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3.4.21.B45: kallikrein 14

This is an abbreviated version!
For detailed information about kallikrein 14, go to the full flat file.

Word Map on EC 3.4.21.B45

Reaction

proteolytic cleavage of polypeptides =

Synonyms

hK 14, hK14, kallikrein 14, kallikrein-related peptidase 14, KLK14, S01.029, SCTE

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B45 kallikrein 14

Reference

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Reference on EC 3.4.21.B45 - kallikrein 14

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (Q9P0G3)
Manually annotated by BRENDA team
Hooper, J.D.; Bui, L.T.; Rae, F.K.; Harvey, T.J.; Myers, S.A; Ashworth, L.K.; Clements, J.A.
Identification and characterization of KLK14, novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle
Genomics
73
117-122
2001
Homo sapiens (Q9P0G3), Homo sapiens
Manually annotated by BRENDA team
Felber, L.M.; Borgono, C.A.; Cloutier, S.M.; Kuendig, C.; Kishi, T.; Ribeiro Chagas, J.; Jichlinski, P.; Gygi, C.M.; Leisinger, H.J.; Diamandis, E.P.; Deperthes, D.
Enzymatic profiling of human kallikrein 14 using phage-display substrate technology
Biol. Chem.
386
291-298
2005
Homo sapiens
Manually annotated by BRENDA team
Fritzsche, F.; Gansukh, T.; Borgono, C.A.; Burkhardt, M.; Pahl, S.; Mayordomo, E.; Winzer, K.J.; Weichert, W.; Denkert, C.; Jung, K.; Stephan, C.; Dietel, M.; Diamandis, E.P.; Dahl, E.; Kristiansen, G.
Expression of human Kallikrein 14 (KLK14) in breast cancer is associated with higher tumour grades and positive nodal status
Br. J. Cancer
94
540-547
2006
Homo sapiens
Manually annotated by BRENDA team
Felber, L.M.; Kuendig, C.; Borgono, C.A.; Chagas, J.R.; Tasinato, A.; Jichlinski, P.; Gygi, C.M.; Leisinger, H.J.; Diamandis, E.P.; Deperthes, D.; Cloutier, S.M.
Mutant recombinant serpins as highly specific inhibitors of human kallikrein 14
FEBS J.
273
2505-2514
2006
Homo sapiens
Manually annotated by BRENDA team
Stefansson, K.; Brattsand, M.; Ny, A.; Glas, B.; Egelrud, T.
Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum
Biol. Chem.
387
761-768
2006
Homo sapiens (Q9P0G3), Homo sapiens
Manually annotated by BRENDA team
Emami, N.; Diamandis, E.P.
Human kallikrein-related peptidase 14 (KLK14) is a new activator component of the KLK proteolytic cascade. Possible function in seminal plasma and skin
J. Biol. Chem.
283
3031-3041
2008
Homo sapiens (Q9P0G3), Homo sapiens
Manually annotated by BRENDA team
Deraison, C.; Bonnart, C.; Lopez, F.; Besson, C.; Robinson, R.; Jayakumar, A.; Wagberg, F.; Brattsand, M.; Hachem, J.P.; Leonardsson, G.; Hovnanian, A.
LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction
Mol. Biol. Cell
18
3607-3619
2007
Homo sapiens
Manually annotated by BRENDA team
Fernando, S.C.; Buck, J.S.; Ashworth, M.D.; Ross, J.W.; Geisert, R.D.; DeSilva, U.
Porcine endometrial and conceptus tissue kallikrein 1, 4, 11, and 14 gene expression
Reproduction
132
939-947
2006
Sus scrofa
Manually annotated by BRENDA team
Planque, C.; Blechet, C.; Ayadi-Kaddour, A.; Heuze-Vourch, N.; Dumont, P.; Guyetant, S.; Diamandis, E.P.; El Mezni, F.; Courty, Y.
Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung
Biol. Chem.
389
781-786
2008
Homo sapiens (Q9P0G3), Homo sapiens
Manually annotated by BRENDA team
Emami, N.; Deperthes, D.; Malm, J.; Diamandis, E.P.
Major role of human KLK14 in seminal clot liquefaction
J. Biol. Chem.
283
19561-19569
2008
Homo sapiens (Q9P0G3), Homo sapiens
Manually annotated by BRENDA team
Rabien, A.; Fritzsche, F.; Jung, M.; Diamandis, E.P.; Loening, S.A.; Dietel, M.; Jung, K.; Stephan, C.; Kristiansen, G.
High expression of KLK14 in prostatic adenocarcinoma is associated with elevated risk of prostate-specific antigen relapse
Tumour Biol.
29
1-8
2008
Homo sapiens
Manually annotated by BRENDA team
Emami, N.; Scorilas, A.; Soosaipillai, A.; Earle, T.; Mullen, B.; Diamandis, E.P.
Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility
Biol. Chem.
390
921-929
2009
Homo sapiens
Manually annotated by BRENDA team
Angelopoulou, K.; Prassas, I.; Yousef, G.M.
The canine kallikrein-related peptidase 14: structural characterization, alternative splicing and differential expression in mammary cancer
Gene
446
68-74
2009
Canis lupus familiaris (C7T1J3), Canis lupus familiaris
Manually annotated by BRENDA team
Hashem, N.N.; Mara, T.W.; Mohamed, M.; Zhang, I.; Fung, K.; Kwan, K.F.; Daley, T.D.; Diamandis, E.P.; Darling, M.R.
Human kallikrein 14 (KLK14) expression in salivary gland tumors
Int. J. Biol. Markers
25
32-37
2010
Homo sapiens
Manually annotated by BRENDA team
Meyer-Hoffert, U.; Wu, Z.; Kantyka, T.; Fischer, J.; Latendorf, T.; Hansmann, B.; Bartels, J.; He, Y.; Glaeser, R.; Schroeder, J.M.
Isolation of Spink6 in human skin: a selective inhibitor of kallikrein-related peptidases
J. Biol. Chem.
285
32174-32181
2010
Homo sapiens
Manually annotated by BRENDA team
Gratio, V.; Loriot, C.; Virca, G.D.; Oikonomopoulou, K.; Walker, F.; Diamandis, E.P.; Hollenberg, M.D.; Darmoul, D.
Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells
Am. J. Pathol.
179
2625-2636
2011
Homo sapiens
Manually annotated by BRENDA team
de Veer, S.J.; Swedberg, J.E.; Parker, E.A.; Harris, J.M.
Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14
Biol. Chem.
393
331-341
2012
Homo sapiens (Q9P0G3)
Manually annotated by BRENDA team
Ramachandran, R.; Eissa, A.; Mihara, K.; Oikonomopoulou, K.; Saifeddine, M.; Renaux, B.; Diamandis, E.; Hollenberg, M.D.
Proteinase-activated receptors (PARs): differential signalling by kallikrein-related peptidases KLK8 and KLK14
Biol. Chem.
393
421-427
2012
Homo sapiens (Q9P0G3), Homo sapiens
Manually annotated by BRENDA team
Reid, J.C.; Bennett, N.C.; Stephens, C.R.; Carroll, M.L.; Magdolen, V.; Clements, J.A.; Hooper, J.D.
In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B
Biol. Chem.
397
1299-1305
2016
Homo sapiens (Q9P0G3)
Manually annotated by BRENDA team
Ulbricht, D.; Tindall, C.A.; Oertwig, K.; Hanke, S.; Straeter, N.; Heiker, J.T.
Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin
Biol. Chem.
399
1079-1084
2018
Homo sapiens (Q9P0G3)
Manually annotated by BRENDA team
Kontos, C.K.; Adamopoulos, P.G.; Papageorgiou, S.G.; Pappa, V.; Scorilas, A.
mRNA overexpression of kallikrein-related peptidase 14 (KLK14) is an independent predictor of poor overall survival in chronic lymphocytic leukemia patients
Clin. Chem. Lab. Med.
54
315-324
2016
Homo sapiens (Q9P0G3), Homo sapiens
Manually annotated by BRENDA team