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3.4.22.15: cathepsin L

This is an abbreviated version!
For detailed information about cathepsin L, go to the full flat file.

Word Map on EC 3.4.22.15

Reaction

similar to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity =

Synonyms

AgCatL, Aldrichina grahami cysteine proteinase, cat L, Cat L-A, Cath L, cath-L, cathepsin L, cathepsin L isoform CRA-b, cathepsin L-A, cathepsin L-A1, cathepsin L-A2, cathepsin L-A3, cathepsin L-B, cathepsin L-like, cathepsin L-like cysteine protease, cathepsin L-like enzyme, cathepsin L-like protease, cathepsin L-like protein, cathepsin L-like proteinase, cathepsin L-like rCPB2.8, cathepsin L1, cathepsin L1H, cathepsin L3, cathepsin-L, cathepsin-L T2V, CathL, CatL, CATL A IV, CATL-1, CATL-2, CatL1G, CatL1H, CatL5, CL1, CL3, CL41.5, CPL, cpl-1, CsCPL, CsCPL-m, CtL, CTSL, CTSL1, CTSL2, Cwp84, FhCL1, FhCL3, Har-CatL, human cathepsin L, major excreted protein, MEP, PDP, progesterone-dependent protein, rhodesain, SMCL1, SoCatL, sperm-histone protease, TsolCL

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.15 cathepsin L

KCat KM Value

KCat KM Value on EC 3.4.22.15 - cathepsin L

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
11400
Abz-3-biphenyl-L-Ala-Arg-Ala-Ala-Tyr(3-NO2)-NH2
-
in 50 mM Mes buffer (pH 6.0) containing 5 mM dithiothreitol, at 37°C
26000
Abz-3-biphenyl-L-Ala-Arg-Ala-Gln-Tyr(3-NO2)-NH2
-
in 50 mM Mes buffer (pH 6.0) containing 5 mM dithiothreitol, at 37°C
18600
Abz-3-biphenyl-L-Ala-Arg-Ala-Ser-Tyr(3-NO2)-NH2
-
in 50 mM Mes buffer (pH 6.0) containing 5 mM dithiothreitol, at 37°C
2900
Abz-PR-acetyl-K-QLATKAARKSAK-Dnp
pH and temperature not specified in the publication
6700
Abz-PRKQLAT-acetyl-K-AARKSAK-Dnp
pH and temperature not specified in the publication
5300
Abz-PRKQLATKAAR-dimethyl-K-SAK-Dnp
pH and temperature not specified in the publication
6100
Abz-PRKQLATKAARKSAK-Dnp
pH and temperature not specified in the publication
18.1 - 781
benzoyl-L-Phe-L-Val-L-Arg-7-amido-4-methylcoumarin
38.3 - 5420
D-Val-Leu-Arg-7-amido-4-methylcoumarin
152 - 3148
L-Phe-L-Arg-7-amido-4-methylcoumarin
149 - 211
L-Pro-L-Phe-L-Arg-7-amido-4-methylcoumarin
71.6 - 155.3
L-Val-L-Leu-L-Arg-7-amido-4-methylcoumarin
16.6 - 119
tert-butyloxycarbonyl-L-Ala-Gly-L-Pro-L-Arg-7-amido-4-methylcoumarin
10.1 - 75.2
tert-butyloxycarbonyl-L-Asp-L-Pro-L-Arg-7-amido-4-methylcoumarin
6.75 - 7220
tert-butyloxycarbonyl-L-Val-L-Leu-L-Lys-7-amido-4-methylcoumarin
5.01 - 52.7
tert-butyloxycarbonyl-L-Val-L-Pro-L-Arg-7-amido-4-methylcoumarin
24.4 - 84.3
tosyl-Gly-L-Pro-L-Arg-7-amido-4-methylcoumarin