enzyme activity and partial characterization of proteases obtained from Bromelia karatas fruit and compared with Bromelia pinguin proteases
Food Sci. Biotechnol.
27
509-517
2018
Bromelia pinguin, Bromelia karatas
Chakraborty, S.; Rao, P.; Mishra, H.
Modeling the inactivation kinetics of fruit bromelain in pineapple during high-pressure and thermal treatments
Innov. Food Sci. Emerg. Technol.
33
10-18
2016
Ananas comosus (O23791)
-
Sao Paulo Barretto Miranda, I.K.; Fontes Suzart Miranda, A.; Souza, F.V.; Vannier-Santos, M.A.; Pirovani, C.P.; Pepe, I.M.; Rodowanski, I.J.; Ferreira, K.T.; Mendes Souza Vaz, L.; de Assis, S.A.
The biochemical characterization, stabilization studies and the antiproliferative effect of bromelain against B16F10 murine melanoma cells
Int. J. Food Sci. Nutr.
68
442-454
2017
Ananas comosus (O23791), Ananas comosus (O23801), Ananas comosus AGB 772 (O23791), Ananas comosus AGB 772 (O23801)
Das, S.; Bhattacharyya, D.
Destabilization of human insulin fibrils by peptides of fruit bromelain derived from Ananas comosus (pineapple)
J. Cell. Biochem.
118
4881-4896
2017
Ananas comosus (O23791), Ananas comosus
Ghensi, P.; Cucchi, A.; Bonaccorso, A.; Ferroni, L.; Gardin, C.; Mortellaro, C.; Zavan, B.
In vitro effect of bromelain on the regenerative properties of mesenchymal stem cells
J. Craniofac. Surg.
30
1064-1067
2019
Ananas comosus (O24641)
Andjaitan, M.; Tutunnugrah, T.; Pamudja, K.; Idris, F.; Tjandra, M.; Wiriantono, T.
Bromelain enzyme from pineapple fruit as an antiviral agent against HIV, hepatitis C and human papiloma virus
J. Eng. Appl. Sci.
13
3125-3130
2018
Ananas comosus (O23791)
-
Zhi, N.; Zong, K.; Jia, X.; Wang, L.; Liang, J.
Effect of high pressure processing on fibrinolytic activity of fruit bromelain in vivo
J. Food Process Eng.
42
e13146
2019
Ananas comosus (O23791)
-
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