3.4.21.B48: kumamolysin
This is an abbreviated version!
For detailed information about kumamolysin, go to the full flat file.
Word Map on EC 3.4.21.B48
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3.4.21.B48
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peptidase
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pepstatin-insensitive
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subtilisin
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hole
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oxyanion
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proteinases
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collagenase
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pepstatin
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merops
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diazoacetyl-dl-norleucine
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sedolisins
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celiac
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subtilisin-like
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acidophilic
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xanthomonas
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leu15-tyr16
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gluten
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alicyclobacillus
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biotechnology
- 3.4.21.B48
- peptidase
-
pepstatin-insensitive
- subtilisin
-
hole
-
oxyanion
- proteinases
- collagenase
- pepstatin
- merops
- diazoacetyl-dl-norleucine
- sedolisins
- celiac
-
subtilisin-like
-
acidophilic
- xanthomonas
-
leu15-tyr16
- gluten
-
alicyclobacillus
- biotechnology
Reaction
specifically hydrolyzes Leu15-Tyr16 peptide bond in oxidized insulin B chain, additional cleavage at Phe25-Tyr26 at a considerably lower rate. Good cleavage of the Phe-I-(p-nitrophenylalanine) bond in synthetic peptides. The enzyme preferentially hydrolyzes peptides having an Ala or Pro residue at P2 position and prefers such charged amino acid residues as Glu or Arg at the P2' position. No cleavage: Asp-Pro-Ala-Lys-Phe-(p-nitrophenylalanine)-Arg-Leu =
Synonyms
J-4 serine-carboxyl proteinase, KSCP, kumamolisin, kumamolisin serine-carboxyl proteinase, kumamolisin-ac, kumamolisin-AS, kumamolisin-like proteae, kumamolysin, More, SCPA
ECTree
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Subunits
Subunits on EC 3.4.21.B48 - kumamolysin
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monomer
additional information
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x * 38000, active recombinant enzyme, SDS-PAGE, x * 19000, recombinant isolated propeptide, SDS-PAGE, x * 57000, inactive recombinant precursor enzyme, SDS-PAGE
?
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x * 38000, active recombinant enzyme, SDS-PAGE, x * 19000, recombinant isolated propeptide, SDS-PAGE, x * 57000, inactive recombinant precursor enzyme, SDS-PAGE
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?
Bacillus novosp.
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x * 41000, native wild-type enzyme, x * 43000, active recombinant wild-type enzyme, SDS-PAGE, x * 45000, inactive, processed recombinant wild-type enzyme, SDS-PAGE, x * 64000, inactive recombinant precursor enzyme, SDS-PAGE
?
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x * 41000, native wild-type enzyme, x * 43000, active recombinant wild-type enzyme, SDS-PAGE, x * 45000, inactive, processed recombinant wild-type enzyme, SDS-PAGE, x * 64000, inactive recombinant precursor enzyme, SDS-PAGE
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?
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x * 41000, native wild-type enzyme, x * 43000, active recombinant wild-type enzyme, SDS-PAGE, x * 45000, inactive, processed recombinant wild-type enzyme, SDS-PAGE, x * 64000, inactive recombinant precursor enzyme, SDS-PAGE
?
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x * 41000, native wild-type enzyme, x * 43000, active recombinant wild-type enzyme, SDS-PAGE, x * 45000, inactive, processed recombinant wild-type enzyme, SDS-PAGE, x * 64000, inactive recombinant precursor enzyme, SDS-PAGE
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the enzyme consists of an N-terminal prepropeptide and the mature enzyme part
additional information
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the enzyme consists of an N-terminal prepropeptide and the mature enzyme part
-
additional information
Bacillus novosp.
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the enzyme consists of an N-terminal prepropeptide and the mature enzyme part
additional information
-
the enzyme consists of an N-terminal prepropeptide and the mature enzyme part
-
additional information
-
the enzyme consists of an N-terminal prepropeptide and the mature enzyme part
additional information
-
the enzyme consists of an N-terminal prepropeptide and the mature enzyme part
-