3.4.22.3: ficain
This is an abbreviated version!
For detailed information about ficain, go to the full flat file.
Word Map on EC 3.4.22.3
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3.4.22.3
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papain
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bromelain
-
proteinases
-
cathepsins
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chymotrypsin
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ficus
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cystatins
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latex
-
alpha-chymotrypsin
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alloantibody
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chymopapain
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phytocystatins
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active-centre
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actinidin
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analysis
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antiglobulin
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medicine
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food industry
-
synthesis
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2,2\'-dipyridyl
-
industry
- 3.4.22.3
- papain
- bromelain
- proteinases
- cathepsins
- chymotrypsin
- ficus
- cystatins
- latex
- alpha-chymotrypsin
-
alloantibody
- chymopapain
-
phytocystatins
-
active-centre
- actinidin
- analysis
-
antiglobulin
- medicine
- food industry
- synthesis
-
2,2\'-dipyridyl
- industry
Reaction
Similar to that of papain =
Synonyms
debricin, EC 3.4.4.12, ficin, ficin A, ficin B, ficin C, ficin D1, ficin D2, ficin E, ficin S, higueroxyl Delabarre
ECTree
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Reference on EC 3.4.22.3 - ficain
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gray, C.J.; Boukouvalas, J.; Szawelski, R.J.; Wharton, C.W.
Benzyloxycarbonylphenylalanylcitrulline p-nitroanilide as a substrate for papain and other plant cysteine proteinases
Biochem. J.
219
325-328
1984
Ficus sp.
Wakamatsu, N.; Kominami, E.; Katunuma, N.
Comparison of properties of thiol proteinase inhibitors from rat serum and liver
J. Biol. Chem.
257
14653-14656
1982
Ficus sp.
Rodis, P.; Hoff, J.E.
Naturally occurring protein crystals in the potato. Inhibitor of papain, chymopapain, and ficin
Plant Physiol.
74
907-911
1984
Ficus sp.
Lynn, K.R.; Clevette-Radford, N.A.
Ficin E, a serine-centred protease from Ficus elastica
Phytochemistry
25
1559-1561
1986
Ficus elastica
-
Minakata, K.; Asano, M.
Acidic cysteine proteinase inhibitor in seminal plasma
Biol. Chem. Hoppe-Seyler
366
15-18
1985
Ficus sp.
Friedenson, B.; Liener, I.E.
Evidence that ficin is a glycoprotein
Biochim. Biophys. Acta
342
209-212
1974
Ficus sp.
Anderson, C.D.; Hall, P.L.
Purification of ficin by affinity chromatography
Anal. Biochem.
60
417-423
1974
Ficus sp.
Hall, P.L.; Anderson, C.D.
Proflavine interactions with papain and ficin. II. Effects of dye binding upon reversible inhibition
Biochemistry
13
2087-2092
1974
Ficus sp.
Hall, P.L.; Anderson, C.D.
Proflavine interactions with papain and ficin. I. Dye binding and its effects upon enzyme inactivation by N-alkylmaleimides
Biochemistry
13
2082-2087
1974
Ficus sp.
Kortt, A.A.; Hinds, J.A.; Zerner, B.
On the specificity and pH dependence of ficin-catalyzed hydrolyses. Some comparisons with bromelain specificity
Biochemistry
13
2029-2037
1974
Ficus sp.
Kortt, A.A.; Hamilton, S.; Webb, E.C.; Zerner, B.
Ficins (EC 3.4.22.3). Purification and characterization of the enzymatic components of the latex of Ficus glabrata
Biochemistry
13
2023-2028
1974
Ficus glabrata
Sugiura, M.; Sasaki, M.
Studies on proteinases from Ficus carica var. Horaishi. V. Purification and properties of a sugar-containing proteinase (ficin S)
Biochim. Biophys. Acta
350
38-47
1974
Ficus carica
Sasaki, M.; Yamamoto, H.; Yamamoto, H.; Iida, S.
Interaction of human serum proteinase inhibitors with proteolytic enzymes of animal, plant, and bacterial origin
J. Biochem.
75
171-177
1974
Ficus sp.
Björk, I.; Ylinenjärvi, K.
Interaction between chicken cystatin and the cysteine proteinases actinidin, chymopapain A, and ficin
Biochemistry
29
1770-1776
1990
Ficus sp.
Hollaway, M.R.; Antonini, E.; Brunori, M.
The pH-dependence of rates of individual steps in ficin catalysis
Eur. J. Biochem.
24
332-341
1971
Ficus sp.
Whitaker, J.R.; Lee, L.S.
Ficin- and papain-catalyzed reactions. Effect of temperature on reactivity of the essential sulfhydryl group of ficin in the presence and absence of competitive inhibitors
Arch. Biochem. Biophys.
148
208-216
1972
Ficus glabrata
Jones, I.K.; Glazer, A.N.
Comparative studies on four sulfhydryl endopeptidases (ficins) of Ficus glabrata latex
J. Biol. Chem.
245
2765-2772
1970
Ficus glabrata
Monter, B.; Herzog, B.; Stehle, P.; Furst, P.
Kinetically controlled synthesis of dipeptides using ficin as biocatalyst
Biotechnol. Appl. Biochem.
14
183-181
1991
Ficus carica
Williams, D.C.; Whitaker, J.R.
Multiple molecular forms of Ficus glabrata ficin. Their separation and relative physical, chemical, and enzymatic properties
Plant Physiol.
44
1574-1583
1969
Ficus glabrata
Englund, P.T.; King, T.P.; Craig, L.C.; Walti, A.
Studies on ficin. I. Its isolation and characterization
Biochemistry
7
163-175
1968
Ficus glabrata
Metrione, R.M.; Johnston, R.B.; Seng, R.
Purification, partial characterization and sequence around a reactive sulfhydryl of ficin
Arch. Biochem. Biophys.
122
137-143
1967
Ficus sp.
Hänsler, M.; Ullmann, G.; Jakubke, H.D.
The Application of papain, ficin and clostripain in kinetically controlled peptide synthesis in frozen aqueous solutions
J. Pept. Sci.
1
283-287
1995
Ficus carica
Liener, I.E.; Friedenson, B.
Ficin
Methods Enzymol.
19
261-273
1970
Ficus anthelmintica, Ficus carica, Ficus glabrata, Ficus sp.
-
Patel, M.; Kayani, I.S.; Mellor, G.W.; Sreedharan, S.; Templeton, W.; Thomas, E.W.; Thomas, M.; Brocklehurst, K.
Variation in the P2-S2 stereochemical selectivity towards the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides among the cysteine proteinases papain, ficin and actinidin
Biochem. J.
281
553-559
1992
Ficus sp.
Mazda, T.; Makino, K.; Yabe, R.; Nakata, K.; Fujisawa, K.; Ohshima, H.
Use of standarized protease enzymes for antibody screening of blood donor samples with the microplate system
Transfus. Med.
5
43-50
1995
Ficus sp.
Mariani, M.; Camagna, M.; Tarditi, L.; Seccamani, E.
A new enzymatic method to obtain high-yield F(ab)2 suitable for clinical use from mouse IgG1
Mol. Immunol.
28
69-77
1991
Ficus sp.
Ruemenapf, T.; Thiel, H.J.
434. Cathepsin T
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
2nd Ed.
1404
2004
Ficus glabrata
-
Sekizaki, H.; Toyota, E.; Fuchise, T.; Zhou, S.; Noguchi, Y.; Horita, K.
Application of several types of substrates to ficin-catalyzed peptide synthesis
Amino Acids
34
149-153
2008
Ficus sp.
Devaraj, K.B.; Kumar, P.R.; Prakash, V.
Purification, characterization, and solvent-induced thermal stabilization of ficin from Ficus carica
J. Agric. Food Chem.
56
11417-11423
2008
Ficus carica
Devaraj, K.B.; Kumar, P.R.; Prakash, V.
Characterization of acid-induced molten globule like state of ficin
Int. J. Biol. Macromol.
45
248-254
2009
Ficus carica
Valdes-Rodriguez, S.; Cedro-Tanda, A.; Aguilar-Hernandez, V.; Cortes-Onofre, E.; Blanco-Labra, A.; Guerrero-Rangel, A.
Recombinant amaranth cystatin (AhCPI) inhibits the growth of phytopathogenic fungi
Plant Physiol. Biochem.
48
469-475
2010
Ficus sp.
Sidek, N.; Halim, A.; Tayyab, S.
Denatured states of ficin induced by urea and guanidine hydrochloride
Turk. J. Biochem.
35
45-49
2010
Ficus sp.
-
Azarkan, M.; Matagne, A.; Wattiez, R.; Bolle, L.; Vandenameele, J.; Baeyens-Volant, D.
Selective and reversible thiol-pegylation, an effective approach for purification and characterization of five fully active ficin (iso)forms from Ficus carica latex
Phytochemistry
72
1718-1731
2011
Ficus carica
Devaraj, K.; Kumar, P.; Prakash, V.
Comparison of activity and conformational changes of ficin during denaturation by urea and guanidine hydrochloride
Process Biochem.
46
458-464
2011
Ficus carica
-
Haesaerts, S.; Rodriguez Buitrago, J.; Loris, R.; Baeyens-Volant, D.; Azarkan, M.
Crystallization and preliminary X-ray analysis of four cysteine proteases from Ficus carica latex
Acta Crystallogr. Sect. F
71
459-465
2015
Ficus carica
Fu, J.; Gao, N.; Yang, Y.; Guan, Z.; He, Y.
Ficin-catalyzed asymmetric aldol reactions of heterocyclic ketones with aldehydes
J. Mol. Catal. B
97
1-4
2013
Ficus carica
-
Raskovic, B.; Lazic, J.; Polovic, N.
Characterisation of general proteolytic, milk clotting and antifungal activity of Ficus carica latex during fruit ripening
J. Sci. Food Agric.
96
576-582
2015
Ficus carica
Zare, H.; Moosavi-Movahedi, A.A.; Salami, M.; Mirzaei, M.; Saboury, A.A.; Sheibani, N.
Purification and autolysis of the ficin isoforms from fig (Ficus carica cv. Sabz) latex
Phytochemistry
87
16-22
2013
Ficus carica
Gagaoua, M.; Boucherba, N.; Bouanane-Darenfed, A.; Ziane, F.; Nait-Rabah, S.; Hafid, K.; Boudechicha, H.
Three-phase partitioning as an efficient method for the purification and recovery of ficin from Mediterranean fig (Ficus carica L.) latex
Sep. Purif. Technol.
132
461-467
2014
Ficus carica
-
Milosevic, J.; Jankovic, B.; Prodanovic, R.; Polovic, N.
Comparative stability of ficin and papain in acidic conditions and the presence of ethanol
Amino Acids
51
829-838
2019
Ficus carica
Homaei, A.; Stevanato, R.; Etemadipour, R.; Hemmati, R.
Purification, catalytic, kinetic and thermodynamic characteristics of a novel ficin from Ficus johannis
Biocatal. Agricult. Biotechnol.
10
360-366
2017
Ficus johannis
-
Zare, H.; Moosavi-Movahedi, A.A.; Salami, M.; Sheibani, N.; Khajeh, K.; Habibi-Rezaei, M.
Autolysis control and structural changes of purified ficin from Iranian fig latex with synthetic inhibitors
Int. J. Biol. Macromol.
84
464-471
2016
Ficus
Baeyens-Volant, D.; Matagne, A.; El Mahyaoui, R.; Wattiez, R.; Azarkan, M.
A novel form of ficin from Ficus carica latex Purification and characterization
Phytochemistry
117
154-167
2015
Ficus carica
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