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3.4.22.29: picornain 2A

This is an abbreviated version!
For detailed information about picornain 2A, go to the full flat file.

Word Map on EC 3.4.22.29

Reaction

selective cleavage of Tyr-/-Gly bond in picornavirus polyprotein =

Synonyms

2A cysteine protease, 2A protease, 2A proteinase, 2Apro, coxsackievirus B3 2A protease, CV-B3 proteinase 2A, CVB3 2A, enterovirus 2A protease, EV-A71 2Apro, EV71-2A, HRV 2A protease, HRV16 2A, HRVC15 2Apro, P2A, picornaviral 2A protein, picornaviral 2A proteinase, picornavirus 2A proteinase, picornavirus endopeptidase 2A, poliovirus 2A protease, poliovirus 2Apro, poliovirus protease 2A, poliovirus protease 2Apro, protease 2A, proteinase 2A, proteinase 2Apro, proteinase, poliovirus, 2A, PV 2Apro, rhinovirus protease 2A, ubiquitin-specific protease 2a, USP2a, Y-G proteinase 2A

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.29 picornain 2A

General Information

General Information on EC 3.4.22.29 - picornain 2A

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
-
regulation of enterovirus 2A protease-associated viral IRES activities by the cell's ERK signaling cascade. The positive regulation of virus replication by the ERK cascade is mediated through effects on both the cis-cleavage of the viral polyprotein by 2Apro and its trans-cleavage of cellular eIF4GI. The ERK cascade positively regulates EV-A71-mediated cleavage of eIF4GI that establishes the cellular conditions which favour vIRES-dependent translation. This ERK-2Apro linked network coordinating vIRES efficiency is also found in other important human enteroviruses
physiological function
additional information