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3.4.22.15: cathepsin L

This is an abbreviated version!
For detailed information about cathepsin L, go to the full flat file.

Word Map on EC 3.4.22.15

Reaction

similar to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity =

Synonyms

AgCatL, Aldrichina grahami cysteine proteinase, cat L, Cat L-A, Cath L, cath-L, cathepsin L, cathepsin L isoform CRA-b, cathepsin L-A, cathepsin L-A1, cathepsin L-A2, cathepsin L-A3, cathepsin L-B, cathepsin L-like, cathepsin L-like cysteine protease, cathepsin L-like enzyme, cathepsin L-like protease, cathepsin L-like protein, cathepsin L-like proteinase, cathepsin L-like rCPB2.8, cathepsin L1, cathepsin L1H, cathepsin L3, cathepsin-L, cathepsin-L T2V, CathL, CatL, CATL A IV, CATL-1, CATL-2, CatL1G, CatL1H, CatL5, CL1, CL3, CL41.5, CPL, cpl-1, CsCPL, CsCPL-m, CtL, CTSL, CTSL1, CTSL2, Cwp84, FhCL1, FhCL3, Har-CatL, human cathepsin L, major excreted protein, MEP, PDP, progesterone-dependent protein, rhodesain, SMCL1, SoCatL, sperm-histone protease, TsolCL

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.15 cathepsin L

Molecular Weight

Molecular Weight on EC 3.4.22.15 - cathepsin L

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
14000
18941
-
x * 18941, heavy chain, + x * 5056, light chain, SDS-PAGE
21000
-
1 * 21000 + 1 * 5000, active form
22161
-
x * 22161, calculation from nucleotide sequence
22500
-
x * 22500, ion-spray mass spectrometry
23400
x * 23400, mature isoform CATL-1, calculated from amino acid sequence
23500
-
gel filtration
23668
-
x * 23668, calculation from amino acid composition
23700
x * 23700, mature isoform CATL-2, calculated from amino acid sequence
23790
-
MALDI-TOF mass spectrometry
23800
x * 23800, mature enzyme, calculated from amino acid sequence
23900
-
gel filtration
24000
24300
-
x * 24300, calculation from nucleotide sequence
25000
26000
-
x * 14000 + x * 26000, SDS-PAGE under reducing conditions
27000
27000 - 29000
-
SDS-PAGE, enzyme from pituitary gland
29000
30000
31000
32000
34000
Agama stellio stellio
-
-
34900
-
gel filtration
35000
-
gel filtration
36800
x * 36800, precursor of isoform CATL-1, SDS-PAGE
37000
-
the enzyme exists in a 37000 Da form and a 26000 Da form, gel filtration
37100
x * 37100, precursor of isoform CATL-2, SDS-PAGE
37650
x * 37650, calculated from amino acid sequence
38100
x * 38100, calculated
38300
x * 38300, deglycosylated pro-form, SDS-PAGE
39340
x * 39340, pro-enzyme, calculated from amino acid sequence
40000
405000
-
gel filtration
40700
x * 40700, activated mature enzyme in glycosylated form, SDS-PAGE
41000
-
x * 41300, calculated, including hexahistidine tag, x * 41000, SDS-PAGE
41300
-
x * 41300, calculated, including hexahistidine tag, x * 41000, SDS-PAGE
41500
x * 41500, recombinant fusion protein, SDS-PAGE
42000
-
pro-cathepsin L, SDS-PAGE
45000
x * 45000, SDS-PAGE
47000
47600
x * 47600, glycosylated pro-form, SDS-PAGE
48000
-
SDS-PAGE
50000
5056
-
x * 18941, heavy chain, + x * 5056, light chain, SDS-PAGE
60000
-
SDS-PAGE
61000
62000
recombinant GST-tagged pro-mature enzyme, SDS-PAGE
63000
-
x * 63000, SDS-PAGE
68000
x * 68000, precursor, x * 61000, mature proetin, SDS-PAGE
80000
x * 80000, precursor, x * 47000, mature form, SDS-PAGE