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3.4.22.2: papain

This is an abbreviated version!
For detailed information about papain, go to the full flat file.

Word Map on EC 3.4.22.2

Reaction

Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1' =

Synonyms

Adolph's Meat Tenderizer, arbuz, CpXCP5, EC 3.4.4.10, enzeco papain, papain, papain-like cysteine protease, papain-like protease, papaine, papaya peptidase I, papaya proteinase 1, Papaya proteinase I, papayotin, PLCP, PLpro, PPI, summetrin, velardon

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.2 papain

KI Value

KI Value on EC 3.4.22.2 - papain

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.096
acetyl-Phe-Gly-S-nitrosopenicillamine
-
pH 6.2, 25°C
0.0000033
benzyloxycarbonyl-Phe-Ala-glyoxal
-
pH 7.03, 25°C
0.000000036
chagasin
inactivation of papain is very fast, rate constant for inactivation is 1500 mM/s
-
0.0063
CNWAAGYNCGGGS-NH2
-
pH 6.8, 37°C
0.0286
CNWTLGGYKCGGGS-NH2
-
pH 6.8, 37°C
0.0000018
CpPRI
-
pH 7.5, 37°C
-
0.0071
CWEWGGWHCGGSS-OH
-
pH 6.8, 37°C
0.00000001
cystatin SN, cystatin SN variant G12A/G13A, cystatin SN variant P106G/W107G
-
below
-
0.000057
cystatin variant Y56G/T57G/V58G
-
-
-
0.618
D-glucose-2S-nitroso-N-acetyl-penicillamine
-
pH 6.2, 25°C
0.0000019
papain prosegment
recombinant prosegment, pH 7.0, 20°C, inhibition kinetics
-
0.356
S-nitroso-N-acetyl-DL-penicillamine
-
pH 6.2, 25°C
0.449
S-nitrosocaptopril
-
pH 6.2, 25°C
0.305
S-nitrosoglutathione
-
pH 6.2, 25°C
additional information
additional information
-
inhibition constants for various barley cystatin protease inhibitor variants
-