3.4.21.B57: pernisine

This is an abbreviated version!
For detailed information about pernisine, go to the full flat file.

the enzyme can digest the pathological prion protein isoform (PrPSc) from different species, e.g. human, bovine, deer and mouse =

pernisine, subtilase, Tk-SP, Tk-subtilisin, TKS

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Results	in table
4	Activating Compound
2	AA Sequence
4	Application
11	Cloned(Commentary)
7	Crystallization (Commentary)
1	Expression
3	General Information
13	General Stability
28	Inhibitors
1	Ki Value [mM]
2	KM Value [mM]
5	Localization
10	Metals/Ions
14	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
13	Organic Solvent Stability
38	Organism
10	pH Optimum
4	pH Range
13	Posttranslational Modification
16	Protein Variants
9	Purification (Commentary)
1	Reaction
22	Reference
2	Specific Activity [micromol/min/mg]
36	Substrates and Products (Substrate)
12	Subunits
19	Synonyms
11	Temperature Optimum [°C]
4	Temperature Range [°C]
23	Temperature Stability [°C]
2	Turnover Number [1/s]

Natural Substrates Products on EC 3.4.21.B57 - pernisine

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pro-Tk-subtilisin + H2O

Tk-subtilisin + propeptide

autoactivation

proform pernisine + H2O

mature pernisine + signal sequence-N-terminal pro-region

the enzyme performs autoproteolytical cleavage of its N-terminal pro-region for activation

additional information