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3.4.22.30: Caricain

This is an abbreviated version!
For detailed information about Caricain, go to the full flat file.

Word Map on EC 3.4.22.30

Reaction

hydrolysis of proteins with broad specificity for peptide bonds, similar to those of papain and chymopapain =

Synonyms

caricain, Chymopapain S, More, Papaya peptidase A, Papaya peptidase II, Papaya proteinase 3, Papaya proteinase A, Papaya proteinase III, Papaya proteinase OMEGA, PPIII, PpOmega, procaricain, Proteinase omega, Proteinase, papaya A, Proteinase, papaya, III

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.30 Caricain

Application

Application on EC 3.4.22.30 - Caricain

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug development
caricain would be suitable for enzyme therapy in gluten intolerance and appears to have synergistic action with porcine intestinal extracts, potential for enzyme therapy in coeliac disease
food industry
the enzyme detoxifies gliadin in wheat dough
nutrition
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at low pH, enzyme undergoes conformational transition leading to instability and rapid degradation by pepsin. To be effective in gut after oral administration, enzyme needs to be protected against acid denaturation and degradation