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3.4.21.B43: kallikrein 12

This is an abbreviated version!
For detailed information about kallikrein 12, go to the full flat file.

Word Map on EC 3.4.21.B43

Reaction

proteolytic cleavage of polypeptides =

Synonyms

hK12, K12, kallikrein 12, kallikrein-related peptidase 12, KLK12, S01.020

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B43 kallikrein 12

Disease

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Disease on EC 3.4.21.B43 - kallikrein 12

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Breast Neoplasms
Enzymatic properties of human kallikrein-related peptidase 12 (KLK12).
Human kallikrein-related peptidase 12 (KLK12) splice variants discriminate benign from cancerous breast tumors.
Human kallikrein-related peptidase 12 (KLK12) splice variants expression in breast cancer and their clinical impact.
KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer.
Carcinogenesis
Human kallikrein-related peptidase 12: antibody generation and immunohistochemical localization in prostatic tissues.
Colorectal Neoplasms
Knockdown of KLK12 inhibits viability and induces apoptosis in human colorectal cancer HT-29 cell line.
Silencing KLK12 expression via RGDfC-decorated selenium nanoparticles for the treatment of colorectal cancer in vitro and in vivo.
Dermatitis, Atopic
Association of DOCK8, IL17RA, and KLK12 Polymorphisms with Atopic Dermatitis in Koreans.
Corrigendum: Association of DOCK8, IL17RA, and KLK12 Polymorphisms with Atopic Dermatitis in Koreans.
Dry Eye Syndromes
Elevated Immunoglobulin to Tissue KLK11 in Patients With Sjögren Syndrome.
Hypertension
Transcriptome reveals the overexpression of a kallikrein gene cluster (KLK1/3/7/8/12) in the Tibetans with high altitude-associated polycythemia.
Infections
Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis.
Influenza, Human
Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12.
Lung Neoplasms
CASC15 contributes to proliferation and invasion through regulating miR-766-5p/ KLK12 axis in lung cancer.
Neoplasms
Angiogenesis stimulated by human kallikrein-related peptidase 12 acting via a platelet-derived growth factor B-dependent paracrine pathway.
CASC15 contributes to proliferation and invasion through regulating miR-766-5p/ KLK12 axis in lung cancer.
Common variation in Kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness.
Enzymatic properties of human kallikrein-related peptidase 12 (KLK12).
Human kallikrein-related peptidase 12 (KLK12) splice variants discriminate benign from cancerous breast tumors.
Novel splice variants of the human kallikrein-related peptidases 11 (KLK11) and 12 (KLK12), unraveled by next-generation sequencing technology.
Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA expression in triple-negative breast cancer patients.
Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity.
Tissue factor pathway inhibitor 2 is a potent kallikrein-related protease 12 inhibitor.
Obesity
Transcriptome reveals the overexpression of a kallikrein gene cluster (KLK1/3/7/8/12) in the Tibetans with high altitude-associated polycythemia.
Polycythemia
Transcriptome reveals the overexpression of a kallikrein gene cluster (KLK1/3/7/8/12) in the Tibetans with high altitude-associated polycythemia.
Prostatic Neoplasms
Common variation in Kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness.
Human kallikrein-related peptidase 12: antibody generation and immunohistochemical localization in prostatic tissues.
KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer.
Stomach Neoplasms
Clinical significance of human kallikrein 12 gene expression in gastric cancer.
Kallikrein 12 downregulation reduces AGS gastric cancer cell proliferation and migration.
Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity.
Triple Negative Breast Neoplasms
Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA expression in triple-negative breast cancer patients.