3.4.21.B59: granzyme H

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For detailed information about granzyme H, go to the full flat file.

Reaction

cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites =

Synonyms

Granzyme H, GrH

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B59 granzyme H

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Results	in table
1	AA Sequence
1	Application
1	Cloned(Commentary)
18	Disease/ Diagnostics
2	General Information
2	Localization
1	Metals/Ions
1	Natural Substrates/ Products (Substrates)
2	Organism
1	pH Optimum
1	Posttranslational Modification
1	Protein Variants
1	Purification (Commentary)
2	Reaction
2	Reference
6	Source Tissue
3	Substrates and Products (Substrate)
2	Synonyms
1	Temperature Optimum [°C]

Disease

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Disease on EC 3.4.21.B59 - granzyme H

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Breast Neoplasms

Granzyme h serum levels variations with both reproductive hormone receptors, and related hormone receptors in breast cancer patients.

25250148

Breast Neoplasms

To study the significance of apoptotic enzyme granzyme H in breast cancer patients.

19024195

Hepatitis B

Granzyme H of cytotoxic lymphocytes is required for clearance of the hepatitis B virus through cleavage of the hepatitis B virus X protein.

22156339

Lymphoma

Discordant regulation of granzyme H and granzyme B expression in human lymphocytes.

15069086

Lymphoma, T-Cell, Peripheral

Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal type.

19965620

Neoplasms

Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage.

17765974

Neoplasms

Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif.

22156497

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