3.4.21.B59: granzyme H

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For detailed information about granzyme H, go to the full flat file.

Word Map on EC 3.4.21.B59

3.4.21.B59

killer

perforin

ctl

chymotrypsin-like

chymase

diagnostics

Reaction

cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites =

Synonyms

Granzyme H, GrH

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.B59 granzyme H

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Results	in table
1	AA Sequence
1	Application
1	Cloned(Commentary)
18	Disease/ Diagnostics
2	General Information
2	Localization
1	Metals/Ions
1	Natural Substrates/ Products (Substrates)
2	Organism
1	pH Optimum
1	Posttranslational Modification
1	Protein Variants
1	Purification (Commentary)
2	Reaction
2	Reference
6	Source Tissue
3	Substrates and Products (Substrate)
2	Synonyms
1	Temperature Optimum [°C]

General Information

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General Information on EC 3.4.21.B59 - granzyme H

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physiological function

Homo sapiens

P20718

the enzyme induces cell death primarily via a Bcl-2-sensitive mitochondrial cell death pathway that does not require direct Bid activation, overview. Neither the apoptosome nor caspase-3 is essential to the induction of GrH-mediated cell death. The enzyme might have pro-apoptotic activity that might be distinct from that of granzyme B and FasL, which can be relevant when Fas/FasL or granzyme B activity or death pathways are impaired. Direct processing of DFF45 by the enzyme may be leading to DNA damage. The enzyme inhibits caspase-3 activation

732517

additional information

2 entries