3.4.22.24: cathepsin T
This is an abbreviated version!
For detailed information about cathepsin T, go to the full flat file.
Word Map on EC 3.4.22.24
Reaction
interconversion of the three forms of tyrosine aminotransferase, EC 2.6.1.5 =
ECTree
3.4.22.24 cathepsin TAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.4.22.24 - cathepsin T
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Cbz-Phe-Arg-7-amido-4-methylcoumarin + H2O
Cbz-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Performic acid-oxidized ribonuclease A + H2O
Hydrolyzed performic acid-oxidized ribonuclease A
Tyrosine aminotransferase + H2O
?
-
involved in generation of isozymic forms of tyrosine transferase
-
-
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
Performic acid-oxidized ribonuclease A + H2O
Hydrolyzed performic acid-oxidized ribonuclease A
-
-
-
-
?
Performic acid-oxidized ribonuclease A + H2O
Hydrolyzed performic acid-oxidized ribonuclease A
-
even at 0øC
several fragments
?
tyrosine aminotransferase + H2O
truncated tyrosine aminotransferase + peptide
-
53 kDa substrate monomer, cleavage at the N-terminus of the protein, interconversion of the 3 different forms of the substrate enzyme without alteration of its enzymatic activity related to the substrate's short half-life in the cell
49 kDa product monomer and 4.5 kDa N-terminal peptide
-
?
tyrosine aminotransferase + H2O
truncated tyrosine aminotransferase + peptide
-
53 kDa substrate monomer, cleavage at the N-terminus of the protein, interconversion of the 3 different forms of the substrate enzyme without alteration of its enzymatic activity
49 kDa product monomer and 4.5 kDa N-terminal peptide
-
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
-
-
-
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
dimer of MW 52000 subunits
enzyme form II: dimer of MW 53000 + MW 49000, enzyme form III: dimer of MW 48000
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
enzyme converses native larger subunit to smaller subunit
-
-
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
from rat liver cytosol
enzyme form II: dimer of MW 53000 + MW 49000, enzyme form III: dimer of MW 48000
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
from rat liver cytosol
no release of amino acids, amino acid composition of acidic peptide
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
thereby generating multiple forms of tyrosine aminotransferase
-
-
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
thereby generating multiple forms of tyrosine aminotransferase
enzyme form II: dimer of MW 53000 + MW 49000, enzyme form III: dimer of MW 48000
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
thereby generating multiple forms of tyrosine aminotransferase
no release of amino acids, amino acid composition of acidic peptide
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
thereby generating multiple forms of tyrosine aminotransferase
enzyme form III: dimer of MW 49000
?
Tyrosine aminotransferase form I + H2O
Tyrosine aminotransferase form II and III + acidic peptide of MW 4500 peptide
-
i.e. L-tyrosine:2-oxoglutarate aminotransferase or EC 2.6.1.5
enzyme form II: dimer of MW 53000 + MW 49000, enzyme form III: dimer of MW 48000
?
additional information
?
-
-
no hydrolysis of synthetic low MW substrates for exopeptidases, e.g. Gly-(L)-Phe-beta-naphthylamide, L-Ser-(L)-Tyr-beta-naphthylamide, L-Leu-beta-naphthylamide, L-Arg-beta-naphthylamide, L-leucinamide, hippuryl-L-arginine, hippuryl-L-phenylalanine, N-benzoyl-L-tyrosine ethyl ester
-
-
?
additional information
?
-
-
cytosolic or mitochondrial forms of aspartate aminotransferase
-
-
?
additional information
?
-
-
cytosolic or mitochondrial forms of aspartate aminotransferase
-
-
?
additional information
?
-
-
Nalpha-benzoyl-(DL)-Arg-beta-naphthylamide
-
-
?
additional information
?
-
-
little or no activity at 0øC with glucose 6-phosphate dehydrogenase, native ribonuclease A, native bovine serum albumin, cytochrome c or oxidized insulin B-chain
-
-
?
additional information
?
-
-
little or no activity at 0øC with glucose 6-phosphate dehydrogenase, native ribonuclease A, native bovine serum albumin, cytochrome c or oxidized insulin B-chain
-
-
?
