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3.4.22.31: Ananain

This is an abbreviated version!
For detailed information about Ananain, go to the full flat file.

Word Map on EC 3.4.22.31

Reaction

hydrolysis of proteins with broad specificity for peptide bonds. Best reported small molecule substrate Bz-Phe-Val-Arg-/-NHMec, but broader specificity than fruit bromelain =

Synonyms

bromelain protease F9

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.31 Ananain

Inhibitors

Inhibitors on EC 3.4.22.31 - Ananain

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
chicken cystatin
-
strong
-
cystatin
from chicken
-
E-64
-
high inhibitory efficiency leading to complete inhibition, binding structure and interaction analysis, molecular mechanism, overview. Of the trans-epoxysuccinic acid moiety of E-64, the C2 atom is covalently bound to the active site Cys25 Sgamma, irreversibly inhibiting the catalytic activity of Cys25. Accommodation of E-64 in the substrate binding groove of ananain does not cause any major structural alteration of ananain
L-3-carboxy-2,3-trans-epoxypropionylleucylamido(4-guanidino)butane
-
i.e. E-64