Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.22.15: cathepsin L

This is an abbreviated version!
For detailed information about cathepsin L, go to the full flat file.

Word Map on EC 3.4.22.15

Reaction

similar to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity =

Synonyms

AgCatL, Aldrichina grahami cysteine proteinase, cat L, Cat L-A, Cath L, cath-L, cathepsin L, cathepsin L isoform CRA-b, cathepsin L-A, cathepsin L-A1, cathepsin L-A2, cathepsin L-A3, cathepsin L-B, cathepsin L-like, cathepsin L-like cysteine protease, cathepsin L-like enzyme, cathepsin L-like protease, cathepsin L-like protein, cathepsin L-like proteinase, cathepsin L-like rCPB2.8, cathepsin L1, cathepsin L1H, cathepsin L3, cathepsin-L, cathepsin-L T2V, CathL, CatL, CATL A IV, CATL-1, CATL-2, CatL1G, CatL1H, CatL5, CL1, CL3, CL41.5, CPL, cpl-1, CsCPL, CsCPL-m, CtL, CTSL, CTSL1, CTSL2, Cwp84, FhCL1, FhCL3, Har-CatL, human cathepsin L, major excreted protein, MEP, PDP, progesterone-dependent protein, rhodesain, SMCL1, SoCatL, sperm-histone protease, TsolCL

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.15 cathepsin L

Turnover Number

Turnover Number on EC 3.4.22.15 - cathepsin L

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5.3
2-aminobenzoyl-Ala-Leu-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
3.8
2-aminobenzoyl-Arg-Leu-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
3.5
2-aminobenzoyl-Asn-Leu-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
3.8
2-aminobenzoyl-Gln-Leu-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
0.4
2-aminobenzoyl-Glu-Glu-epsilon-amino-caproic acid-Glu-Leu-Lys-Leu-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
4
2-aminobenzoyl-Glu-Leu-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
1.2
2-aminobenzoyl-Glu-Leu-Lys-Leu-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
0.1
2-aminobenzoyl-Gly-Leu-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
5.9
2-aminobenzoyl-His-Leu-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
2.3
2-aminobenzoyl-Ile-Leu-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
3.2
2-aminobenzoyl-Lys-Arg-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
0.4
2-aminobenzoyl-Lys-Asn-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
0.4
2-aminobenzoyl-Lys-Asp-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
1.7
2-aminobenzoyl-Lys-Gln-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
0.4
2-aminobenzoyl-Lys-Glu-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
0.5
2-aminobenzoyl-Lys-Gly-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
1.3
2-aminobenzoyl-Lys-His-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
2.3
2-aminobenzoyl-Lys-Ile-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
1.1
2-aminobenzoyl-Lys-Leu-Ala-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
3.7
2-aminobenzoyl-Lys-Leu-Arg-Arg-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
6.3
2-aminobenzoyl-Lys-Leu-Arg-Asn-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
5.8
2-aminobenzoyl-Lys-Leu-Arg-Gln-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
4.9
2-aminobenzoyl-Lys-Leu-Arg-Glu-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
3.4
2-aminobenzoyl-Lys-Leu-Arg-Gly-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
7.3
2-aminobenzoyl-Lys-Leu-Arg-His-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
3.9
2-aminobenzoyl-Lys-Leu-Arg-Ile-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
4.1
2-aminobenzoyl-Lys-Leu-Arg-Ser-Ala-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
3.6
2-aminobenzoyl-Lys-Leu-Arg-Ser-Arg-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
2.3
2-aminobenzoyl-Lys-Leu-Arg-Ser-Asn-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
4.2
2-aminobenzoyl-Lys-Leu-Arg-Ser-Gln-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
4.1
2-aminobenzoyl-Lys-Leu-Arg-Ser-Glu-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
4.8
2-aminobenzoyl-Lys-Leu-Arg-Ser-Gly-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
3.7
2-aminobenzoyl-Lys-Leu-Arg-Ser-His-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
2.4
2-aminobenzoyl-Lys-Leu-Arg-Ser-Ile-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
6
2-aminobenzoyl-Lys-Leu-Arg-Ser-Pro-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
4.6
2-aminobenzoyl-Lys-Leu-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
3.2
2-aminobenzoyl-Lys-Leu-Arg-Ser-Val-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
5.5
2-aminobenzoyl-Lys-Leu-Arg-Val-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
1.1
2-aminobenzoyl-Lys-Leu-Asn-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
0.2
2-aminobenzoyl-Lys-Leu-Asp-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
0.9
2-aminobenzoyl-Lys-Leu-Gln-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
2.6
2-aminobenzoyl-Lys-Leu-Glu-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
0.4
2-aminobenzoyl-Lys-Leu-Gly-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
1.3
2-aminobenzoyl-Lys-Leu-His-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
0.4
2-aminobenzoyl-Lys-Leu-Ile-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
3.1
2-aminobenzoyl-Lys-Leu-Lys-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
0.4
2-aminobenzoyl-Lys-Leu-Met-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
0.1
2-aminobenzoyl-Lys-Leu-Pro-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
1.5
2-aminobenzoyl-Lys-Leu-Ser-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
1.3
2-aminobenzoyl-Lys-Leu-Thr-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
0.5
2-aminobenzoyl-Lys-Leu-Val-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
1.9
2-aminobenzoyl-Lys-Lys-epsilon-amino-caproic acid-Glu-Leu-Lys-Leu-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
4
2-aminobenzoyl-Lys-Met-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
13.5
2-aminobenzoyl-Lys-Phe-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
1.2
2-aminobenzoyl-Lys-Pro-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
1.9
2-aminobenzoyl-Lys-Ser-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
0.4
2-aminobenzoyl-Lys-Thr-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
1.9
2-aminobenzoyl-Lys-Trp-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
7.8
2-aminobenzoyl-Lys-Tyr-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
6.4
2-aminobenzoyl-Lys-Val-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
2.1
2-aminobenzoyl-Val-Leu-Arg-Ser-Ser-Lys-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
50 mM Na-acetate, 100 mM NaCl, 2.5 mM EDTA, pH 5.5, 37°C
17.4
Abz-3-biphenyl-L-Ala-Arg-Ala-Ala-Tyr(3-NO2)-NH2
-
in 50 mM Mes buffer (pH 6.0) containing 5 mM dithiothreitol, at 37°C
27
Abz-3-biphenyl-L-Ala-Arg-Ala-Gln-Tyr(3-NO2)-NH2
-
in 50 mM Mes buffer (pH 6.0) containing 5 mM dithiothreitol, at 37°C
5.01
Abz-3-biphenyl-L-Ala-Arg-Ala-Ser-Tyr(3-NO2)-NH2
-
in 50 mM Mes buffer (pH 6.0) containing 5 mM dithiothreitol, at 37°C
0.49
Abz-PR-acetyl-K-QLATKAARKSAK-Dnp
pH and temperature not specified in the publication
0.37
Abz-PRKQLAT-acetyl-K-AARKSAK-Dnp
pH and temperature not specified in the publication
0.51
Abz-PRKQLATKAAR-dimethyl-K-SAK-Dnp
pH and temperature not specified in the publication
0.46
Abz-PRKQLATKAARKSAK-Dnp
pH and temperature not specified in the publication
0.01 - 0.5
benzyloxycarbonyl-Gly-Pro-Arg-7-amido-4-methylcoumarin
1.62 - 27.2
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin
19.8
benzyloxycarbonyl-Lys-p-nitrophenyl ester
-
-
5.53 - 50
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide
1.7 - 46
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
2.64
benzyloxycarbonyl-Pro-Arg-7-amido-4-methylcoumarin
-
wild type enzyme FehCL2, in PBS, pH 7.3, and 100 mM sodium acetate buffer, pH 5.5, each containing 2.5 mM dithiothreitol and 2.5 mM EDTA
0.39 - 1.01
L-Phe-L-Arg-7-amido-4-methylcoumarin
0.89 - 1.07
L-Val-L-Leu-L-Arg-7-amido-4-methylcoumarin
26.6
Leu-Trp-Met-Arg-Phe-Ala
-
-
33.9
leucine enkephalin
-
-
43.2
methionine enkephalin-Arg-Phe
-
-
12.8
N-carbobenzoxy-L-phenylalanine-L-arginine 7-amido-4-methylcoumarin
-
pH 5.5, 37°C
1.52
Pro-Phe-Arg-4-methylcoumarin 7-amide
-
-
2.48
tert-butyloxycarbonyl-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin
-
wild type enzyme FehCL2, in PBS, pH 7.3, and 100 mM sodium acetate buffer, pH 5.5, each containing 2.5 mM dithiothreitol and 2.5 mM EDTA
1.67
tert-butyloxycarbonyl-Val-Leu-Lys-4-methylcoumarin 7-amide
-
-
1.17
tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin
-
wild type enzyme FehCL2, in PBS, pH 7.3, and 100 mM sodium acetate buffer, pH 5.5, each containing 2.5 mM dithiothreitol and 2.5 mM EDTA