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3.4.22.2: papain

This is an abbreviated version!
For detailed information about papain, go to the full flat file.

Word Map on EC 3.4.22.2

Reaction

Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1' =

Synonyms

Adolph's Meat Tenderizer, arbuz, CpXCP5, EC 3.4.4.10, enzeco papain, papain, papain-like cysteine protease, papain-like protease, papaine, papaya peptidase I, papaya proteinase 1, Papaya proteinase I, papayotin, PLCP, PLpro, PPI, summetrin, velardon

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.2 papain

Molecular Weight

Molecular Weight on EC 3.4.22.2 - papain

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20700
-
enzyme from commercial chymopapain, equilibrium measurement
23000
-
SDS-PAGE
23406
-
x * 23406, calculation from amino acid sequence
23429
-
x * 23429, calculation from amino acid sequence
23700
-
equilibrium sedimentation
23800
-
enzyme from spray-dried latex, equilibrium measurement
42000
propapain containing respective fusion-tag sequence, determined by SDS-PAGE
additional information
during processing of propapain to papain, 2 intermediates are observed in the range of 30-38 kDa at 20 min incubation at 50°C indicating that processing of propapain to papain occurs in a stepwise manner